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Mood, Activity, and Instability in Bipolar Disorder and Unipolar Disorder—An Exploratory Post Hoc Study Using Digital Data.

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Title: Mood, Activity, and Instability in Bipolar Disorder and Unipolar Disorder—An Exploratory Post Hoc Study Using Digital Data.
Authors: Faurholt‐Jepsen, Maria (AUTHOR), Busk, Jonas (AUTHOR), Tønning, Morten Lindberg (AUTHOR), Rohani, Darius (AUTHOR), Bardram, Jakob Eyvind (AUTHOR), Kessing, Lars Vedel (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Mar2025, Vol. 151 Issue 3, p426-433. 8p.
Subjects: Statistical significance, Bipolar disorder, Affective disorders, Square root, Regression analysis
Abstract: Background: Mood, activity, and instability in symptomatology hold significant roles in bipolar disorder (BD) and unipolar disorder (UD). The objectives were to examine disparities in these symptoms among patients with BD and UD. Methods: Data from two studies including patients with BD and UD, respectively, were combined for exploratory analyses. Patients provided daily smartphone‐based evaluations of mood and activity/energy for a 6‐month period. A total of 47 patients with BD and 59 patients with UD were included in the analyses. The dataset contains more than 13,000 patient‐reported evaluations of mood and activity. Daily mood and activity instability measures were calculated using the root squared successive difference method. Results: In linear mixed effect regression models adjusted for age, sex, and work status, there were statistically significant lower levels of activity in patients with BD as compared with patients with UD overall, during euthymic states and during depressive states (B: −0.61, 95% CI: −0.98; −0.24, p = 0.001). There were no statistically significant differences in mood instability and activity instability between patients with BD and patients with UD overall, during euthymic states and during depressive states, when accounting for multiple testing (p > 0.012). Limitations: Analyses were exploratory and post hoc. Findings should be interpreted with caution. The sample size was modest. Conclusion: Patients with BD presented with lower level of activity as compared with patients with UD. There were no differences in mood and activity instability between these groups. Future studies including larger sample sizes should investigate differences between BD and UD. Trial Registration: ClinicalTrials.gov identifier: NCT03033420 [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Mood, Activity, and Instability in Bipolar Disorder and Unipolar Disorder—An Exploratory Post Hoc Study Using Digital Data.
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Mar2025, Vol. 151 Issue 3, p426-433. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Statistical+significance%22">Statistical significance</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Square+root%22">Square root</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink>
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  Data: Background: Mood, activity, and instability in symptomatology hold significant roles in bipolar disorder (BD) and unipolar disorder (UD). The objectives were to examine disparities in these symptoms among patients with BD and UD. Methods: Data from two studies including patients with BD and UD, respectively, were combined for exploratory analyses. Patients provided daily smartphone‐based evaluations of mood and activity/energy for a 6‐month period. A total of 47 patients with BD and 59 patients with UD were included in the analyses. The dataset contains more than 13,000 patient‐reported evaluations of mood and activity. Daily mood and activity instability measures were calculated using the root squared successive difference method. Results: In linear mixed effect regression models adjusted for age, sex, and work status, there were statistically significant lower levels of activity in patients with BD as compared with patients with UD overall, during euthymic states and during depressive states (B: −0.61, 95% CI: −0.98; −0.24, p = 0.001). There were no statistically significant differences in mood instability and activity instability between patients with BD and patients with UD overall, during euthymic states and during depressive states, when accounting for multiple testing (p > 0.012). Limitations: Analyses were exploratory and post hoc. Findings should be interpreted with caution. The sample size was modest. Conclusion: Patients with BD presented with lower level of activity as compared with patients with UD. There were no differences in mood and activity instability between these groups. Future studies including larger sample sizes should investigate differences between BD and UD. Trial Registration: ClinicalTrials.gov identifier: NCT03033420 [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Mar2025
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