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Electromechanical coupling across the gastroduodenal junction.

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Title: Electromechanical coupling across the gastroduodenal junction.
Authors: Simmonds, Sam (AUTHOR), Huizinga, Jan D. (AUTHOR), Taberner, Andrew J. (AUTHOR), Du, Peng (AUTHOR), Angeli‐Gordon, Timothy R. (AUTHOR)
Source: Acta Physiologica. Mar2025, Vol. 241 Issue 3, p1-13. 13p.
Subjects: Gastrointestinal system, Pylorus, Gastrointestinal diseases, Gastrointestinal surgery, Mechanical behavior of materials, Electromechanical effects, Biopotentials (Electrophysiology)
Abstract: The gastroduodenal junction is uniquely capable of regulating digestive functions in the gastrointestinal system. The pyloric sphincter, which demarcates the stomach from the small intestine, acts as a mechanical and electrical barrier, isolating each organ, thus enabling independent behaviors that are critical for proper digestion. Unique electrical patterns in the stomach, pylorus, and duodenum underpin the distinct contractile patterns of these regions, and improper organization of these mechanical behaviors leads to clinical conditions such as gastroparesis and dumping syndrome. For this reason, the gastroduodenal junction should be a focal point in investigations of novel biomarkers of gastrointestinal dysfunction. This review summarizes the current knowledge of bioelectrical and mechanical characteristics of the gastroduodenal junction, as well as the relevant underlying anatomy. As there is limited documentation of physiological recordings from the gastroduodenal junction of humans, inferences are made from animal studies and from measurements taken from other regions of the gastrointestinal tract, where appropriate. We suggest hypotheses on gastroduodenal electromechanical coupling and propose further studies to support or reject these ideas. Improved physiological understanding of this region, and the advent of novel diagnostic and therapeutic tools are crucial aspects for the future of clinical gastrointestinal medicine. [ABSTRACT FROM AUTHOR]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Electromechanical coupling across the gastroduodenal junction.
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  Data: <searchLink fieldCode="AR" term="%22Simmonds%2C+Sam%22">Simmonds, Sam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huizinga%2C+Jan+D%2E%22">Huizinga, Jan D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taberner%2C+Andrew+J%2E%22">Taberner, Andrew J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Du%2C+Peng%22">Du, Peng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Angeli‐Gordon%2C+Timothy+R%2E%22">Angeli‐Gordon, Timothy R.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Mar2025, Vol. 241 Issue 3, p1-13. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Gastrointestinal+system%22">Gastrointestinal system</searchLink><br /><searchLink fieldCode="DE" term="%22Pylorus%22">Pylorus</searchLink><br /><searchLink fieldCode="DE" term="%22Gastrointestinal+diseases%22">Gastrointestinal diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Gastrointestinal+surgery%22">Gastrointestinal surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanical+behavior+of+materials%22">Mechanical behavior of materials</searchLink><br /><searchLink fieldCode="DE" term="%22Electromechanical+effects%22">Electromechanical effects</searchLink><br /><searchLink fieldCode="DE" term="%22Biopotentials+%28Electrophysiology%29%22">Biopotentials (Electrophysiology)</searchLink>
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  Data: The gastroduodenal junction is uniquely capable of regulating digestive functions in the gastrointestinal system. The pyloric sphincter, which demarcates the stomach from the small intestine, acts as a mechanical and electrical barrier, isolating each organ, thus enabling independent behaviors that are critical for proper digestion. Unique electrical patterns in the stomach, pylorus, and duodenum underpin the distinct contractile patterns of these regions, and improper organization of these mechanical behaviors leads to clinical conditions such as gastroparesis and dumping syndrome. For this reason, the gastroduodenal junction should be a focal point in investigations of novel biomarkers of gastrointestinal dysfunction. This review summarizes the current knowledge of bioelectrical and mechanical characteristics of the gastroduodenal junction, as well as the relevant underlying anatomy. As there is limited documentation of physiological recordings from the gastroduodenal junction of humans, inferences are made from animal studies and from measurements taken from other regions of the gastrointestinal tract, where appropriate. We suggest hypotheses on gastroduodenal electromechanical coupling and propose further studies to support or reject these ideas. Improved physiological understanding of this region, and the advent of novel diagnostic and therapeutic tools are crucial aspects for the future of clinical gastrointestinal medicine. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/apha.70008
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        Text: English
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      – SubjectFull: Mechanical behavior of materials
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              Text: Mar2025
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              Y: 2025
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