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Psychotic attack during the clinical course of megalencephalic leukoencephalopathy with subcortical cysts: a case report.

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Title: Psychotic attack during the clinical course of megalencephalic leukoencephalopathy with subcortical cysts: a case report.
Authors: Avşar, Pınar Aydoğan, Akçay, Elif, Gürkaş, Esra
Source: European Child & Adolescent Psychiatry. Mar2025, Vol. 34 Issue 3, p1075-1080. 6p.
Subjects: Drug therapy for psychoses, Delusions, Piperidine, Affective disorders, Brain diseases, Risperidone, Cysts (Pathology), Hallucinations, Psychoses, Craniofacial abnormalities
Abstract: Objectives: Van der Knaap disease or megalencephalic leukoencephalopathy with subcortical cysts (MLC), is a slowly progressive neurodegenerative disease with macrocephaly. We present a case of MLC with a confirmed homozygous MLC1 mutation who presented with a psychotic attack at a very young age. Case presentation: An 11-year-old girl was admitted to the emergency room with delusions, hallucinations, and irritability. She was diagnosed with MLC at 18 months old. Her psychotic symptoms were improved with the administration of risperidone treatment added to her valproic acid treatment for EEG abnormality. Conclusion: In this case study we reported the first episode of a psychotic attack during the clinical course of MLC. This case indicates the possibility that MLC influences the onset of the psychotic attack. Further investigation with more patients is needed to identify the relationship. [ABSTRACT FROM AUTHOR]
Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Psychotic attack during the clinical course of megalencephalic leukoencephalopathy with subcortical cysts: a case report.
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  Data: <searchLink fieldCode="AR" term="%22Avşar%2C+Pınar+Aydoğan%22">Avşar, Pınar Aydoğan</searchLink><br /><searchLink fieldCode="AR" term="%22Akçay%2C+Elif%22">Akçay, Elif</searchLink><br /><searchLink fieldCode="AR" term="%22Gürkaş%2C+Esra%22">Gürkaş, Esra</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. Mar2025, Vol. 34 Issue 3, p1075-1080. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Drug+therapy+for+psychoses%22">Drug therapy for psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Delusions%22">Delusions</searchLink><br /><searchLink fieldCode="DE" term="%22Piperidine%22">Piperidine</searchLink><br /><searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+diseases%22">Brain diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Risperidone%22">Risperidone</searchLink><br /><searchLink fieldCode="DE" term="%22Cysts+%28Pathology%29%22">Cysts (Pathology)</searchLink><br /><searchLink fieldCode="DE" term="%22Hallucinations%22">Hallucinations</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Craniofacial+abnormalities%22">Craniofacial abnormalities</searchLink>
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  Label: Abstract
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  Data: Objectives: Van der Knaap disease or megalencephalic leukoencephalopathy with subcortical cysts (MLC), is a slowly progressive neurodegenerative disease with macrocephaly. We present a case of MLC with a confirmed homozygous MLC1 mutation who presented with a psychotic attack at a very young age. Case presentation: An 11-year-old girl was admitted to the emergency room with delusions, hallucinations, and irritability. She was diagnosed with MLC at 18 months old. Her psychotic symptoms were improved with the administration of risperidone treatment added to her valproic acid treatment for EEG abnormality. Conclusion: In this case study we reported the first episode of a psychotic attack during the clinical course of MLC. This case indicates the possibility that MLC influences the onset of the psychotic attack. Further investigation with more patients is needed to identify the relationship. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00787-024-02539-y
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        Text: English
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        Type: general
      – SubjectFull: Delusions
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      – SubjectFull: Piperidine
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      – SubjectFull: Cysts (Pathology)
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      – SubjectFull: Psychoses
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      – SubjectFull: Craniofacial abnormalities
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      – TitleFull: Psychotic attack during the clinical course of megalencephalic leukoencephalopathy with subcortical cysts: a case report.
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              Text: Mar2025
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