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Subregional alterations in corpus callosum is associated with different symptoms in early-stage parkinson's disease.

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Title: Subregional alterations in corpus callosum is associated with different symptoms in early-stage parkinson's disease.
Authors: Wei, Jiahao (AUTHOR), Liu, Zhihui (AUTHOR), Su, Huahua (AUTHOR), She, Yuchen (AUTHOR), Wang, Junyi (AUTHOR), Liu, Ying (AUTHOR), Zhong, Yuke (AUTHOR), Mo, Lijuan (AUTHOR), Tan, Changhong (AUTHOR), Liu, Xi (AUTHOR), Chen, Lifen (AUTHOR)
Source: Neurological Sciences. May2025, Vol. 46 Issue 5, p2115-2127. 13p.
Subjects: Diffusion tensor imaging, Leukoencephalopathies, Parkinson's disease, Diffusion magnetic resonance imaging, Corpus callosum
Abstract: Objective: Corpus callosum (CC) damage is the most consistent and typical change in early Parkinson's disease (PD), and is associated with various PD symptoms. However, the precise relationship between CC subregions and specific PD symptoms have not been identified comprehensively. In this study, we investigated the association between specific CC subregion alterations and PD symptoms using diffusion-weighted imaging. Methods: 70 PD patients in early-stage from the Parkinson's Progression Markers Initiative cohort were included. Fixel-based analysis (FBA) was used to calculate mean values of fiber density (FD), fiber cross-section (FC), and combined measure of FD and FC (FDC) for 7 CC subregions. Regression analyses between FBA metrics and PD symptom scores were performed to evaluate associations between CC subregion metrics and clinical symptom scores. Diffusion tensor imaging (DTI) metrics were also analyzed. Results: The score of akinetic rigid symptoms was negatively associated with FDC value of CC rostral body. The score of Activities of Daily Living was positively associated with FD value of CC anterior midbody. The score of gastrointestinal dysfunction was negatively associated with FDC value of CC rostrum. The severity of thermoregulatory dysfunction and cognitive decline was accompanied by an improvement in FBA metrics for several CC subregions. No significant associations were found using DTI metrics. Conclusions: In early-stage of PD, motor, autonomic, and cognitive functions are associated with specific subregions of CC, and compensatory changes in CC may exist to maintain normal autonomic and cognitive functions. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Subregional alterations in corpus callosum is associated with different symptoms in early-stage parkinson's disease.
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  Data: <searchLink fieldCode="AR" term="%22Wei%2C+Jiahao%22">Wei, Jiahao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Zhihui%22">Liu, Zhihui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Su%2C+Huahua%22">Su, Huahua</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22She%2C+Yuchen%22">She, Yuchen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Junyi%22">Wang, Junyi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Ying%22">Liu, Ying</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhong%2C+Yuke%22">Zhong, Yuke</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mo%2C+Lijuan%22">Mo, Lijuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tan%2C+Changhong%22">Tan, Changhong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Xi%22">Liu, Xi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Lifen%22">Chen, Lifen</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. May2025, Vol. 46 Issue 5, p2115-2127. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Diffusion+tensor+imaging%22">Diffusion tensor imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Leukoencephalopathies%22">Leukoencephalopathies</searchLink><br /><searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion+magnetic+resonance+imaging%22">Diffusion magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Corpus+callosum%22">Corpus callosum</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objective: Corpus callosum (CC) damage is the most consistent and typical change in early Parkinson's disease (PD), and is associated with various PD symptoms. However, the precise relationship between CC subregions and specific PD symptoms have not been identified comprehensively. In this study, we investigated the association between specific CC subregion alterations and PD symptoms using diffusion-weighted imaging. Methods: 70 PD patients in early-stage from the Parkinson's Progression Markers Initiative cohort were included. Fixel-based analysis (FBA) was used to calculate mean values of fiber density (FD), fiber cross-section (FC), and combined measure of FD and FC (FDC) for 7 CC subregions. Regression analyses between FBA metrics and PD symptom scores were performed to evaluate associations between CC subregion metrics and clinical symptom scores. Diffusion tensor imaging (DTI) metrics were also analyzed. Results: The score of akinetic rigid symptoms was negatively associated with FDC value of CC rostral body. The score of Activities of Daily Living was positively associated with FD value of CC anterior midbody. The score of gastrointestinal dysfunction was negatively associated with FDC value of CC rostrum. The severity of thermoregulatory dysfunction and cognitive decline was accompanied by an improvement in FBA metrics for several CC subregions. No significant associations were found using DTI metrics. Conclusions: In early-stage of PD, motor, autonomic, and cognitive functions are associated with specific subregions of CC, and compensatory changes in CC may exist to maintain normal autonomic and cognitive functions. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: May2025
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