A landscape review to identify what matters to patients with thrombotic cardiovascular diseases and patient-reported outcome instruments which can be used to capture the patient experience.
Saved in:
| Title: | A landscape review to identify what matters to patients with thrombotic cardiovascular diseases and patient-reported outcome instruments which can be used to capture the patient experience. |
|---|---|
| Authors: | Barsdorf, Alexandra I. (AUTHOR), Fastenau, John (AUTHOR), Lee, Shannon (AUTHOR), Li, Xiaoyan (AUTHOR), O'Brien, Ellen (AUTHOR), Stevenson, Blue (AUTHOR), Becker, Brandon (AUTHOR) |
| Source: | Quality of Life Research. Jan2025, Vol. 34 Issue 1, p101-111. 11p. |
| Subjects: | Patients' attitudes, Patient experience, Acute coronary syndrome, Patient reported outcome measures, Medical sciences |
| Abstract: | Purpose: Thrombotic cardiovascular diseases profoundly impact patients' health-related quality of life (HRQoL). However, patient-reported outcome (PRO) instruments that are disease-specific or antithrombotic-treatment focused, developed according to US Food and Drug Administration (FDA) guidance on PROs, and can be used in clinical trials, are lacking. The aim of this study was to understand concepts important to patients diagnosed with coronary artery disease (CAD) or acute coronary syndrome (ACS), atrial fibrillation (AF), or stroke who require antithrombotic treatment for reducing risk of future thrombotic events (indications being evaluated for an investigational new drug), identify PROs that measure relevant symptoms and impacts, and determine acceptability of PROs from a health technology assessment (HTA) perspective. Methods: A landscape review, conducted between January 2009 and October 2020, included a search of qualitative literature (OVID), a review of PRO instruments using multiple sources (e.g., OVID and clinical trials databases), and a survey of HTA decisions for antithrombotic medications. Results: The qualitative literature review identified 27 publications used to develop a high-level conceptual summary of symptoms and HRQoL impacts reported by patients. The instrument landscape review indicated that generic PROs have been utilized for thrombotic indications, but disease-specific, fit-for-purpose instruments are lacking, and the HTA review revealed that although HTA agencies discussed PRO instruments, evidence of specific recommendations was not found. Conclusion: To ensure patients' experiences, perspectives, and priorities are incorporated into drug development and evaluation, a core set of PROs for thrombotic indications that meet health authority guidance and are acceptable to HTA agencies is needed. [ABSTRACT FROM AUTHOR] |
| Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 182843562 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: A landscape review to identify what matters to patients with thrombotic cardiovascular diseases and patient-reported outcome instruments which can be used to capture the patient experience. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Barsdorf%2C+Alexandra+I%2E%22">Barsdorf, Alexandra I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fastenau%2C+John%22">Fastenau, John</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Shannon%22">Lee, Shannon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Xiaoyan%22">Li, Xiaoyan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22O'Brien%2C+Ellen%22">O'Brien, Ellen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stevenson%2C+Blue%22">Stevenson, Blue</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Becker%2C+Brandon%22">Becker, Brandon</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Jan2025, Vol. 34 Issue 1, p101-111. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Patients'+attitudes%22">Patients' attitudes</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+experience%22">Patient experience</searchLink><br /><searchLink fieldCode="DE" term="%22Acute+coronary+syndrome%22">Acute coronary syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+reported+outcome+measures%22">Patient reported outcome measures</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+sciences%22">Medical sciences</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Thrombotic cardiovascular diseases profoundly impact patients' health-related quality of life (HRQoL). However, patient-reported outcome (PRO) instruments that are disease-specific or antithrombotic-treatment focused, developed according to US Food and Drug Administration (FDA) guidance on PROs, and can be used in clinical trials, are lacking. The aim of this study was to understand concepts important to patients diagnosed with coronary artery disease (CAD) or acute coronary syndrome (ACS), atrial fibrillation (AF), or stroke who require antithrombotic treatment for reducing risk of future thrombotic events (indications being evaluated for an investigational new drug), identify PROs that measure relevant symptoms and impacts, and determine acceptability of PROs from a health technology assessment (HTA) perspective. Methods: A landscape review, conducted between January 2009 and October 2020, included a search of qualitative literature (OVID), a review of PRO instruments using multiple sources (e.g., OVID and clinical trials databases), and a survey of HTA decisions for antithrombotic medications. Results: The qualitative literature review identified 27 publications used to develop a high-level conceptual summary of symptoms and HRQoL impacts reported by patients. The instrument landscape review indicated that generic PROs have been utilized for thrombotic indications, but disease-specific, fit-for-purpose instruments are lacking, and the HTA review revealed that although HTA agencies discussed PRO instruments, evidence of specific recommendations was not found. Conclusion: To ensure patients' experiences, perspectives, and priorities are incorporated into drug development and evaluation, a core set of PROs for thrombotic indications that meet health authority guidance and are acceptable to HTA agencies is needed. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=182843562 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11136-024-03790-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 101 Subjects: – SubjectFull: Patients' attitudes Type: general – SubjectFull: Patient experience Type: general – SubjectFull: Acute coronary syndrome Type: general – SubjectFull: Patient reported outcome measures Type: general – SubjectFull: Medical sciences Type: general Titles: – TitleFull: A landscape review to identify what matters to patients with thrombotic cardiovascular diseases and patient-reported outcome instruments which can be used to capture the patient experience. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Barsdorf, Alexandra I. – PersonEntity: Name: NameFull: Fastenau, John – PersonEntity: Name: NameFull: Lee, Shannon – PersonEntity: Name: NameFull: Li, Xiaoyan – PersonEntity: Name: NameFull: O'Brien, Ellen – PersonEntity: Name: NameFull: Stevenson, Blue – PersonEntity: Name: NameFull: Becker, Brandon IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09629343 Numbering: – Type: volume Value: 34 – Type: issue Value: 1 Titles: – TitleFull: Quality of Life Research Type: main |
| ResultId | 1 |
