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Assessing genetic conservation of human sociability-linked genes in C. elegans.

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Title: Assessing genetic conservation of human sociability-linked genes in C. elegans.
Authors: Roozen, Mila C. (AUTHOR), Kas, Martien J. H. (AUTHOR)
Source: Behavior Genetics. Mar2025, Vol. 55 Issue 2, p141-152. 12p.
Subjects: Human genetic variation, Activin receptors, Human genes, Animal species, Life sciences, Caenorhabditis elegans
Abstract: Social behavior is a common though variable trait across animal species. How much of the variation in social behavior is due to biological common mechanisms across animal species is unknown. In this study we examined to what extent human genetic variation in sociability is affected by pathways shared with Caenorhabditis elegans and whether any conserved sociability-linked genes show enhanced levels of essential functions and interactivity. We found inconsistent evidence of increased conservation with more thorough analyses resulting in no evidence of increased conservation of human sociability-linked genes. Conserved genes were highly interactive compared to nonconserved and random genes, while only a limited number of genetic interactions were found to be conserved. No evidence was found for enrichment of social phenotypes in C. elegans orthologs of human sociability-linked genes while evidence for associations with essential functions were limited. The activin A receptor type 2A (ACVR2A) gene appears to play a role in social behavior in both humans and C. elegans, making it an interesting gene for further study. [ABSTRACT FROM AUTHOR]
Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Assessing genetic conservation of human sociability-linked genes in C. elegans.
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  Data: <searchLink fieldCode="AR" term="%22Roozen%2C+Mila+C%2E%22">Roozen, Mila C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kas%2C+Martien+J%2E+H%2E%22">Kas, Martien J. H.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Behavior+Genetics%22">Behavior Genetics</searchLink>. Mar2025, Vol. 55 Issue 2, p141-152. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Human+genetic+variation%22">Human genetic variation</searchLink><br /><searchLink fieldCode="DE" term="%22Activin+receptors%22">Activin receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Human+genes%22">Human genes</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+species%22">Animal species</searchLink><br /><searchLink fieldCode="DE" term="%22Life+sciences%22">Life sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Caenorhabditis+elegans%22">Caenorhabditis elegans</searchLink>
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  Data: Social behavior is a common though variable trait across animal species. How much of the variation in social behavior is due to biological common mechanisms across animal species is unknown. In this study we examined to what extent human genetic variation in sociability is affected by pathways shared with Caenorhabditis elegans and whether any conserved sociability-linked genes show enhanced levels of essential functions and interactivity. We found inconsistent evidence of increased conservation with more thorough analyses resulting in no evidence of increased conservation of human sociability-linked genes. Conserved genes were highly interactive compared to nonconserved and random genes, while only a limited number of genetic interactions were found to be conserved. No evidence was found for enrichment of social phenotypes in C. elegans orthologs of human sociability-linked genes while evidence for associations with essential functions were limited. The activin A receptor type 2A (ACVR2A) gene appears to play a role in social behavior in both humans and C. elegans, making it an interesting gene for further study. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Mar2025
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