Sex‐Related Differences in Outcomes of Endovascular Treatment in Large Vessel Occlusion Stroke—Analyses From the German Stroke Registry‐Endovascular Treatment.
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| Title: | Sex‐Related Differences in Outcomes of Endovascular Treatment in Large Vessel Occlusion Stroke—Analyses From the German Stroke Registry‐Endovascular Treatment. |
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| Authors: | Single, Constanze (AUTHOR), Mengel, Annerose (AUTHOR), Laichinger, Kornelia (AUTHOR), Sartor‐Pfeiffer, Jennifer (AUTHOR), Selo, Nadja (AUTHOR), Hennersdorf, Florian (AUTHOR), Bender, Benjamin (AUTHOR), Deb‐Chatterji, Milani (AUTHOR), Thomalla, Götz (AUTHOR), Mbroh, Joshua (AUTHOR), Poli, Sven (AUTHOR), Ziemann, Ulf (AUTHOR), Ernemann, Ulrike (AUTHOR), Feil, Katharina (AUTHOR) |
| Source: | European Journal of Neurology. Mar2025, Vol. 32 Issue 3, p1-13. 13p. |
| Subjects: | Ischemic stroke, Thrombectomy, Gender inequality, Stroke, Arterial occlusions, Endovascular surgery |
| Abstract: | Background: Sex‐related differences in acute ischemic stroke may affect outcomes, yet evidence remains inconsistent. This large‐scale study investigated sex‐related differences in clinical presentation, peri‐interventional parameters, and outcomes after endovascular thrombectomy (EVT) for large vessel occlusion (LVO) using data from the German Stroke Registry—Endovascular Treatment (GSR‐ET). Methods: We analyzed 11.896 EVT patients (52.2% female) from the GSR‐ET (June 2015–December 2021) comparing clinical characteristics, treatment details, and outcomes by sex. Two propensity score matchings (PSM) were applied: (1) logistic regression model with a caliper width of 0.1 on age, pre‐stroke modified Rankin Scale (pmRS), and National Institutes of Health Stroke Scale at admission, and (2) 1:1 nearest neighbor matching with a caliper of 0.01. Primary outcomes were good (mRS 0–2) and excellent (mRS 0–1) outcomes at discharge and 90‐day follow‐up. Results: Women were older (76.3 ± 12.7 vs. 70.2 ± 12.9 years, p < 0.001) and had higher pre‐stroke disability (median pmRS 0 (0, 2) vs. 0 (0, 1), p < 0.001). Cardioembolic strokes were more frequent in women, even after PSM. Despite this, women had better odds of achieving good outcomes at discharge (adjusted OR 1.20, 95% CI 1.04–1.38, p = 0.013), but not at follow‐up (OR 0.91, 95% CI 0.78–1.05, p = 0.193). Both PSM analyses confirmed these findings. Conclusions: While women demonstrated better short‐term functional outcomes after EVT, these benefits diminished in follow‐up. The persistence of cardioembolic stroke in women suggests potential sex‐specific mechanisms. Understanding and addressing sex‐related differences in stroke is essential to optimize acute stroke care and improve outcomes. Future studies should explore biological and socio‐economic factors influencing sex‐related differences. Trial Registration: ClinicalTrials.gov identifier: NCT03356392 [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 184044639 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Sex‐Related Differences in Outcomes of Endovascular Treatment in Large Vessel Occlusion Stroke—Analyses From the German Stroke Registry‐Endovascular Treatment. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Single%2C+Constanze%22">Single, Constanze</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mengel%2C+Annerose%22">Mengel, Annerose</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Laichinger%2C+Kornelia%22">Laichinger, Kornelia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sartor‐Pfeiffer%2C+Jennifer%22">Sartor‐Pfeiffer, Jennifer</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Selo%2C+Nadja%22">Selo, Nadja</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hennersdorf%2C+Florian%22">Hennersdorf, Florian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bender%2C+Benjamin%22">Bender, Benjamin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deb‐Chatterji%2C+Milani%22">Deb‐Chatterji, Milani</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thomalla%2C+Götz%22">Thomalla, Götz</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mbroh%2C+Joshua%22">Mbroh, Joshua</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poli%2C+Sven%22">Poli, Sven</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ziemann%2C+Ulf%22">Ziemann, Ulf</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ernemann%2C+Ulrike%22">Ernemann, Ulrike</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Feil%2C+Katharina%22">Feil, Katharina</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Mar2025, Vol. 32 Issue 3, p1-13. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Ischemic+stroke%22">Ischemic stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Thrombectomy%22">Thrombectomy</searchLink><br /><searchLink fieldCode="DE" term="%22Gender+inequality%22">Gender inequality</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke%22">Stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Arterial+occlusions%22">Arterial occlusions</searchLink><br /><searchLink fieldCode="DE" term="%22Endovascular+surgery%22">Endovascular surgery</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Sex‐related differences in acute ischemic stroke may affect outcomes, yet evidence remains inconsistent. This large‐scale study investigated sex‐related differences in clinical presentation, peri‐interventional parameters, and outcomes after endovascular thrombectomy (EVT) for large vessel occlusion (LVO) using data from the German Stroke Registry—Endovascular Treatment (GSR‐ET). Methods: We analyzed 11.896 EVT patients (52.2% female) from the GSR‐ET (June 2015–December 2021) comparing clinical characteristics, treatment details, and outcomes by sex. Two propensity score matchings (PSM) were applied: (1) logistic regression model with a caliper width of 0.1 on age, pre‐stroke modified Rankin Scale (pmRS), and National Institutes of Health Stroke Scale at admission, and (2) 1:1 nearest neighbor matching with a caliper of 0.01. Primary outcomes were good (mRS 0–2) and excellent (mRS 0–1) outcomes at discharge and 90‐day follow‐up. Results: Women were older (76.3 ± 12.7 vs. 70.2 ± 12.9 years, p < 0.001) and had higher pre‐stroke disability (median pmRS 0 (0, 2) vs. 0 (0, 1), p < 0.001). Cardioembolic strokes were more frequent in women, even after PSM. Despite this, women had better odds of achieving good outcomes at discharge (adjusted OR 1.20, 95% CI 1.04–1.38, p = 0.013), but not at follow‐up (OR 0.91, 95% CI 0.78–1.05, p = 0.193). Both PSM analyses confirmed these findings. Conclusions: While women demonstrated better short‐term functional outcomes after EVT, these benefits diminished in follow‐up. The persistence of cardioembolic stroke in women suggests potential sex‐specific mechanisms. Understanding and addressing sex‐related differences in stroke is essential to optimize acute stroke care and improve outcomes. Future studies should explore biological and socio‐economic factors influencing sex‐related differences. Trial Registration: ClinicalTrials.gov identifier: NCT03356392 [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ene.70092 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1 Subjects: – SubjectFull: Ischemic stroke Type: general – SubjectFull: Thrombectomy Type: general – SubjectFull: Gender inequality Type: general – SubjectFull: Stroke Type: general – SubjectFull: Arterial occlusions Type: general – SubjectFull: Endovascular surgery Type: general Titles: – TitleFull: Sex‐Related Differences in Outcomes of Endovascular Treatment in Large Vessel Occlusion Stroke—Analyses From the German Stroke Registry‐Endovascular Treatment. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Single, Constanze – PersonEntity: Name: NameFull: Mengel, Annerose – PersonEntity: Name: NameFull: Laichinger, Kornelia – PersonEntity: Name: NameFull: Sartor‐Pfeiffer, Jennifer – PersonEntity: Name: NameFull: Selo, Nadja – PersonEntity: Name: NameFull: Hennersdorf, Florian – PersonEntity: Name: NameFull: Bender, Benjamin – PersonEntity: Name: NameFull: Deb‐Chatterji, Milani – PersonEntity: Name: NameFull: Thomalla, Götz – PersonEntity: Name: NameFull: Mbroh, Joshua – PersonEntity: Name: NameFull: Poli, Sven – PersonEntity: Name: NameFull: Ziemann, Ulf – PersonEntity: Name: NameFull: Ernemann, Ulrike – PersonEntity: Name: NameFull: Feil, Katharina IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 32 – Type: issue Value: 3 Titles: – TitleFull: European Journal of Neurology Type: main |
| ResultId | 1 |
