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Education moderates the association between motor involvement and executive status in ALS.

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Title: Education moderates the association between motor involvement and executive status in ALS.
Authors: Aiello, Edoardo Nicolò (AUTHOR), Poletti, Barbara (AUTHOR), Consonni, Monica (AUTHOR), Iazzolino, Barbara (AUTHOR), Torre, Silvia (AUTHOR), Faltracco, Veronica (AUTHOR), Telesca, Alessandra (AUTHOR), Palumbo, Francesca (AUTHOR), Curti, Beatrice (AUTHOR), De Luca, Giulia (AUTHOR), Bella, Eleonora Dalla (AUTHOR), Bersano, Enrica (AUTHOR), Riva, Nilo (AUTHOR), Verde, Federico (AUTHOR), Messina, Stefano (AUTHOR), Doretti, Alberto (AUTHOR), Maranzano, Alessio (AUTHOR), Morelli, Claudia (AUTHOR), Calvo, Andrea (AUTHOR), Silani, Vincenzo (AUTHOR)
Source: European Journal of Neurology. Jan2025, Vol. 32 Issue 1, p1-9. 9p.
Subjects: Executive function, Amyotrophic lateral sclerosis, Cognitive flexibility, Cognitive development, Cognitive ability, Moderation, Motor ability
Abstract: Background: This study aimed to determine whether educational attainment—a common proxy of cognitive reserve (CR)—influences the association between motor and cognitive/behavioural outcomes in a large cohort of ALS patients without dementia. Methods: N = 726 ALS patients without FTD were assessed for motor (ALSFRS‐R), cognitive (Edinburgh Cognitive and Behavioural ALS Screen, ECAS) and behavioural outcomes (ECAS‐Carer Interview, ECAS‐CI). CR was operationalized via educational attainment (in years). Moderation models were run on each subscale of the cognitive section of the ECAS and on the ECAS‐CI by addressing ALSFRS‐R as the predictor and education as the moderator. Results: Education was associated with both the ALSFRS‐R and all the cognitive subscales of the ECAS, while not with the ECAS‐CI. As to moderation models, a significant Education*ALSFRS‐R interaction was detected solely with regard to the ECAS‐Executive—with its simple slope‐based decomposition revealing that higher ALSFRS‐R scores were associated with higher scores on the ECAS‐Executive for patients with low (p < 0.001) and average (p = 0.007), while not high, levels of education. Discussion: Education seems to moderate the association between motor involvement and executive status in ALS patients without dementia, thus possibly exerting a protective role towards both motor function and cognition in this population. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Education moderates the association between motor involvement and executive status in ALS.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Aiello%2C+Edoardo+Nicol&#242;%22&quot;&gt;Aiello, Edoardo Nicol&#242;&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Poletti%2C+Barbara%22&quot;&gt;Poletti, Barbara&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Consonni%2C+Monica%22&quot;&gt;Consonni, Monica&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Iazzolino%2C+Barbara%22&quot;&gt;Iazzolino, Barbara&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Torre%2C+Silvia%22&quot;&gt;Torre, Silvia&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Faltracco%2C+Veronica%22&quot;&gt;Faltracco, Veronica&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Telesca%2C+Alessandra%22&quot;&gt;Telesca, Alessandra&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Palumbo%2C+Francesca%22&quot;&gt;Palumbo, Francesca&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Curti%2C+Beatrice%22&quot;&gt;Curti, Beatrice&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22De+Luca%2C+Giulia%22&quot;&gt;De Luca, Giulia&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bella%2C+Eleonora+Dalla%22&quot;&gt;Bella, Eleonora Dalla&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bersano%2C+Enrica%22&quot;&gt;Bersano, Enrica&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Riva%2C+Nilo%22&quot;&gt;Riva, Nilo&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Verde%2C+Federico%22&quot;&gt;Verde, Federico&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Messina%2C+Stefano%22&quot;&gt;Messina, Stefano&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Doretti%2C+Alberto%22&quot;&gt;Doretti, Alberto&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Maranzano%2C+Alessio%22&quot;&gt;Maranzano, Alessio&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Morelli%2C+Claudia%22&quot;&gt;Morelli, Claudia&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Calvo%2C+Andrea%22&quot;&gt;Calvo, Andrea&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Silani%2C+Vincenzo%22&quot;&gt;Silani, Vincenzo&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neurology%22&quot;&gt;European Journal of Neurology&lt;/searchLink&gt;. Jan2025, Vol. 32 Issue 1, p1-9. 9p.
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  Label: Abstract
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  Data: Background: This study aimed to determine whether educational attainment—a common proxy of cognitive reserve (CR)—influences the association between motor and cognitive/behavioural outcomes in a large cohort of ALS patients without dementia. Methods: N = 726 ALS patients without FTD were assessed for motor (ALSFRS‐R), cognitive (Edinburgh Cognitive and Behavioural ALS Screen, ECAS) and behavioural outcomes (ECAS‐Carer Interview, ECAS‐CI). CR was operationalized via educational attainment (in years). Moderation models were run on each subscale of the cognitive section of the ECAS and on the ECAS‐CI by addressing ALSFRS‐R as the predictor and education as the moderator. Results: Education was associated with both the ALSFRS‐R and all the cognitive subscales of the ECAS, while not with the ECAS‐CI. As to moderation models, a significant Education*ALSFRS‐R interaction was detected solely with regard to the ECAS‐Executive—with its simple slope‐based decomposition revealing that higher ALSFRS‐R scores were associated with higher scores on the ECAS‐Executive for patients with low (p &lt; 0.001) and average (p = 0.007), while not high, levels of education. Discussion: Education seems to moderate the association between motor involvement and executive status in ALS patients without dementia, thus possibly exerting a protective role towards both motor function and cognition in this population. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=184016594
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        Value: 10.1111/ene.70027
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        Text: English
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      – SubjectFull: Executive function
        Type: general
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      – SubjectFull: Cognitive flexibility
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