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Association of early general anesthesia with outcome in adults with status epilepticus: A propensity‐matched observational study.

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Title: Association of early general anesthesia with outcome in adults with status epilepticus: A propensity‐matched observational study.
Authors: Beuchat, Isabelle (AUTHOR), Novy, Jan (AUTHOR), Alvarez, Vincent (AUTHOR), Rosenow, Felix (AUTHOR), Kellinghaus, Christoph (AUTHOR), Rüegg, Stephan (AUTHOR), Tilz, Christian (AUTHOR), Trinka, Eugen (AUTHOR), Unterberger, Iris (AUTHOR), Uzelac, Zeljko (AUTHOR), Strzelczyk, Adam (AUTHOR), Rossetti, Andrea O. (AUTHOR)
Source: Epilepsia (Series 4). Jan2025, Vol. 66 Issue 1, pe7-e13. 7p.
Subjects: General anesthesia, Status epilepticus, Mortality, Treatment effectiveness, Length of stay in hospitals, Health outcome assessment, Early medical intervention, Propensity score matching
Abstract: General anesthesia (GA) earlier than recommended (as first‐ or second‐line treatment) was recently described to improve status epilepticus (SE) outcome. We aimed to assess the impact of early GA on outcome in matched groups. Data from a multicenter, prospective cohort of 1179 SE episodes in 1049 adults were retrospectively analyzed. Incident SE episodes were categorized as "early anesthesia" (eGA; GA as first‐ or second‐line treatment) or "non‐early anesthesia" (neGA; GA after second‐line treatment or not at all). Using propensity score matching, eGA episodes were paired 1:4 with neGA episodes. We assessed survival, functional outcomes at discharge (good: modified Rankin Scale = 0–2 or no worsening), SE cessation rate, SE duration, and hospital stay. Among 1049 SE episodes, 55 (5.2%) received eGA, and 994 constituted the neGA group; 220 represented the matched controls. Patients receiving eGA were younger (median = 63, interquartile range [IQR] = 56–76 vs. median = 70, IQR = 54–80 years, p =.004), had deeper consciousness impairment (80% vs. 40% stuporous/comatose, p <.001), and had more severe SE forms (89% vs. 54% generalized convulsive SE/nonconvulsive SE in coma, p <.001). Mortality, functional outcome, SE cessation rate, and duration of SE and hospital stay were similar between the eGA group and matched controls. We conclude that early anesthesia for SE treatment did not influence prognosis. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Association of early general anesthesia with outcome in adults with status epilepticus: A propensity‐matched observational study.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Beuchat%2C+Isabelle%22&quot;&gt;Beuchat, Isabelle&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Novy%2C+Jan%22&quot;&gt;Novy, Jan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Alvarez%2C+Vincent%22&quot;&gt;Alvarez, Vincent&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rosenow%2C+Felix%22&quot;&gt;Rosenow, Felix&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kellinghaus%2C+Christoph%22&quot;&gt;Kellinghaus, Christoph&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22R&#252;egg%2C+Stephan%22&quot;&gt;R&#252;egg, Stephan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tilz%2C+Christian%22&quot;&gt;Tilz, Christian&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Trinka%2C+Eugen%22&quot;&gt;Trinka, Eugen&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Unterberger%2C+Iris%22&quot;&gt;Unterberger, Iris&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Uzelac%2C+Zeljko%22&quot;&gt;Uzelac, Zeljko&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Strzelczyk%2C+Adam%22&quot;&gt;Strzelczyk, Adam&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rossetti%2C+Andrea+O%2E%22&quot;&gt;Rossetti, Andrea O.&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Epilepsia+%28Series+4%29%22&quot;&gt;Epilepsia (Series 4)&lt;/searchLink&gt;. Jan2025, Vol. 66 Issue 1, pe7-e13. 7p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22General+anesthesia%22&quot;&gt;General anesthesia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Status+epilepticus%22&quot;&gt;Status epilepticus&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mortality%22&quot;&gt;Mortality&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Treatment+effectiveness%22&quot;&gt;Treatment effectiveness&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Length+of+stay+in+hospitals%22&quot;&gt;Length of stay in hospitals&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Health+outcome+assessment%22&quot;&gt;Health outcome assessment&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Early+medical+intervention%22&quot;&gt;Early medical intervention&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Propensity+score+matching%22&quot;&gt;Propensity score matching&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: General anesthesia (GA) earlier than recommended (as first‐ or second‐line treatment) was recently described to improve status epilepticus (SE) outcome. We aimed to assess the impact of early GA on outcome in matched groups. Data from a multicenter, prospective cohort of 1179 SE episodes in 1049 adults were retrospectively analyzed. Incident SE episodes were categorized as &quot;early anesthesia&quot; (eGA; GA as first‐ or second‐line treatment) or &quot;non‐early anesthesia&quot; (neGA; GA after second‐line treatment or not at all). Using propensity score matching, eGA episodes were paired 1:4 with neGA episodes. We assessed survival, functional outcomes at discharge (good: modified Rankin Scale = 0–2 or no worsening), SE cessation rate, SE duration, and hospital stay. Among 1049 SE episodes, 55 (5.2%) received eGA, and 994 constituted the neGA group; 220 represented the matched controls. Patients receiving eGA were younger (median = 63, interquartile range [IQR] = 56–76 vs. median = 70, IQR = 54–80 years, p =.004), had deeper consciousness impairment (80% vs. 40% stuporous/comatose, p &lt;.001), and had more severe SE forms (89% vs. 54% generalized convulsive SE/nonconvulsive SE in coma, p &lt;.001). Mortality, functional outcome, SE cessation rate, and duration of SE and hospital stay were similar between the eGA group and matched controls. We conclude that early anesthesia for SE treatment did not influence prognosis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/epi.18203
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      – Code: eng
        Text: English
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        PageCount: 7
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    Subjects:
      – SubjectFull: General anesthesia
        Type: general
      – SubjectFull: Status epilepticus
        Type: general
      – SubjectFull: Mortality
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Length of stay in hospitals
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      – SubjectFull: Health outcome assessment
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      – SubjectFull: Early medical intervention
        Type: general
      – SubjectFull: Propensity score matching
        Type: general
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      – TitleFull: Association of early general anesthesia with outcome in adults with status epilepticus: A propensity‐matched observational study.
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              Text: Jan2025
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