Medications for Opioid Use Disorder in People Who Inject Substances: Reflection on the Potential Place of Morphine Sulfate as Substitution Treatment? Results of COSINUS Cohort Study.
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| Title: | Medications for Opioid Use Disorder in People Who Inject Substances: Reflection on the Potential Place of Morphine Sulfate as Substitution Treatment? Results of COSINUS Cohort Study. |
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| Authors: | Lalanne, Laurence (AUTHOR), Davalos, Julio Ricardo (AUTHOR), Audran, Martin (AUTHOR), Hamelin, Naomi (AUTHOR), Chauvin, Carole (AUTHOR), Briand-Madrid, Laelia (AUTHOR), Kervran, Charlotte (AUTHOR), Kirchherr, Sébastien (AUTHOR), Auriacombe, Marc (AUTHOR), Roux, Perrine (AUTHOR), Jauffret-Roustide, Marie (AUTHOR) |
| Source: | Substance Use & Misuse. 2025, Vol. 60 Issue 3, p393-402. 10p. |
| Subjects: | Substance abuse, Cocaine, Intravenous drug abuse, Morphine, Research funding, Harm reduction, Heroin, Drugs, Drug abusers |
| Abstract: | Background: Opioid Use Disorder (OUD) often provokes dramatic consequences in terms of increased morbi-mortality. Two medications have mainly been worldwide used for OUD (MOUD), buprenorphine and methadone. Recently, however, some reports have highlighted the use of Morphine Sulfate (MS) mainly obtained without a prescription but used as MOUD by opioid users and especially People Who Inject Substances (PWIS). We propose to characterize the prevalence and distribution of MOUD and MS use in PWIS. Methods: This study examines the use of MOUD and MS amongst French PWIS recruited in harm reduction facilities and drug consumption rooms in the context of the COSINUS (Cohort to assess structural and individual factors in drug use) study. Results: MOUD are prescribed, respectively, to one-third and one-fifth of PWIS, whereas a half of them declared MS consumption without prescription. MS users live with higher precariousness and are younger than non-users. MS is associated with salt cocaine and heroin use. It is often consumed with methadone and more rarely with buprenorphine and we hypothesized that this is probably linked to buprenorphine's pharmacological antagonism. Discussion: Our results show the high prevalence of MS consumption and highlight the importance of considering the highly restricted possibility of prescribing MS as MOUD. Its association with methadone raises the question of their synergistic action on craving and mental disorders. The profiles of opioid users who could benefit from MS with or without methadone must be examined to improve their care but with the utmost caution, given the risk of overdose. [ABSTRACT FROM AUTHOR] |
| Copyright of Substance Use & Misuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 182438313 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Medications for Opioid Use Disorder in People Who Inject Substances: Reflection on the Potential Place of Morphine Sulfate as Substitution Treatment? Results of COSINUS Cohort Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lalanne%2C+Laurence%22">Lalanne, Laurence</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Davalos%2C+Julio+Ricardo%22">Davalos, Julio Ricardo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Audran%2C+Martin%22">Audran, Martin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hamelin%2C+Naomi%22">Hamelin, Naomi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chauvin%2C+Carole%22">Chauvin, Carole</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Briand-Madrid%2C+Laelia%22">Briand-Madrid, Laelia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kervran%2C+Charlotte%22">Kervran, Charlotte</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kirchherr%2C+Sébastien%22">Kirchherr, Sébastien</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Auriacombe%2C+Marc%22">Auriacombe, Marc</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roux%2C+Perrine%22">Roux, Perrine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jauffret-Roustide%2C+Marie%22">Jauffret-Roustide, Marie</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Substance+Use+%26+Misuse%22">Substance Use & Misuse</searchLink>. 2025, Vol. 60 Issue 3, p393-402. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Substance+abuse%22">Substance abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Cocaine%22">Cocaine</searchLink><br /><searchLink fieldCode="DE" term="%22Intravenous+drug+abuse%22">Intravenous drug abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Morphine%22">Morphine</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Harm+reduction%22">Harm reduction</searchLink><br /><searchLink fieldCode="DE" term="%22Heroin%22">Heroin</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+abusers%22">Drug abusers</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Opioid Use Disorder (OUD) often provokes dramatic consequences in terms of increased morbi-mortality. Two medications have mainly been worldwide used for OUD (MOUD), buprenorphine and methadone. Recently, however, some reports have highlighted the use of Morphine Sulfate (MS) mainly obtained without a prescription but used as MOUD by opioid users and especially People Who Inject Substances (PWIS). We propose to characterize the prevalence and distribution of MOUD and MS use in PWIS. Methods: This study examines the use of MOUD and MS amongst French PWIS recruited in harm reduction facilities and drug consumption rooms in the context of the COSINUS (Cohort to assess structural and individual factors in drug use) study. Results: MOUD are prescribed, respectively, to one-third and one-fifth of PWIS, whereas a half of them declared MS consumption without prescription. MS users live with higher precariousness and are younger than non-users. MS is associated with salt cocaine and heroin use. It is often consumed with methadone and more rarely with buprenorphine and we hypothesized that this is probably linked to buprenorphine's pharmacological antagonism. Discussion: Our results show the high prevalence of MS consumption and highlight the importance of considering the highly restricted possibility of prescribing MS as MOUD. Its association with methadone raises the question of their synergistic action on craving and mental disorders. The profiles of opioid users who could benefit from MS with or without methadone must be examined to improve their care but with the utmost caution, given the risk of overdose. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Substance Use & Misuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/10826084.2024.2434005 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 393 Subjects: – SubjectFull: Substance abuse Type: general – SubjectFull: Cocaine Type: general – SubjectFull: Intravenous drug abuse Type: general – SubjectFull: Morphine Type: general – SubjectFull: Research funding Type: general – SubjectFull: Harm reduction Type: general – SubjectFull: Heroin Type: general – SubjectFull: Drugs Type: general – SubjectFull: Drug abusers Type: general Titles: – TitleFull: Medications for Opioid Use Disorder in People Who Inject Substances: Reflection on the Potential Place of Morphine Sulfate as Substitution Treatment? Results of COSINUS Cohort Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lalanne, Laurence – PersonEntity: Name: NameFull: Davalos, Julio Ricardo – PersonEntity: Name: NameFull: Audran, Martin – PersonEntity: Name: NameFull: Hamelin, Naomi – PersonEntity: Name: NameFull: Chauvin, Carole – PersonEntity: Name: NameFull: Briand-Madrid, Laelia – PersonEntity: Name: NameFull: Kervran, Charlotte – PersonEntity: Name: NameFull: Kirchherr, Sébastien – PersonEntity: Name: NameFull: Auriacombe, Marc – PersonEntity: Name: NameFull: Roux, Perrine – PersonEntity: Name: NameFull: Jauffret-Roustide, Marie IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 10826084 Numbering: – Type: volume Value: 60 – Type: issue Value: 3 Titles: – TitleFull: Substance Use & Misuse Type: main |
| ResultId | 1 |
