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Unilateral and Bilateral Subthalamic Deep Brain Stimulation Differently Favour Apathy in Parkinson's Disease.

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Title: Unilateral and Bilateral Subthalamic Deep Brain Stimulation Differently Favour Apathy in Parkinson's Disease.
Authors: Vachez, Yvan M. (AUTHOR), Bahout, Marie (AUTHOR), Magnard, Robin (AUTHOR), David, Pierre‐Maxime (AUTHOR), Carcenac, Carole (AUTHOR), Wilt, Mylène (AUTHOR), Robert, Gabriel (AUTHOR), Savasta, Marc (AUTHOR), Carnicella, Sebastien (AUTHOR), Vérin, Marc (AUTHOR), Boulet, Sabrina (AUTHOR)
Source: European Journal of Neuroscience. Feb2025, Vol. 61 Issue 4, p1-12. 12p.
Subjects: Apathy, Parkinson's disease, Incentive (Psychology), Neurobehavioral disorders, Deep brain stimulation, Subthalamic nucleus
Abstract: The link between subthalamic nucleus deep brain stimulation (STN‐DBS) and apathy in patients with Parkinson's disease (PD) remains a controversial topic. The literature is mixed and the most supported explanation is the reduction of dopaminergic treatment. Yet a body of clinical and experimental evidences suggest that STN‐DBS itself can also promote apathy in certain patients. However, the parameters accounting for apathy heterogeneity in stimulated patients along with the mechanisms underlying apathy induced by STN‐DBS remain to be investigated. Whether bilateral and unilateral STN‐DBS have the same influence on apathy is for instance unknown. We previously and separately showed in patients and rodents that bilateral STN‐DBS can promote apathy per se. Here, we compare the effect of bilateral versus unilateral STN‐DBS both in patients and in rodents. We conducted a clinical follow‐up of patients with Parkinson's disease undergoing unilateral or bilateral STN‐DBS and assessing apathy 3 months before and after STN‐DBS. In parallel, we applied chronic and uninterrupted unilateral or bilateral DBS in rodents and extract longitudinal motivational changes with a battery of behavioural tests. While bilateral STN‐DBS promotes apathy in patients and induces a loss of motivation in rodents, we found that unilateral STN‐DBS did not exert such an effect both in patients and in rats. These data show that bilateral but not unilateral STN‐DBS promotes apathy. This not only substantiate the induction of neuropsychiatric effects by STN‐DBS but also suggest that this might be circumvented if STN‐DBS is applied unilaterally instead of bilaterally. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Unilateral and Bilateral Subthalamic Deep Brain Stimulation Differently Favour Apathy in Parkinson's Disease.
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  Data: <searchLink fieldCode="AR" term="%22Vachez%2C+Yvan M%2E%22">Vachez, Yvan M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bahout%2C+Marie%22">Bahout, Marie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Magnard%2C+Robin%22">Magnard, Robin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22David%2C+Pierre‐Maxime%22">David, Pierre‐Maxime</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carcenac%2C+Carole%22">Carcenac, Carole</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wilt%2C+Mylène%22">Wilt, Mylène</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Robert%2C+Gabriel%22">Robert, Gabriel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Savasta%2C+Marc%22">Savasta, Marc</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carnicella%2C+Sebastien%22">Carnicella, Sebastien</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vérin%2C+Marc%22">Vérin, Marc</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Boulet%2C+Sabrina%22">Boulet, Sabrina</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Feb2025, Vol. 61 Issue 4, p1-12. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Apathy%22">Apathy</searchLink><br /><searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Incentive+%28Psychology%29%22">Incentive (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Neurobehavioral+disorders%22">Neurobehavioral disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Deep+brain+stimulation%22">Deep brain stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Subthalamic+nucleus%22">Subthalamic nucleus</searchLink>
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  Label: Abstract
  Group: Ab
  Data: The link between subthalamic nucleus deep brain stimulation (STN‐DBS) and apathy in patients with Parkinson's disease (PD) remains a controversial topic. The literature is mixed and the most supported explanation is the reduction of dopaminergic treatment. Yet a body of clinical and experimental evidences suggest that STN‐DBS itself can also promote apathy in certain patients. However, the parameters accounting for apathy heterogeneity in stimulated patients along with the mechanisms underlying apathy induced by STN‐DBS remain to be investigated. Whether bilateral and unilateral STN‐DBS have the same influence on apathy is for instance unknown. We previously and separately showed in patients and rodents that bilateral STN‐DBS can promote apathy per se. Here, we compare the effect of bilateral versus unilateral STN‐DBS both in patients and in rodents. We conducted a clinical follow‐up of patients with Parkinson's disease undergoing unilateral or bilateral STN‐DBS and assessing apathy 3 months before and after STN‐DBS. In parallel, we applied chronic and uninterrupted unilateral or bilateral DBS in rodents and extract longitudinal motivational changes with a battery of behavioural tests. While bilateral STN‐DBS promotes apathy in patients and induces a loss of motivation in rodents, we found that unilateral STN‐DBS did not exert such an effect both in patients and in rats. These data show that bilateral but not unilateral STN‐DBS promotes apathy. This not only substantiate the induction of neuropsychiatric effects by STN‐DBS but also suggest that this might be circumvented if STN‐DBS is applied unilaterally instead of bilaterally. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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      – SubjectFull: Apathy
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      – SubjectFull: Subthalamic nucleus
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      – TitleFull: Unilateral and Bilateral Subthalamic Deep Brain Stimulation Differently Favour Apathy in Parkinson's Disease.
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              Text: Feb2025
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