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Choroid plexus tumors in adults: a retrospective mono-institutional study.

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Title: Choroid plexus tumors in adults: a retrospective mono-institutional study.
Authors: Anghileri, Elena (AUTHOR), Gaviani, Paola (AUTHOR), Amato, Anna (AUTHOR), Pollo, Bianca (AUTHOR), Paterra, Rosina (AUTHOR), Marchetti, Marcello (AUTHOR), Doniselli, Fabio M. (AUTHOR), Restelli, Francesco (AUTHOR), Eoli, Marica (AUTHOR), de Oliveira Muniz Koch, Ludmila (AUTHOR), Redaelli, Veronica (AUTHOR), Botturi, Andrea Giorgio (AUTHOR), DiMeco, Francesco (AUTHOR), Ferroli, Paolo (AUTHOR), Farinotti, Mariangela (AUTHOR), Silvani, Antonio (AUTHOR)
Source: Neurological Sciences. Apr2025, Vol. 46 Issue 4, p1859-1866. 8p.
Subjects: Choroid plexus, Intracranial hypertension, Cranial nerves, Overall survival, Tumor grading
Abstract: Purpose: Choroid plexus tumors (CPT) are rare entities, and even rarer in adulthood. Methods: A retrospective consecutive series of 24 adult CPT patients was reviewed. Results: We described 24 adult CPTs. Clinical onset included cerebellar signs (n = 11, 45.8%), intracranial hypertension signs (n = 8, 33.4%), cranial nerves impairment (n = 5, 20.8%), incidental findings (n = 4, 16.6%), seizures (n = 1, 4.2%), spinal signs (n = 1, 4.2%). At first diagnosis, CPT was mostly located in the ventricular system, but other locations can occur, including the spine (one case); meningeal involvement was present in one, pre-surgical hydrocephalus in one case only. CPT histological grade ranged from grade 1 (n = 17), grade 2 (n = 6), and grade 3 (n = 1). TERTp mutation was detected in 17.6% (n = 3/17). TP53 mutation in 5.9% (n = 1/17). Gross Total, Subtotal, Partial resection and Biopsy were achieved in 17 (70.8%), 3 (12.5%), 3 (12.5%) and 1 (4.2%) of patients, respectively. 76% of cases (n = 16/21) experienced clinical worsening suddenly after surgery for different reasons, and mostly gradually recovered. For three cases no data was available. Adjuvant therapy was performed only for grades 2 and 3. At recurrence, surgery, radiosurgery, radiotherapy and chemotherapy were considered. The median Overall Survival from surgery was 219.25 months (95% CI, 188.83–249.67). Conclusions: We confirm that CPT can occur in adults and are mostly grade 1 tumors located in the ventricular system. The surgical approach is the gold standard, although 76% of clinical worsening occurred, often transient. Adjuvant treatment was limited to higher grade CPT; however, no consensus has already been achieved about adjuvant therapy. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Choroid plexus tumors in adults: a retrospective mono-institutional study.
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  Data: <searchLink fieldCode="AR" term="%22Anghileri%2C+Elena%22">Anghileri, Elena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gaviani%2C+Paola%22">Gaviani, Paola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Amato%2C+Anna%22">Amato, Anna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pollo%2C+Bianca%22">Pollo, Bianca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Paterra%2C+Rosina%22">Paterra, Rosina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marchetti%2C+Marcello%22">Marchetti, Marcello</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Doniselli%2C+Fabio+M%2E%22">Doniselli, Fabio M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Restelli%2C+Francesco%22">Restelli, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eoli%2C+Marica%22">Eoli, Marica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Oliveira+Muniz+Koch%2C+Ludmila%22">de Oliveira Muniz Koch, Ludmila</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Redaelli%2C+Veronica%22">Redaelli, Veronica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Botturi%2C+Andrea+Giorgio%22">Botturi, Andrea Giorgio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22DiMeco%2C+Francesco%22">DiMeco, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferroli%2C+Paolo%22">Ferroli, Paolo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Farinotti%2C+Mariangela%22">Farinotti, Mariangela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silvani%2C+Antonio%22">Silvani, Antonio</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Apr2025, Vol. 46 Issue 4, p1859-1866. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Choroid+plexus%22">Choroid plexus</searchLink><br /><searchLink fieldCode="DE" term="%22Intracranial+hypertension%22">Intracranial hypertension</searchLink><br /><searchLink fieldCode="DE" term="%22Cranial+nerves%22">Cranial nerves</searchLink><br /><searchLink fieldCode="DE" term="%22Overall+survival%22">Overall survival</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+grading%22">Tumor grading</searchLink>
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  Label: Abstract
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  Data: Purpose: Choroid plexus tumors (CPT) are rare entities, and even rarer in adulthood. Methods: A retrospective consecutive series of 24 adult CPT patients was reviewed. Results: We described 24 adult CPTs. Clinical onset included cerebellar signs (n = 11, 45.8%), intracranial hypertension signs (n = 8, 33.4%), cranial nerves impairment (n = 5, 20.8%), incidental findings (n = 4, 16.6%), seizures (n = 1, 4.2%), spinal signs (n = 1, 4.2%). At first diagnosis, CPT was mostly located in the ventricular system, but other locations can occur, including the spine (one case); meningeal involvement was present in one, pre-surgical hydrocephalus in one case only. CPT histological grade ranged from grade 1 (n = 17), grade 2 (n = 6), and grade 3 (n = 1). TERTp mutation was detected in 17.6% (n = 3/17). TP53 mutation in 5.9% (n = 1/17). Gross Total, Subtotal, Partial resection and Biopsy were achieved in 17 (70.8%), 3 (12.5%), 3 (12.5%) and 1 (4.2%) of patients, respectively. 76% of cases (n = 16/21) experienced clinical worsening suddenly after surgery for different reasons, and mostly gradually recovered. For three cases no data was available. Adjuvant therapy was performed only for grades 2 and 3. At recurrence, surgery, radiosurgery, radiotherapy and chemotherapy were considered. The median Overall Survival from surgery was 219.25 months (95% CI, 188.83–249.67). Conclusions: We confirm that CPT can occur in adults and are mostly grade 1 tumors located in the ventricular system. The surgical approach is the gold standard, although 76% of clinical worsening occurred, often transient. Adjuvant treatment was limited to higher grade CPT; however, no consensus has already been achieved about adjuvant therapy. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-024-07894-x
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