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Family Members' Reward-Based Activation in Response to an AUD Loved-One.

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Title: Family Members' Reward-Based Activation in Response to an AUD Loved-One.
Authors: Shumway, Sterling T., Bradshaw, Spencer D., Zielinski, Mazie, Kimball, Thomas G., Fisher, Jacob T.
Source: Contemporary Family Therapy: An International Journal. Mar2025, Vol. 47 Issue 1, p102-116. 15p.
Subjects: Psychology of alcoholism, Families & psychology, Brain physiology, Hippocampus physiology, Codependency, Family relations, Magnetic resonance imaging, Reward (Psychology), Psychological stress, Convalescence, Psychology of caregivers, Diagnosis of brain abnormalities, Comparative studies
Abstract: Family members of a loved-one with an alcohol use disorder (AUD) experience much stress and other adverse impacts, especially those that are frontline caregivers and therefore most proximal to AUD. Previous research has shown such family members experience altered functioning of the prefrontal cortex in response to images of their loved-one, and these responses have similarities to brain responses to alcohol cues for a person with AUD. The current study aimed to expand this research by examining whole-brain functional activation of family members' brains. Functional magnetic resonance imaging (fMRI) was used to measure activation responses of 10 family members with a loved-one with diagnosed AUD, as well as that of 10 control group participants, during an event-related research paradigm. Results from Generalized Linear Modeling (GLM) indicated significant activation in the left hippocampus and left amygdala for family members of an AUD loved-one, and this activation was significantly greater than that of a control group. These two subcortical regions play a role in the reward network and their activation found in this study may be associated with a reward-based "approach" response – drawing further parallels between the functioning of the impacted family member's brain and that of the brain of someone with AUD. This understanding influences how clinicians might provide services to family members of those with AUD. [ABSTRACT FROM AUTHOR]
Copyright of Contemporary Family Therapy: An International Journal is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Family Members' Reward-Based Activation in Response to an AUD Loved-One.
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  Data: <searchLink fieldCode="JN" term="%22Contemporary+Family+Therapy%3A+An+International+Journal%22">Contemporary Family Therapy: An International Journal</searchLink>. Mar2025, Vol. 47 Issue 1, p102-116. 15p.
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  Data: Family members of a loved-one with an alcohol use disorder (AUD) experience much stress and other adverse impacts, especially those that are frontline caregivers and therefore most proximal to AUD. Previous research has shown such family members experience altered functioning of the prefrontal cortex in response to images of their loved-one, and these responses have similarities to brain responses to alcohol cues for a person with AUD. The current study aimed to expand this research by examining whole-brain functional activation of family members' brains. Functional magnetic resonance imaging (fMRI) was used to measure activation responses of 10 family members with a loved-one with diagnosed AUD, as well as that of 10 control group participants, during an event-related research paradigm. Results from Generalized Linear Modeling (GLM) indicated significant activation in the left hippocampus and left amygdala for family members of an AUD loved-one, and this activation was significantly greater than that of a control group. These two subcortical regions play a role in the reward network and their activation found in this study may be associated with a reward-based "approach" response – drawing further parallels between the functioning of the impacted family member's brain and that of the brain of someone with AUD. This understanding influences how clinicians might provide services to family members of those with AUD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Contemporary Family Therapy: An International Journal is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10591-024-09712-0
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      – SubjectFull: Psychology of alcoholism
        Type: general
      – SubjectFull: Families & psychology
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      – SubjectFull: Brain physiology
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      – SubjectFull: Hippocampus physiology
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      – SubjectFull: Codependency
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      – SubjectFull: Family relations
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      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Reward (Psychology)
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      – SubjectFull: Convalescence
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      – SubjectFull: Comparative studies
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              Text: Mar2025
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