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Health state utilities associated with invasive pneumococcal disease, pneumonia, and recurrent acute otitis media in young children.

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Title: Health state utilities associated with invasive pneumococcal disease, pneumonia, and recurrent acute otitis media in young children.
Authors: Matza, Louis S. (AUTHOR), Howell, Timothy A. (AUTHOR), Chun, Bianca (AUTHOR), Hetherington, Lucinda (AUTHOR), White, Meghan (AUTHOR), Weiss, Thomas (AUTHOR), Huang, Min (AUTHOR), Rowen, Donna (AUTHOR), Tan, Tina (AUTHOR), Feemster, Kristen (AUTHOR), Nozad, Bayad (AUTHOR), Kelly, Matthew S. (AUTHOR), Hoberman, Alejandro (AUTHOR), Mohanty, Salini (AUTHOR)
Source: Quality of Life Research. Mar2025, Vol. 34 Issue 3, p809-821. 13p.
Subjects: Pneumococcal pneumonia, Pneumonia, Communicable diseases, Toddlers, Bacteremia, Acute otitis media, Cost effectiveness, Patient reported outcome measures
Abstract: Purpose: Cost-utility analyses examining the value of new vaccines for pneumococcal disease will require health state utilities as inputs. Existing utilities for pneumococcal infections in young children are limited. The purpose of this study was to estimate health state utilities associated with pneumococcal infections in young children. Methods: Six health state vignettes depicting infections due to Streptococcus pneumoniae were drafted based on published literature and clinician interviews. To address methodological challenges in estimating utilities for temporary infections in children 0–5 years of age, several time trade-off approaches were explored in a pilot study (N = 28 participants). In the subsequent utility elicitation study conducted in the UK, health states were valued using the best performing method from the pilot (10-year time horizon, with infections repeated annually) with adult general population respondents imagining a child 2–5 years of age. Results: A total of 208 participants completed interviews (51.9% female; mean [SD] age = 41.0 [14.9] years). Mean (SD) utilities were 0.902 (0.092) for pneumonia requiring hospitalization, 0.901 (0.087) for bacteremia, 0.894 (0.103) for recurrent acute otitis media (AOM), 0.882 (0.107) for recurrent AOM treated with pressure equalization tubes, 0.878 (0.109) for bacteremic pneumonia, and 0.809 (0.145) for meningitis. Conclusion: Lower health state utilities were associated with health states that had longer treatment periods, required more invasive treatment, and described more severe infections. Utilities from this study can be used in models examining cost-effectiveness of pneumococcal vaccines. These results have methodological implications for future research estimating utilities associated with temporary pediatric health conditions. [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Health state utilities associated with invasive pneumococcal disease, pneumonia, and recurrent acute otitis media in young children.
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  Data: <searchLink fieldCode="AR" term="%22Matza%2C+Louis+S%2E%22">Matza, Louis S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Howell%2C+Timothy+A%2E%22">Howell, Timothy A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chun%2C+Bianca%22">Chun, Bianca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hetherington%2C+Lucinda%22">Hetherington, Lucinda</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22White%2C+Meghan%22">White, Meghan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Weiss%2C+Thomas%22">Weiss, Thomas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Min%22">Huang, Min</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rowen%2C+Donna%22">Rowen, Donna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tan%2C+Tina%22">Tan, Tina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Feemster%2C+Kristen%22">Feemster, Kristen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nozad%2C+Bayad%22">Nozad, Bayad</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kelly%2C+Matthew+S%2E%22">Kelly, Matthew S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hoberman%2C+Alejandro%22">Hoberman, Alejandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mohanty%2C+Salini%22">Mohanty, Salini</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="DE" term="%22Pneumococcal+pneumonia%22">Pneumococcal pneumonia</searchLink><br /><searchLink fieldCode="DE" term="%22Pneumonia%22">Pneumonia</searchLink><br /><searchLink fieldCode="DE" term="%22Communicable+diseases%22">Communicable diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Toddlers%22">Toddlers</searchLink><br /><searchLink fieldCode="DE" term="%22Bacteremia%22">Bacteremia</searchLink><br /><searchLink fieldCode="DE" term="%22Acute+otitis+media%22">Acute otitis media</searchLink><br /><searchLink fieldCode="DE" term="%22Cost+effectiveness%22">Cost effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+reported+outcome+measures%22">Patient reported outcome measures</searchLink>
– Name: Abstract
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  Data: Purpose: Cost-utility analyses examining the value of new vaccines for pneumococcal disease will require health state utilities as inputs. Existing utilities for pneumococcal infections in young children are limited. The purpose of this study was to estimate health state utilities associated with pneumococcal infections in young children. Methods: Six health state vignettes depicting infections due to Streptococcus pneumoniae were drafted based on published literature and clinician interviews. To address methodological challenges in estimating utilities for temporary infections in children 0–5 years of age, several time trade-off approaches were explored in a pilot study (N = 28 participants). In the subsequent utility elicitation study conducted in the UK, health states were valued using the best performing method from the pilot (10-year time horizon, with infections repeated annually) with adult general population respondents imagining a child 2–5 years of age. Results: A total of 208 participants completed interviews (51.9% female; mean [SD] age = 41.0 [14.9] years). Mean (SD) utilities were 0.902 (0.092) for pneumonia requiring hospitalization, 0.901 (0.087) for bacteremia, 0.894 (0.103) for recurrent acute otitis media (AOM), 0.882 (0.107) for recurrent AOM treated with pressure equalization tubes, 0.878 (0.109) for bacteremic pneumonia, and 0.809 (0.145) for meningitis. Conclusion: Lower health state utilities were associated with health states that had longer treatment periods, required more invasive treatment, and described more severe infections. Utilities from this study can be used in models examining cost-effectiveness of pneumococcal vaccines. These results have methodological implications for future research estimating utilities associated with temporary pediatric health conditions. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s11136-024-03840-8
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      – Code: eng
        Text: English
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    Subjects:
      – SubjectFull: Pneumococcal pneumonia
        Type: general
      – SubjectFull: Pneumonia
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      – SubjectFull: Communicable diseases
        Type: general
      – SubjectFull: Toddlers
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      – SubjectFull: Bacteremia
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      – SubjectFull: Acute otitis media
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      – SubjectFull: Cost effectiveness
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              Text: Mar2025
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