Resting-state functional connectivity correlates of brain structural aging in schizophrenia.
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| Title: | Resting-state functional connectivity correlates of brain structural aging in schizophrenia. |
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| Authors: | Panikratova, Yana R. (AUTHOR), Tomyshev, Alexander S. (AUTHOR), Abdullina, Ekaterina G. (AUTHOR), Rodionov, Georgiy I. (AUTHOR), Arkhipov, Andrey Yu. (AUTHOR), Tikhonov, Denis V. (AUTHOR), Bozhko, Olga V. (AUTHOR), Kaleda, Vasily G. (AUTHOR), Strelets, Valeria B. (AUTHOR), Lebedeva, Irina S. (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Apr2025, Vol. 275 Issue 3, p755-766. 12p. |
| Subjects: | Schizophrenia, Functional connectivity, Frontal lobe, Functional magnetic resonance imaging, Cognition disorders, Temporal lobe, Brain imaging |
| Abstract: | A large body of research has shown that schizophrenia patients demonstrate increased brain structural aging. Although this process may be coupled with aberrant changes in intrinsic functional architecture of the brain, they remain understudied. We hypothesized that there are brain regions whose whole-brain functional connectivity at rest is differently associated with brain structural aging in schizophrenia patients compared to healthy controls. Eighty-four male schizophrenia patients and eighty-six male healthy controls underwent structural MRI and resting-state fMRI. The brain-predicted age difference (b-PAD) was a measure of brain structural aging. Resting-state fMRI was applied to obtain global correlation (GCOR) maps comprising voxelwise values of the strength and sign of functional connectivity of a given voxel with the rest of the brain. Schizophrenia patients had higher b-PAD compared to controls (mean between-group difference + 2.9 years). Greater b-PAD in schizophrenia patients, compared to controls, was associated with lower whole-brain functional connectivity of a region in frontal orbital cortex, inferior frontal gyrus, Heschl's Gyrus, plana temporale and polare, insula, and opercular cortices of the right hemisphere (rFTI). According to post hoc seed-based correlation analysis, decrease of functional connectivity with the posterior cingulate gyrus, left superior temporal cortices, as well as right angular gyrus/superior lateral occipital cortex has mainly driven the results. Lower functional connectivity of the rFTI was related to worse verbal working memory and language production. Our findings demonstrate that well-established frontotemporal functional abnormalities in schizophrenia are related to increased brain structural aging. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 184037803 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Resting-state functional connectivity correlates of brain structural aging in schizophrenia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Panikratova%2C+Yana+R%2E%22">Panikratova, Yana R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tomyshev%2C+Alexander+S%2E%22">Tomyshev, Alexander S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abdullina%2C+Ekaterina+G%2E%22">Abdullina, Ekaterina G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodionov%2C+Georgiy+I%2E%22">Rodionov, Georgiy I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arkhipov%2C+Andrey+Yu%2E%22">Arkhipov, Andrey Yu.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tikhonov%2C+Denis+V%2E%22">Tikhonov, Denis V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bozhko%2C+Olga+V%2E%22">Bozhko, Olga V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaleda%2C+Vasily+G%2E%22">Kaleda, Vasily G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Strelets%2C+Valeria+B%2E%22">Strelets, Valeria B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lebedeva%2C+Irina+S%2E%22">Lebedeva, Irina S.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Apr2025, Vol. 275 Issue 3, p755-766. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+connectivity%22">Functional connectivity</searchLink><br /><searchLink fieldCode="DE" term="%22Frontal+lobe%22">Frontal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Temporal+lobe%22">Temporal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: A large body of research has shown that schizophrenia patients demonstrate increased brain structural aging. Although this process may be coupled with aberrant changes in intrinsic functional architecture of the brain, they remain understudied. We hypothesized that there are brain regions whose whole-brain functional connectivity at rest is differently associated with brain structural aging in schizophrenia patients compared to healthy controls. Eighty-four male schizophrenia patients and eighty-six male healthy controls underwent structural MRI and resting-state fMRI. The brain-predicted age difference (b-PAD) was a measure of brain structural aging. Resting-state fMRI was applied to obtain global correlation (GCOR) maps comprising voxelwise values of the strength and sign of functional connectivity of a given voxel with the rest of the brain. Schizophrenia patients had higher b-PAD compared to controls (mean between-group difference + 2.9 years). Greater b-PAD in schizophrenia patients, compared to controls, was associated with lower whole-brain functional connectivity of a region in frontal orbital cortex, inferior frontal gyrus, Heschl's Gyrus, plana temporale and polare, insula, and opercular cortices of the right hemisphere (rFTI). According to post hoc seed-based correlation analysis, decrease of functional connectivity with the posterior cingulate gyrus, left superior temporal cortices, as well as right angular gyrus/superior lateral occipital cortex has mainly driven the results. Lower functional connectivity of the rFTI was related to worse verbal working memory and language production. Our findings demonstrate that well-established frontotemporal functional abnormalities in schizophrenia are related to increased brain structural aging. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-024-01837-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 755 Subjects: – SubjectFull: Schizophrenia Type: general – SubjectFull: Functional connectivity Type: general – SubjectFull: Frontal lobe Type: general – SubjectFull: Functional magnetic resonance imaging Type: general – SubjectFull: Cognition disorders Type: general – SubjectFull: Temporal lobe Type: general – SubjectFull: Brain imaging Type: general Titles: – TitleFull: Resting-state functional connectivity correlates of brain structural aging in schizophrenia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Panikratova, Yana R. – PersonEntity: Name: NameFull: Tomyshev, Alexander S. – PersonEntity: Name: NameFull: Abdullina, Ekaterina G. – PersonEntity: Name: NameFull: Rodionov, Georgiy I. – PersonEntity: Name: NameFull: Arkhipov, Andrey Yu. – PersonEntity: Name: NameFull: Tikhonov, Denis V. – PersonEntity: Name: NameFull: Bozhko, Olga V. – PersonEntity: Name: NameFull: Kaleda, Vasily G. – PersonEntity: Name: NameFull: Strelets, Valeria B. – PersonEntity: Name: NameFull: Lebedeva, Irina S. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 275 – Type: issue Value: 3 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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