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Efficacy of interventional closure therapy on cryptogenic stroke with coexisting patent foramen ovale in young patients and its impact on serum fibrinogen and D-dimer levels.

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Title: Efficacy of interventional closure therapy on cryptogenic stroke with coexisting patent foramen ovale in young patients and its impact on serum fibrinogen and D-dimer levels.
Authors: Yu, Kai (AUTHOR), Li, Yaoru (AUTHOR), Wang, Ce (AUTHOR), Fu, Jinguo (AUTHOR), Hu, Yaping (AUTHOR), Wang, Lei (AUTHOR), Zhang, Jun (AUTHOR)
Source: International Journal of Neuroscience. Mar2025, Vol. 135 Issue 3, p272-279. 8p.
Subjects: Patent foramen ovale, Ischemic stroke, Blood coagulation, Fibrinogen, Fibrin fragment D
Abstract: Objective: To explore the efficacy of interventional closure therapy in young patients with cryptogenic stroke and coexisting patent foramen ovale and analyze its impact on serum fibrinogen and D-dimer levels. Methods: All subjects in this study were young stroke patients with PFO. After excluding patients who did not meet the inclusion criteria, they were registered and divided into two groups based on the treatment method: the closure group and the medical group. Results: There were no significant differences in basic clinical data between the two groups, indicating comparability (p > 0.05). The closure group showed better heart function after treatment compared to the medical group, with significant differences (p < 0.05). Headache symptoms in the closure group were less severe than those in the medical group after treatment, with significant differences (p < 0.05). Laboratory indicators in the closure group were better than those in the medical group after treatment, with significant differences (p < 0.05). Serum fibrinogen and D-dimer levels in the closure group were lower than those in the medical group after treatment, with significant differences (p < 0.05). Conclusion: Interventional closure therapy demonstrated positive effects on young patients with cryptogenic stroke and coexisting PFO, showing improvements in heart function, headache symptoms, and blood coagulation parameters. While the study suggests potential benefits, cautious interpretation is warranted, given the observational study design. Further research with a larger sample size and long-term follow-up is needed to validate these findings. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Efficacy of interventional closure therapy on cryptogenic stroke with coexisting patent foramen ovale in young patients and its impact on serum fibrinogen and D-dimer levels.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yu%2C+Kai%22&quot;&gt;Yu, Kai&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Yaoru%22&quot;&gt;Li, Yaoru&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang%2C+Ce%22&quot;&gt;Wang, Ce&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fu%2C+Jinguo%22&quot;&gt;Fu, Jinguo&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hu%2C+Yaping%22&quot;&gt;Hu, Yaping&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang%2C+Lei%22&quot;&gt;Wang, Lei&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Jun%22&quot;&gt;Zhang, Jun&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Neuroscience%22&quot;&gt;International Journal of Neuroscience&lt;/searchLink&gt;. Mar2025, Vol. 135 Issue 3, p272-279. 8p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Patent+foramen+ovale%22&quot;&gt;Patent foramen ovale&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Ischemic+stroke%22&quot;&gt;Ischemic stroke&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Blood+coagulation%22&quot;&gt;Blood coagulation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Fibrinogen%22&quot;&gt;Fibrinogen&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Fibrin+fragment+D%22&quot;&gt;Fibrin fragment D&lt;/searchLink&gt;
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  Label: Abstract
  Group: Ab
  Data: Objective: To explore the efficacy of interventional closure therapy in young patients with cryptogenic stroke and coexisting patent foramen ovale and analyze its impact on serum fibrinogen and D-dimer levels. Methods: All subjects in this study were young stroke patients with PFO. After excluding patients who did not meet the inclusion criteria, they were registered and divided into two groups based on the treatment method: the closure group and the medical group. Results: There were no significant differences in basic clinical data between the two groups, indicating comparability (p &gt; 0.05). The closure group showed better heart function after treatment compared to the medical group, with significant differences (p &lt; 0.05). Headache symptoms in the closure group were less severe than those in the medical group after treatment, with significant differences (p &lt; 0.05). Laboratory indicators in the closure group were better than those in the medical group after treatment, with significant differences (p &lt; 0.05). Serum fibrinogen and D-dimer levels in the closure group were lower than those in the medical group after treatment, with significant differences (p &lt; 0.05). Conclusion: Interventional closure therapy demonstrated positive effects on young patients with cryptogenic stroke and coexisting PFO, showing improvements in heart function, headache symptoms, and blood coagulation parameters. While the study suggests potential benefits, cautious interpretation is warranted, given the observational study design. Further research with a larger sample size and long-term follow-up is needed to validate these findings. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of International Journal of Neuroscience is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/00207454.2023.2298714
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 8
        StartPage: 272
    Subjects:
      – SubjectFull: Patent foramen ovale
        Type: general
      – SubjectFull: Ischemic stroke
        Type: general
      – SubjectFull: Blood coagulation
        Type: general
      – SubjectFull: Fibrinogen
        Type: general
      – SubjectFull: Fibrin fragment D
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      – TitleFull: Efficacy of interventional closure therapy on cryptogenic stroke with coexisting patent foramen ovale in young patients and its impact on serum fibrinogen and D-dimer levels.
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            NameFull: Yu, Kai
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              M: 03
              Text: Mar2025
              Type: published
              Y: 2025
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