Gap-induced inhibition of the post-auricular muscle response in miniature pigs.
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| Title: | Gap-induced inhibition of the post-auricular muscle response in miniature pigs. |
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| Authors: | Zhou, Hanwen (AUTHOR), Liu, Peng (AUTHOR), Zhang, Chi (AUTHOR), Xue, Xinmiao (AUTHOR), Chen, Xuemin (AUTHOR), Zhang, Zhixin (AUTHOR), Shen, Weidong (AUTHOR), Yang, Shiming (AUTHOR), Fan, Mengyun (AUTHOR), Wang, Fangyuan (AUTHOR) |
| Source: | Acta Oto-Laryngologica. Apr2025, Vol. 145 Issue 4, p291-298. 8p. |
| Subjects: | Skeletal muscle physiology, Biological models, Acoustic reflex, Noise, Research funding, Tinnitus, Animal experimentation, Environmental exposure, Comparative studies, Disease risk factors |
| Abstract (English): | Background: Tinnitus, a persistent condition that significantly impairs the quality of life for patients, poses a substantial burden on society. Owing to its complex and poorly understood pathogenesis, the development of effective animal models for tinnitus is imperative to enhance our comprehension of this condition. Objectives: The present study aims to establish a large animal model to delineate the mechanisms underlying the onset of tinnitus. Materials and Methods: For the first time, we conducted a comparative analysis of the Post-Auricular Muscle Response (PAMR) and the Eye Blink Response (EBR) in miniature pigs, demonstrating their utility in manifesting Gap Prepulse Inhibition of the Acoustic Startle (GPIAS). Subsequently, we employed the gap-induced inhibition of PAMR to ascertain evidence of tinnitus following noise exposure. Results and Conclusion: Through comparing the efficacy of PAMR and EBR in GPIAS detection, we have substantiated that PAMR provides a stable and objective reflection of GPIAS. Consequently, PAMR emerges as a reliable method for measuring GPIAS in miniature pigs. Furthermore, the behavioral paradigm of gap-induced inhibition of PAMR successfully identified behavioral evidence of tinnitus subsequent to noise exposure. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): | 耳鸣是一种持续性疾病。它严重影响患者的生活质量, 给社会带来了沉重的负担。由于其复杂性且发病机制尚不明确, 开发有效的耳鸣动物模型对于增强我们对这种疾病的理解至关重要。 本研究旨在建立大型动物模型来表现耳鸣发作的机制。 我们首次对小型猪的耳后肌肉反应 (PAMR) 和眨眼反应 (EBR) 进行了比较分析, 证明了它们在表现间隙预脉冲抑制听觉惊吓 (GPIAS) 方面的用处。随后, 我们采用间隙诱导的 PAMR 抑制来确定噪声暴露后耳鸣的证据。 通过比较 PAMR 和 EBR 在 GPIAS 检测中的有效性, 我们证实 PAMR 可以稳定客观地反映 GPIAS。因此, PAMR 成为一种可靠的小型猪 GPIAS 测量方法。此外, 间隙诱导抑制 PAMR 的行为范式成功地识别出噪声暴露后耳鸣的行为证据。 [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background: Tinnitus, a persistent condition that significantly impairs the quality of life for patients, poses a substantial burden on society. Owing to its complex and poorly understood pathogenesis, the development of effective animal models for tinnitus is imperative to enhance our comprehension of this condition. Objectives: The present study aims to establish a large animal model to delineate the mechanisms underlying the onset of tinnitus. Materials and Methods: For the first time, we conducted a comparative analysis of the Post-Auricular Muscle Response (PAMR) and the Eye Blink Response (EBR) in miniature pigs, demonstrating their utility in manifesting Gap Prepulse Inhibition of the Acoustic Startle (GPIAS). Subsequently, we employed the gap-induced inhibition of PAMR to ascertain evidence of tinnitus following noise exposure. Results and Conclusion: Through comparing the efficacy of PAMR and EBR in GPIAS detection, we have substantiated that PAMR provides a stable and objective reflection of GPIAS. Consequently, PAMR emerges as a reliable method for measuring GPIAS in miniature pigs. Furthermore, the behavioral paradigm of gap-induced inhibition of PAMR successfully identified behavioral evidence of tinnitus subsequent to noise exposure. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00016489 |
| DOI: | 10.1080/00016489.2025.2464698 |
