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Vitamin D levels and olfactory dysfunction in multiple sclerosis patients.

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Title: Vitamin D levels and olfactory dysfunction in multiple sclerosis patients.
Authors: Gao, Zidan (AUTHOR), Danzhen, Zhuoma (AUTHOR), Zhu, Junyu (AUTHOR), Li, Yao (AUTHOR), Xu, Zhu (AUTHOR), Chu, Lan (AUTHOR)
Source: International Journal of Neuroscience. Apr2025, Vol. 135 Issue 4, p420-427. 8p.
Subjects: Vitamin D, Olfactometry, Smell disorders, Multiple sclerosis, Rare diseases
Geographic Terms: China
Abstract: Objective: The objective was to explore the possible relationship between the serum vitamin D level and olfactory impairment in a population of multiple sclerosis (MS) patients in Guizhou, China. Methods: We included 25 patients with MS and 18 healthy controls (HCs) who were recruited from the Affiliated Hospital of Guizhou Medical University from February 2021 to September 2021. The University of Pennsylvania Smell Identification Test (UPSIT) was used to test the patients' sense of smell, and the level of serum 25-hydroxyethylene polyprotein D was measured. Results: Serum vitamin D levels and UPSIT scores were significantly different between the MS group and the control group (both p < 0.001). Moreover, a significant positive correlation emerged between vitamin D levels and UPSIT scores in MS patients (r = 0.537, p = 0.021). Conclusions: The serum vitamin D level may be involved in the regulation of olfactory dysfunction in MS patients in Guizhou, China. HIGHLIGHTS: Multiple sclerosis is a rare disease in China. Compared with that of healthy controls, the olfactory function of MS patients was severely impaired. Compared with healthy controls, MS patients had low vitamin D levels. A significant positive correlation emerged between vitamin D levels and UPSIT scores in MS patients. The vitamin D levels of MS patients may be associated with olfactory impairment, which may have implications for future mechanistic studies. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Vitamin D levels and olfactory dysfunction in multiple sclerosis patients.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gao%2C+Zidan%22&quot;&gt;Gao, Zidan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Danzhen%2C+Zhuoma%22&quot;&gt;Danzhen, Zhuoma&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhu%2C+Junyu%22&quot;&gt;Zhu, Junyu&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Yao%22&quot;&gt;Li, Yao&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xu%2C+Zhu%22&quot;&gt;Xu, Zhu&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chu%2C+Lan%22&quot;&gt;Chu, Lan&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Neuroscience%22&quot;&gt;International Journal of Neuroscience&lt;/searchLink&gt;. Apr2025, Vol. 135 Issue 4, p420-427. 8p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Vitamin+D%22&quot;&gt;Vitamin D&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Olfactometry%22&quot;&gt;Olfactometry&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Smell+disorders%22&quot;&gt;Smell disorders&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Multiple+sclerosis%22&quot;&gt;Multiple sclerosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Rare+diseases%22&quot;&gt;Rare diseases&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22China%22&quot;&gt;China&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
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  Data: Objective: The objective was to explore the possible relationship between the serum vitamin D level and olfactory impairment in a population of multiple sclerosis (MS) patients in Guizhou, China. Methods: We included 25 patients with MS and 18 healthy controls (HCs) who were recruited from the Affiliated Hospital of Guizhou Medical University from February 2021 to September 2021. The University of Pennsylvania Smell Identification Test (UPSIT) was used to test the patients&#39; sense of smell, and the level of serum 25-hydroxyethylene polyprotein D was measured. Results: Serum vitamin D levels and UPSIT scores were significantly different between the MS group and the control group (both p &lt; 0.001). Moreover, a significant positive correlation emerged between vitamin D levels and UPSIT scores in MS patients (r = 0.537, p = 0.021). Conclusions: The serum vitamin D level may be involved in the regulation of olfactory dysfunction in MS patients in Guizhou, China. HIGHLIGHTS: Multiple sclerosis is a rare disease in China. Compared with that of healthy controls, the olfactory function of MS patients was severely impaired. Compared with healthy controls, MS patients had low vitamin D levels. A significant positive correlation emerged between vitamin D levels and UPSIT scores in MS patients. The vitamin D levels of MS patients may be associated with olfactory impairment, which may have implications for future mechanistic studies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of International Journal of Neuroscience is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00207454.2024.2304081
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 420
    Subjects:
      – SubjectFull: Vitamin D
        Type: general
      – SubjectFull: Olfactometry
        Type: general
      – SubjectFull: Smell disorders
        Type: general
      – SubjectFull: Multiple sclerosis
        Type: general
      – SubjectFull: Rare diseases
        Type: general
      – SubjectFull: China
        Type: general
    Titles:
      – TitleFull: Vitamin D levels and olfactory dysfunction in multiple sclerosis patients.
        Type: main
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          Name:
            NameFull: Gao, Zidan
      – PersonEntity:
          Name:
            NameFull: Danzhen, Zhuoma
      – PersonEntity:
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            NameFull: Zhu, Junyu
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            NameFull: Li, Yao
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            NameFull: Xu, Zhu
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            NameFull: Chu, Lan
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          Dates:
            – D: 01
              M: 04
              Text: Apr2025
              Type: published
              Y: 2025
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              Value: 00207454
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              Value: 135
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: International Journal of Neuroscience
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