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Diagnostic, survival, and tumor control outcomes of parapharyngeal space liposarcoma: a systematic review.

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Title: Diagnostic, survival, and tumor control outcomes of parapharyngeal space liposarcoma: a systematic review.
Authors: Vasudevan, Srivatsa Surya (AUTHOR), Candelo, Estephania (AUTHOR), Kandrikar, Tiba Yamin (AUTHOR), Janus, Jeffrey R. (AUTHOR)
Source: Acta Oto-Laryngologica. Apr2025, Vol. 145 Issue 4, p348-354. 7p.
Subjects: Head & neck cancer diagnosis, Cytology, Cancer relapse, Treatment effectiveness, Preoperative care, Descriptive statistics, Liposarcoma, Systematic reviews, MEDLINE, Kaplan-Meier estimator, Needle biopsy, Online information services, Progression-free survival, Survival analysis (Biometry), Overall survival
Abstract (English): Background: Parapharyngeal space liposarcomas (PPS-LS) are rare tumors often associated with a moderate-to-poor prognosis. Objectives: This study aims to assess tumor control and survival outcomes across the various subtypes of PPS-LS. Material and methods: We conducted a systematic review of cases using PubMed, OVID, Scopus, Web of Science, ScienceDirect, and EBSCO from inception to October 2024. Given the data on individual patient follow-up, Kaplan–Meier survival analysis was utilized to calculate disease-free survival (DFS) and disease-specific survival (DSS). Results: Out of 303 articles, 10 studies with 11 patients (72.7% male) met the inclusion criteria, with a mean age of 51.3 years (range: 12–77.5). Preoperative fine needle aspiration cytology was conducted in 45.4%, with 80% yielding inconclusive results. The 2-year and 5-year DFS rates for PPS-LS were 64% and 50%, respectively, while the 2-year DSS rate was 84%. Tumor recurrence occurred in 36.3% of patients, with an average of 2.5 recurrences per patient, specifically the myxoid subtype of PPS-LS. Conclusion: This systematic review highlights the varied prognostic outcomes of PPS-LS and its subtypes, emphasizing the need for vigilant surveillance to improve DFS and reduce recurrence rates. Significance: This provides surgeons with critical insights into probable prognostic outcomes when dealing with specific subtypes of PPS-LS. [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 咽旁间隙脂肪肉瘤 (PPS-LS) 是一种罕见肿瘤, 通常预后中等至不良。 本研究旨在评估 PPS-LS 各种亚型的肿瘤控制和生存结果。 我们使用 PubMed、OVID、Scopus、Web of Science、ScienceDirect 和 EBSCO 对从开始到 2024 年 10 月的病例进行了系统回顾。根据个体患者随访数据, 使用 Kaplan-Meier 生存分析计算无病生存期 (DFS) 和疾病特异性生存期 (DSS)。 在 303 篇文章中, 10 项研究(11 名患者, 72.7% 为男性)符合纳入标准, 平均年龄为 51.3 岁(范围: 12-77.5 岁)。 45.4% 的患者进行了术前细针穿刺细胞学检查, 其中 80% 的结果不确定。PPS-LS 的 两 年和 五年 DFS 率分别为 64% 和 50%, 而 两年 DSS 率为 84%。36.3% 的患者发生肿瘤复发, 平均每例患者复发 2.5 次, 尤其是 PPS-LS 的粘液样亚型。 本系统评价突显了 PPS-LS 及其亚型的不同预后结果, 强调需要进行警觉监测以改善 DFS 并降低复发率。 本研究为外科医生在处理 PPS-LS 的特定亚型时提供了对可能的预后结果的关键性理解。 [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Diagnostic, survival, and tumor control outcomes of parapharyngeal space liposarcoma: a systematic review.
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  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Vasudevan%2C+Srivatsa+Surya%22">Vasudevan, Srivatsa Surya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Candelo%2C+Estephania%22">Candelo, Estephania</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kandrikar%2C+Tiba+Yamin%22">Kandrikar, Tiba Yamin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Janus%2C+Jeffrey+R%2E%22">Janus, Jeffrey R.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Apr2025, Vol. 145 Issue 4, p348-354. 7p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Head+%26+neck+cancer+diagnosis%22">Head & neck cancer diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Cytology%22">Cytology</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+relapse%22">Cancer relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Preoperative+care%22">Preoperative care</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Liposarcoma%22">Liposarcoma</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink><br /><searchLink fieldCode="DE" term="%22MEDLINE%22">MEDLINE</searchLink><br /><searchLink fieldCode="DE" term="%22Kaplan-Meier+estimator%22">Kaplan-Meier estimator</searchLink><br /><searchLink fieldCode="DE" term="%22Needle+biopsy%22">Needle biopsy</searchLink><br /><searchLink fieldCode="DE" term="%22Online+information+services%22">Online information services</searchLink><br /><searchLink fieldCode="DE" term="%22Progression-free+survival%22">Progression-free survival</searchLink><br /><searchLink fieldCode="DE" term="%22Survival+analysis+%28Biometry%29%22">Survival analysis (Biometry)</searchLink><br /><searchLink fieldCode="DE" term="%22Overall+survival%22">Overall survival</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Background: Parapharyngeal space liposarcomas (PPS-LS) are rare tumors often associated with a moderate-to-poor prognosis. Objectives: This study aims to assess tumor control and survival outcomes across the various subtypes of PPS-LS. Material and methods: We conducted a systematic review of cases using PubMed, OVID, Scopus, Web of Science, ScienceDirect, and EBSCO from inception to October 2024. Given the data on individual patient follow-up, Kaplan–Meier survival analysis was utilized to calculate disease-free survival (DFS) and disease-specific survival (DSS). Results: Out of 303 articles, 10 studies with 11 patients (72.7% male) met the inclusion criteria, with a mean age of 51.3 years (range: 12–77.5). Preoperative fine needle aspiration cytology was conducted in 45.4%, with 80% yielding inconclusive results. The 2-year and 5-year DFS rates for PPS-LS were 64% and 50%, respectively, while the 2-year DSS rate was 84%. Tumor recurrence occurred in 36.3% of patients, with an average of 2.5 recurrences per patient, specifically the myxoid subtype of PPS-LS. Conclusion: This systematic review highlights the varied prognostic outcomes of PPS-LS and its subtypes, emphasizing the need for vigilant surveillance to improve DFS and reduce recurrence rates. Significance: This provides surgeons with critical insights into probable prognostic outcomes when dealing with specific subtypes of PPS-LS. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Chinese)
  Group: Ab
  Data: 咽旁间隙脂肪肉瘤 (PPS-LS) 是一种罕见肿瘤, 通常预后中等至不良。 本研究旨在评估 PPS-LS 各种亚型的肿瘤控制和生存结果。 我们使用 PubMed、OVID、Scopus、Web of Science、ScienceDirect 和 EBSCO 对从开始到 2024 年 10 月的病例进行了系统回顾。根据个体患者随访数据, 使用 Kaplan-Meier 生存分析计算无病生存期 (DFS) 和疾病特异性生存期 (DSS)。 在 303 篇文章中, 10 项研究(11 名患者, 72.7% 为男性)符合纳入标准, 平均年龄为 51.3 岁(范围: 12-77.5 岁)。 45.4% 的患者进行了术前细针穿刺细胞学检查, 其中 80% 的结果不确定。PPS-LS 的 两 年和 五年 DFS 率分别为 64% 和 50%, 而 两年 DSS 率为 84%。36.3% 的患者发生肿瘤复发, 平均每例患者复发 2.5 次, 尤其是 PPS-LS 的粘液样亚型。 本系统评价突显了 PPS-LS 及其亚型的不同预后结果, 强调需要进行警觉监测以改善 DFS 并降低复发率。 本研究为外科医生在处理 PPS-LS 的特定亚型时提供了对可能的预后结果的关键性理解。 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016489.2025.2462688
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 348
    Subjects:
      – SubjectFull: Head & neck cancer diagnosis
        Type: general
      – SubjectFull: Cytology
        Type: general
      – SubjectFull: Cancer relapse
        Type: general
      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Preoperative care
        Type: general
      – SubjectFull: Descriptive statistics
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      – SubjectFull: Liposarcoma
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      – SubjectFull: MEDLINE
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      – SubjectFull: Kaplan-Meier estimator
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      – SubjectFull: Needle biopsy
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      – SubjectFull: Online information services
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      – SubjectFull: Progression-free survival
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      – SubjectFull: Survival analysis (Biometry)
        Type: general
      – SubjectFull: Overall survival
        Type: general
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      – TitleFull: Diagnostic, survival, and tumor control outcomes of parapharyngeal space liposarcoma: a systematic review.
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              Text: Apr2025
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              Y: 2025
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