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Somatosensory Evoked Potential N20 as a Prognostic Tool for Upper Limb Function in Stroke Patients: A Focus on Basal Ganglia and Thalamus.

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Title: Somatosensory Evoked Potential N20 as a Prognostic Tool for Upper Limb Function in Stroke Patients: A Focus on Basal Ganglia and Thalamus.
Authors: Yang, Shuai (AUTHOR), Chia, Chin-hsuan (AUTHOR), Xu, Pei-pei (AUTHOR), Zong, Ya (AUTHOR), Zhang, Weiming (AUTHOR), Sun, Xiao-pei (AUTHOR), Xu, Jing-yun (AUTHOR), Xie, Qing (AUTHOR), Fee, Dominic B. (AUTHOR)
Source: Acta Neurologica Scandinavica. 4/9/2025, Vol. 2025, p1-7. 7p.
Subjects: Somatosensory evoked potentials, Stroke patients, Rehabilitation, Basal ganglia, Prognostic tests, Thalamus, Forelimb
Abstract: Objective: This study is aimed at elucidating the prognostic utility of somatosensory evoked potentials (SEPs) N20 in the recovery of upper limb functionality among stroke patients with varying cerebral lesions. Methods: A cohort of 60 stroke patients enrolled in this study and stratified into two groups: 30 patients with strokes affecting the basal ganglia and 30 with thalamic involvement. Each patient underwent an SEP test after admission and participated in rehabilitation training for 3 months. Assessments were carried out using the Fugl–Meyer Assessment for Upper Extremity (FMA‐UE), the Modified Ashworth Scale (MAS), and the Modified Barthel Index (MBI) at admission and 3 months after treatment to analyze the correlation between SEP‐N20 indices and the function assessment scales in the two groups. Results: (1) SEP in stroke patients revealed notable abnormalities, in which a more pronounced reduction of the amplitude ratio of the N20 (SEPAR‐N20) wave between the affected and unaffected sides was observed in the thalamus group (p < 0.05). (2) After 3 months, a significant positive correlation was established between the improvement rate of FMA‐UE scores and SEPAR‐N20 in the basal ganglia group (r = 0.696, p < 0.0001). Conversely, this correlation was not evident within the thalamus group (r = −0.157, p > 0.05). (3) There was no significant correlation between MAS or MBI scores and SEPAR‐N20 in either group (p > 0.05). Conclusion: The extent of SEP abnormality poststroke is associated with the location of the lesion. Strokes involving the thalamus exhibited more pronounced changes in the N20 component. SEPAR‐N20 might serve as a valuable predictor for the recovery of upper limb functionality, particularly in cases of basal ganglia strokes. Trial Registration: Chinese Clinical Trial Registry: ChiCTR2300075570 [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Somatosensory Evoked Potential N20 as a Prognostic Tool for Upper Limb Function in Stroke Patients: A Focus on Basal Ganglia and Thalamus.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yang%2C+Shuai%22&quot;&gt;Yang, Shuai&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chia%2C+Chin-hsuan%22&quot;&gt;Chia, Chin-hsuan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xu%2C+Pei-pei%22&quot;&gt;Xu, Pei-pei&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zong%2C+Ya%22&quot;&gt;Zong, Ya&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Weiming%22&quot;&gt;Zhang, Weiming&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sun%2C+Xiao-pei%22&quot;&gt;Sun, Xiao-pei&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xu%2C+Jing-yun%22&quot;&gt;Xu, Jing-yun&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xie%2C+Qing%22&quot;&gt;Xie, Qing&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fee%2C+Dominic+B%2E%22&quot;&gt;Fee, Dominic B.&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Acta+Neurologica+Scandinavica%22&quot;&gt;Acta Neurologica Scandinavica&lt;/searchLink&gt;. 4/9/2025, Vol. 2025, p1-7. 7p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Somatosensory+evoked+potentials%22&quot;&gt;Somatosensory evoked potentials&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Stroke+patients%22&quot;&gt;Stroke patients&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Rehabilitation%22&quot;&gt;Rehabilitation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Basal+ganglia%22&quot;&gt;Basal ganglia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Prognostic+tests%22&quot;&gt;Prognostic tests&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Thalamus%22&quot;&gt;Thalamus&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Forelimb%22&quot;&gt;Forelimb&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: This study is aimed at elucidating the prognostic utility of somatosensory evoked potentials (SEPs) N20 in the recovery of upper limb functionality among stroke patients with varying cerebral lesions. Methods: A cohort of 60 stroke patients enrolled in this study and stratified into two groups: 30 patients with strokes affecting the basal ganglia and 30 with thalamic involvement. Each patient underwent an SEP test after admission and participated in rehabilitation training for 3 months. Assessments were carried out using the Fugl–Meyer Assessment for Upper Extremity (FMA‐UE), the Modified Ashworth Scale (MAS), and the Modified Barthel Index (MBI) at admission and 3 months after treatment to analyze the correlation between SEP‐N20 indices and the function assessment scales in the two groups. Results: (1) SEP in stroke patients revealed notable abnormalities, in which a more pronounced reduction of the amplitude ratio of the N20 (SEPAR‐N20) wave between the affected and unaffected sides was observed in the thalamus group (p &lt; 0.05). (2) After 3 months, a significant positive correlation was established between the improvement rate of FMA‐UE scores and SEPAR‐N20 in the basal ganglia group (r = 0.696, p &lt; 0.0001). Conversely, this correlation was not evident within the thalamus group (r = −0.157, p &gt; 0.05). (3) There was no significant correlation between MAS or MBI scores and SEPAR‐N20 in either group (p &gt; 0.05). Conclusion: The extent of SEP abnormality poststroke is associated with the location of the lesion. Strokes involving the thalamus exhibited more pronounced changes in the N20 component. SEPAR‐N20 might serve as a valuable predictor for the recovery of upper limb functionality, particularly in cases of basal ganglia strokes. Trial Registration: Chinese Clinical Trial Registry: ChiCTR2300075570 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1155/ane/2060433
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 1
    Subjects:
      – SubjectFull: Somatosensory evoked potentials
        Type: general
      – SubjectFull: Stroke patients
        Type: general
      – SubjectFull: Rehabilitation
        Type: general
      – SubjectFull: Basal ganglia
        Type: general
      – SubjectFull: Prognostic tests
        Type: general
      – SubjectFull: Thalamus
        Type: general
      – SubjectFull: Forelimb
        Type: general
    Titles:
      – TitleFull: Somatosensory Evoked Potential N20 as a Prognostic Tool for Upper Limb Function in Stroke Patients: A Focus on Basal Ganglia and Thalamus.
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            – D: 09
              M: 04
              Text: 4/9/2025
              Type: published
              Y: 2025
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