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Repeatability of lipid layer thickness using LipiView® following removal of contact lenses and its relationship to comfort.

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Title: Repeatability of lipid layer thickness using LipiView® following removal of contact lenses and its relationship to comfort.
Authors: Kumar, Mukesh (AUTHOR), Masoudi, Simin (AUTHOR), Vijay, Ajay Kumar (AUTHOR), Naduvilath, Thomas John (AUTHOR), Dumpati, Srikanth (AUTHOR), Raj, Ankit (AUTHOR), Willcox, Mark (AUTHOR)
Source: Ophthalmic & Physiological Optics. Mar2025, Vol. 45 Issue 2, p383-390. 8p.
Subjects: Contact lenses, Soft contact lenses, Lipid analysis, Statistical reliability, Membrane lipids, Interferometers
Abstract: Purpose: To assess the repeatability of lipid layer thickness (LLT) measurement using the LipiView® interferometer after daily disposable contact lens (CL) wear and correlation with ocular comfort in soft contact lens wearers. Methods: A prospective study was conducted over two consecutive months, wherein CL wearers (n = 20) wore either Somofilcon A or Verofilcon A daily disposable CLs in a crossover design, switching lenses after 1 month. The pre‐corneal tear film LLT was measured at the end of each month after CLs had been worn for at least 6 h. Using the LipiView® interferometer, three measurements of the LLT (average, maximum and minimum) were recorded. Subjects' symptoms were evaluated with the Contact Lens Dry Eye Questionnaire‐8 (CLDEQ‐8) and correlations sought between post‐lens pre‐corneal tear film LLT and symptoms. Results: The average, maximum and minimum intraclass correlation coefficients (ICC) of LLT measurements at baseline were 0.57, 0.39 and 0.66, respectively, indicating poor (ICC < 0.4) to moderate (≥0.4, <0.75) repeatability. Coefficients of repeatability (CR) were 20.4, 24.8 and 20.8, respectively. After daily disposable CL wear, the ICC values were 0.66, 0.72 and 0.63 (indicating moderate repeatability), with CR values of 25.7, 32.0 and 23.3, respectively. Although all the ICC values of the pre‐corneal LLT increased after daily disposable lens wear indicating improved repeatability, the CR values also increased, indicating larger spread of data. However, in both cases, these increases were not significantly different from baseline. There were no significant differences in pre‐corneal LLT between the two lens types and no significant correlation with comfort scores (baseline: r = −0.11, p = 0.67; Verofilcon A lenses: r = 0.19, p = 0.45; Somofilcon A lenses r = 0.13, p = 0.62) for either lens. Conclusions: The repeatability of average, maximum and minimum LLT measurements performed by LipiView remained stable during CL wear. There was no significant correlation between LLT and comfort scores. [ABSTRACT FROM AUTHOR]
Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Repeatability of lipid layer thickness using LipiView&#174; following removal of contact lenses and its relationship to comfort.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kumar%2C+Mukesh%22&quot;&gt;Kumar, Mukesh&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Masoudi%2C+Simin%22&quot;&gt;Masoudi, Simin&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vijay%2C+Ajay+Kumar%22&quot;&gt;Vijay, Ajay Kumar&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Naduvilath%2C+Thomas+John%22&quot;&gt;Naduvilath, Thomas John&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dumpati%2C+Srikanth%22&quot;&gt;Dumpati, Srikanth&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Raj%2C+Ankit%22&quot;&gt;Raj, Ankit&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Willcox%2C+Mark%22&quot;&gt;Willcox, Mark&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Ophthalmic+%26+Physiological+Optics%22&quot;&gt;Ophthalmic &amp; Physiological Optics&lt;/searchLink&gt;. Mar2025, Vol. 45 Issue 2, p383-390. 8p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Contact+lenses%22&quot;&gt;Contact lenses&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Soft+contact+lenses%22&quot;&gt;Soft contact lenses&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Lipid+analysis%22&quot;&gt;Lipid analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Statistical+reliability%22&quot;&gt;Statistical reliability&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Membrane+lipids%22&quot;&gt;Membrane lipids&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Interferometers%22&quot;&gt;Interferometers&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To assess the repeatability of lipid layer thickness (LLT) measurement using the LipiView&#174; interferometer after daily disposable contact lens (CL) wear and correlation with ocular comfort in soft contact lens wearers. Methods: A prospective study was conducted over two consecutive months, wherein CL wearers (n = 20) wore either Somofilcon A or Verofilcon A daily disposable CLs in a crossover design, switching lenses after 1 month. The pre‐corneal tear film LLT was measured at the end of each month after CLs had been worn for at least 6 h. Using the LipiView&#174; interferometer, three measurements of the LLT (average, maximum and minimum) were recorded. Subjects&#39; symptoms were evaluated with the Contact Lens Dry Eye Questionnaire‐8 (CLDEQ‐8) and correlations sought between post‐lens pre‐corneal tear film LLT and symptoms. Results: The average, maximum and minimum intraclass correlation coefficients (ICC) of LLT measurements at baseline were 0.57, 0.39 and 0.66, respectively, indicating poor (ICC &lt; 0.4) to moderate (≥0.4, &lt;0.75) repeatability. Coefficients of repeatability (CR) were 20.4, 24.8 and 20.8, respectively. After daily disposable CL wear, the ICC values were 0.66, 0.72 and 0.63 (indicating moderate repeatability), with CR values of 25.7, 32.0 and 23.3, respectively. Although all the ICC values of the pre‐corneal LLT increased after daily disposable lens wear indicating improved repeatability, the CR values also increased, indicating larger spread of data. However, in both cases, these increases were not significantly different from baseline. There were no significant differences in pre‐corneal LLT between the two lens types and no significant correlation with comfort scores (baseline: r = −0.11, p = 0.67; Verofilcon A lenses: r = 0.19, p = 0.45; Somofilcon A lenses r = 0.13, p = 0.62) for either lens. Conclusions: The repeatability of average, maximum and minimum LLT measurements performed by LipiView remained stable during CL wear. There was no significant correlation between LLT and comfort scores. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Ophthalmic &amp; Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/opo.13445
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 383
    Subjects:
      – SubjectFull: Contact lenses
        Type: general
      – SubjectFull: Soft contact lenses
        Type: general
      – SubjectFull: Lipid analysis
        Type: general
      – SubjectFull: Statistical reliability
        Type: general
      – SubjectFull: Membrane lipids
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      – SubjectFull: Interferometers
        Type: general
    Titles:
      – TitleFull: Repeatability of lipid layer thickness using LipiView® following removal of contact lenses and its relationship to comfort.
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            NameFull: Kumar, Mukesh
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            NameFull: Dumpati, Srikanth
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              Text: Mar2025
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              Y: 2025
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