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Causes of hospitalization and mortality in persons with epilepsy: The EpiLink Bologna cohort, Italy.

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Title: Causes of hospitalization and mortality in persons with epilepsy: The EpiLink Bologna cohort, Italy.
Authors: Muccioli, Lorenzo (AUTHOR), Zenesini, Corrado (AUTHOR), Licchetta, Laura (AUTHOR), Belotti, Laura Maria Beatrice (AUTHOR), Vito, Lidia Di (AUTHOR), Ferri, Lorenzo (AUTHOR), Fiorillo, Domenico (AUTHOR), Mostacci, Barbara (AUTHOR), Pasini, Elena (AUTHOR), Riguzzi, Patrizia (AUTHOR), Soldà, Martina (AUTHOR), Taruffi, Lisa (AUTHOR), Volpi, Lilia (AUTHOR), Mason, Federico (AUTHOR), Nonino, Francesco (AUTHOR), Michelucci, Roberto (AUTHOR), Tinuper, Paolo (AUTHOR), Vignatelli, Luca (AUTHOR), Bisulli, Francesca (AUTHOR)
Source: European Journal of Neurology. Feb2025, Vol. 32 Issue 2, p1-10. 10p.
Subjects: Epilepsy, Mortality, Cohort analysis, Medical records, Anticonvulsants, Health policy, Hospital care, Risk assessment
Geographic Terms: Bologna (Italy), Italy
Abstract: Background: Epilepsy significantly impacts on morbidity and mortality. Understanding hospitalization and mortality risks in persons with epilepsy (PWE) is essential for improving healthcare strategies. We aimed to investigate the risk and causes of hospitalization and mortality in PWE compared to a matched general population cohort. Methods: The EpiLink Bologna historical cohort study analyzed adult PWE in the period 2018–2019. A general population control cohort was used for comparison. Clinical data were linked with health administrative data. PWE were grouped into persons with focal epilepsy, idiopathic generalized epilepsy, and developmental and/or epileptic encephalopathy (PDEE). The primary outcome was the hospitalization rate. Emergency department (ED) visit rate and the risk of death for any cause were also assessed. Results: The study included 1438 PWE and 14,096 controls. PWE had higher incidence rate ratio (IRR) for ED visit (IRR 1.26, 95% CI 1.20–1.32), hospital admission (IRR 2.05, 95% CI 1.83–2.29), and death (IRR 1.5, 95% CI 1.1–2.2) compared to control cohort. The highest hospitalization risk was in the PDEE group (IRR 4.70; 95% CI 3.28–6.74). The increased hospitalization rate among PWE was due to both their higher ED visit and elective hospital admission rates. PWE on polytherapy were at higher risk of hospitalization for inflammation of jaw, acid–base/electrolyte imbalances, chronic cerebrovascular disease, major traumas and infections. Conclusions: During a 2‐year‐period, PWE in Bologna had a doubled risk of hospitalization and 50% higher risk of death compared to a matched general population cohort. Hospitalization risks varied significantly by epilepsy type and antiseizure therapy. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Causes of hospitalization and mortality in persons with epilepsy: The EpiLink Bologna cohort, Italy.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Muccioli%2C+Lorenzo%22">Muccioli, Lorenzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zenesini%2C+Corrado%22">Zenesini, Corrado</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Licchetta%2C+Laura%22">Licchetta, Laura</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Belotti%2C+Laura+Maria+Beatrice%22">Belotti, Laura Maria Beatrice</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vito%2C+Lidia+Di%22">Vito, Lidia Di</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferri%2C+Lorenzo%22">Ferri, Lorenzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fiorillo%2C+Domenico%22">Fiorillo, Domenico</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mostacci%2C+Barbara%22">Mostacci, Barbara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pasini%2C+Elena%22">Pasini, Elena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riguzzi%2C+Patrizia%22">Riguzzi, Patrizia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Soldà%2C+Martina%22">Soldà, Martina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taruffi%2C+Lisa%22">Taruffi, Lisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Volpi%2C+Lilia%22">Volpi, Lilia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mason%2C+Federico%22">Mason, Federico</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nonino%2C+Francesco%22">Nonino, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Michelucci%2C+Roberto%22">Michelucci, Roberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tinuper%2C+Paolo%22">Tinuper, Paolo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vignatelli%2C+Luca%22">Vignatelli, Luca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bisulli%2C+Francesca%22">Bisulli, Francesca</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Feb2025, Vol. 32 Issue 2, p1-10. 10p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Mortality%22">Mortality</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+records%22">Medical records</searchLink><br /><searchLink fieldCode="DE" term="%22Anticonvulsants%22">Anticonvulsants</searchLink><br /><searchLink fieldCode="DE" term="%22Health+policy%22">Health policy</searchLink><br /><searchLink fieldCode="DE" term="%22Hospital+care%22">Hospital care</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Bologna+%28Italy%29%22">Bologna (Italy)</searchLink><br /><searchLink fieldCode="DE" term="%22Italy%22">Italy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Epilepsy significantly impacts on morbidity and mortality. Understanding hospitalization and mortality risks in persons with epilepsy (PWE) is essential for improving healthcare strategies. We aimed to investigate the risk and causes of hospitalization and mortality in PWE compared to a matched general population cohort. Methods: The EpiLink Bologna historical cohort study analyzed adult PWE in the period 2018–2019. A general population control cohort was used for comparison. Clinical data were linked with health administrative data. PWE were grouped into persons with focal epilepsy, idiopathic generalized epilepsy, and developmental and/or epileptic encephalopathy (PDEE). The primary outcome was the hospitalization rate. Emergency department (ED) visit rate and the risk of death for any cause were also assessed. Results: The study included 1438 PWE and 14,096 controls. PWE had higher incidence rate ratio (IRR) for ED visit (IRR 1.26, 95% CI 1.20–1.32), hospital admission (IRR 2.05, 95% CI 1.83–2.29), and death (IRR 1.5, 95% CI 1.1–2.2) compared to control cohort. The highest hospitalization risk was in the PDEE group (IRR 4.70; 95% CI 3.28–6.74). The increased hospitalization rate among PWE was due to both their higher ED visit and elective hospital admission rates. PWE on polytherapy were at higher risk of hospitalization for inflammation of jaw, acid–base/electrolyte imbalances, chronic cerebrovascular disease, major traumas and infections. Conclusions: During a 2‐year‐period, PWE in Bologna had a doubled risk of hospitalization and 50% higher risk of death compared to a matched general population cohort. Hospitalization risks varied significantly by epilepsy type and antiseizure therapy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=184019720
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        Value: 10.1111/ene.16576
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        Text: English
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      – SubjectFull: Bologna (Italy)
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