Neurocircuitry in alcoholism: a substrate of disruption and repair.
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| Title: | Neurocircuitry in alcoholism: a substrate of disruption and repair. |
|---|---|
| Authors: | Sullivan, Edith V., Pfefferbaum, Adolf |
| Source: | Psychopharmacology. Aug2005, Vol. 180 Issue 4, p583-594. 12p. 2 Black and White Photographs, 1 Diagram. |
| Subjects: | Alcoholism, Brain, Ataxia, Neural circuitry, Magnetic resonance imaging |
| Abstract: | The chronic, excessive consumption of alcohol results in significant modification of selective neural systems of the brain structure, physiology, and function. Quantitative MR structural imaging, diffusion tensor imaging (DTI), and functional MRI (fMRI), together with neuropsychological challenges, have enabled rigorous in vivo characterization of the results of alcoholism on the brain in the human condition. Neuroimaging has also enabled longitudinal study for the examination of alcoholism’s dynamic course through periods of drinking and sobriety. Controlled studies have revealed compelling evidence for alcohol-related brain structural and functional modification—some longstanding, some transient, and some compensatory. Patterns of circuitry disruption identified through structural and functional MRI studies suggest a central role for degradation of frontocerebellar neuronal nodes and connecting circuitry affecting widespread brain regions and contributing to alcoholism’s salient, enduring, and debilitating cognitive and motor deficits—executive dysfunction, visuospatial impairment, and ataxia. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 18241500 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=18241500 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-005-2267-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 583 Subjects: – SubjectFull: Alcoholism Type: general – SubjectFull: Brain Type: general – SubjectFull: Ataxia Type: general – SubjectFull: Neural circuitry Type: general – SubjectFull: Magnetic resonance imaging Type: general Titles: – TitleFull: Neurocircuitry in alcoholism: a substrate of disruption and repair. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sullivan, Edith V. – PersonEntity: Name: NameFull: Pfefferbaum, Adolf IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2005 Type: published Y: 2005 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 180 – Type: issue Value: 4 Titles: – TitleFull: Psychopharmacology Type: main |
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