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Facets of mindfulness are associated with inflammation biomarkers in a sample of sexual minority men with HIV.

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Title: Facets of mindfulness are associated with inflammation biomarkers in a sample of sexual minority men with HIV.
Authors: Foley, Jacklyn, Batchelder, Abigail W., Bernier, Lauren, Glynn, Tiffany, Moskowitz, Judith, Carrico, Adam
Source: Psychology, Health & Medicine. Feb2025, Vol. 30 Issue 2, p368-383. 16p.
Subjects: Inflammation prevention, HIV prevention, Mathematical variables, Research funding, Secondary analysis, Methamphetamine, Viral load, Mindfulness, Questionnaires, CD4 lymphocyte count, Psychology of men, Treatment effectiveness, Descriptive statistics, Psychology of HIV-positive persons, Research, Sexual minorities, Cytokines, Biomarkers, Interleukins, Tumor necrosis factors, Regression analysis
Abstract: Sexual minority men (SMM) are disproportionately impacted by HIV and thus, HIV related-health complications. HIV has been linked to earlier onset of multi-morbid chronic diseases and declines in physical and cognitive functioning attributable to chronic HIV immune activation and resulting inflammation. Inflammation has been targeted with mindfulness-based interventions (MBIs); however, hypothesized negative associations between mindfulness and inflammation need to be confirmed in SMM with HIV. This is a secondary data analysis of baseline data from a randomized clinical trial (RCT) of SMM living with HIV with biologically confirmed recent methamphetamine use (ARTEMIS). Mindfulness was assessed with the Five Factor Mindfulness Questionnaire (FFMQ). Inflammation was assessed via cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Separate adjusted (for age, viral load, CD4 count, and methamphetamine use) regression models evaluated associations between four facets of mindfulness (description, awareness, non-judgement, and non-reactivity) with IL-6 and TNF-α. The average age of the participants was 43.86 (SD = 8.95). Both description (b =.54, se =.24) and awareness (b =.50, se=.23) were positively associated with IL-6. All other associations between mindfulness and inflammation were non-significant in adjusted models. There was also some evidence to suggest that engagement in care moderated associations between description and non-reactivity with IL-6 (ΔR2 =.03, F = 3.64), such that description and non-reactivity were each positively associated with inflammation among those who attended <100% of primary care appointments (b = 1.04, se=.34 and b = 1.23, se=.39, respectively), but was not associated with inflammation among those who attended 100% of appointments (b =.16, se=.32 and b=-.17, se=.40, respectively). There was also a significant interaction between 12-step program attendance and awareness with IL-6 (ΔR2=.03, F = 4.26), such that awareness was positively associated with inflammation among those who attended 12-step programming (b = 1.25, se =.41), but not associated with inflammation among those who did not (b =.22, se =.28). Further research is needed to understand how and under what circumstances mindfulness is associated with pro- versus anti-inflammatory processes.Trial Registration: NCT01926184. [ABSTRACT FROM AUTHOR]
Copyright of Psychology, Health & Medicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Facets of mindfulness are associated with inflammation biomarkers in a sample of sexual minority men with HIV.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Sexual minority men (SMM) are disproportionately impacted by HIV and thus, HIV related-health complications. HIV has been linked to earlier onset of multi-morbid chronic diseases and declines in physical and cognitive functioning attributable to chronic HIV immune activation and resulting inflammation. Inflammation has been targeted with mindfulness-based interventions (MBIs); however, hypothesized negative associations between mindfulness and inflammation need to be confirmed in SMM with HIV. This is a secondary data analysis of baseline data from a randomized clinical trial (RCT) of SMM living with HIV with biologically confirmed recent methamphetamine use (ARTEMIS). Mindfulness was assessed with the Five Factor Mindfulness Questionnaire (FFMQ). Inflammation was assessed via cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Separate adjusted (for age, viral load, CD4 count, and methamphetamine use) regression models evaluated associations between four facets of mindfulness (description, awareness, non-judgement, and non-reactivity) with IL-6 and TNF-α. The average age of the participants was 43.86 (SD = 8.95). Both description (b =.54, se =.24) and awareness (b =.50, se=.23) were positively associated with IL-6. All other associations between mindfulness and inflammation were non-significant in adjusted models. There was also some evidence to suggest that engagement in care moderated associations between description and non-reactivity with IL-6 (ΔR2 =.03, F = 3.64), such that description and non-reactivity were each positively associated with inflammation among those who attended &lt;100% of primary care appointments (b = 1.04, se=.34 and b = 1.23, se=.39, respectively), but was not associated with inflammation among those who attended 100% of appointments (b =.16, se=.32 and b=-.17, se=.40, respectively). There was also a significant interaction between 12-step program attendance and awareness with IL-6 (ΔR2=.03, F = 4.26), such that awareness was positively associated with inflammation among those who attended 12-step programming (b = 1.25, se =.41), but not associated with inflammation among those who did not (b =.22, se =.28). Further research is needed to understand how and under what circumstances mindfulness is associated with pro- versus anti-inflammatory processes.Trial Registration: NCT01926184. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Psychology, Health &amp; Medicine is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/13548506.2024.2407445
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 16
        StartPage: 368
    Subjects:
      – SubjectFull: Inflammation prevention
        Type: general
      – SubjectFull: HIV prevention
        Type: general
      – SubjectFull: Mathematical variables
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Secondary analysis
        Type: general
      – SubjectFull: Methamphetamine
        Type: general
      – SubjectFull: Viral load
        Type: general
      – SubjectFull: Mindfulness
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: CD4 lymphocyte count
        Type: general
      – SubjectFull: Psychology of men
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Psychology of HIV-positive persons
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Sexual minorities
        Type: general
      – SubjectFull: Cytokines
        Type: general
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Interleukins
        Type: general
      – SubjectFull: Tumor necrosis factors
        Type: general
      – SubjectFull: Regression analysis
        Type: general
    Titles:
      – TitleFull: Facets of mindfulness are associated with inflammation biomarkers in a sample of sexual minority men with HIV.
        Type: main
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            NameFull: Foley, Jacklyn
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            NameFull: Glynn, Tiffany
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            NameFull: Moskowitz, Judith
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            – D: 01
              M: 02
              Text: Feb2025
              Type: published
              Y: 2025
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