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Plasma levels of glial fibrillary acidic protein and neurofilament light chain in patients with chronic migraine: a multicenter case-control study.

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Title: Plasma levels of glial fibrillary acidic protein and neurofilament light chain in patients with chronic migraine: a multicenter case-control study.
Authors: Colombo, Eleonora (AUTHOR), Doretti, Alberto (AUTHOR), Rao, Renata (AUTHOR), Verde, Federico (AUTHOR), Sodano, Martina (AUTHOR), De Gobbi, Anna (AUTHOR), di Cola, Francesca Schiano (AUTHOR), Ceccardi, Giulia (AUTHOR), Fiducia, Beatrice (AUTHOR), Quaresima, Virginia (AUTHOR), Tolassi, Chiara (AUTHOR), Rizzardi, Andrea (AUTHOR), Pierro, Simone (AUTHOR), Thirumoorthi, Vineetha (AUTHOR), Bettinelli, Arianna (AUTHOR), Ungaro, Daniela (AUTHOR), Ratti, Antonia (AUTHOR), Silani, Vincenzo (AUTHOR), Messina, Stefano (AUTHOR), Pilotto, Andrea (AUTHOR)
Source: Neurological Sciences. May2025, Vol. 46 Issue 5, p2209-2216. 8p.
Subjects: Glial fibrillary acidic protein, Migraine aura, Single molecules, Sexual dimorphism, Migraine
Abstract: Objective: Plasma glial fibrillary acidic protein (pGFAP) and plasma neurofilament light chain (pNfL) levels reflect astrocyte activation and neuronal damage, respectively. Whether these phenomena play a role in migraine is unknown. This study aimed to compare pGFAP and pNfL levels in patients with chronic migraine (CM) and age-matched controls and to analyze their relation with clinical features. Methods: The study evaluated two independent cohorts of patients, including in total 58 CM and 69 controls. pGFAP and pNfL were quantified with single molecule array (Simoa) technology. Demographic and clinical data were collected for each subject; differences in NfL/GFAP levels between CM and controls were evaluated in analyses adjusted for the effect of age and sex; clinical characteristics associated with NfL/GFAP levels were separately evaluated in the two cohorts. Results: In both cohorts, we did not find a significant difference in pGFAP or pNFL levels between CM and matched controls. The study did not find any correlation between pGFAP or pNfL levels and any migraine characteristics (namely presence of migraine aura, attack frequency, migraine intensity, years of disease). Conclusions: Our negative results support the assumption that migraine represents a benign condition, characterized by transient functional brain alterations and not by the accumulation over time of neuroaxonal damage and/or associated astrocyte activation detectable by neurodegeneration marker proteins. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Plasma levels of glial fibrillary acidic protein and neurofilament light chain in patients with chronic migraine: a multicenter case-control study.
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. May2025, Vol. 46 Issue 5, p2209-2216. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Glial+fibrillary+acidic+protein%22">Glial fibrillary acidic protein</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine+aura%22">Migraine aura</searchLink><br /><searchLink fieldCode="DE" term="%22Single+molecules%22">Single molecules</searchLink><br /><searchLink fieldCode="DE" term="%22Sexual+dimorphism%22">Sexual dimorphism</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine%22">Migraine</searchLink>
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  Label: Abstract
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  Data: Objective: Plasma glial fibrillary acidic protein (pGFAP) and plasma neurofilament light chain (pNfL) levels reflect astrocyte activation and neuronal damage, respectively. Whether these phenomena play a role in migraine is unknown. This study aimed to compare pGFAP and pNfL levels in patients with chronic migraine (CM) and age-matched controls and to analyze their relation with clinical features. Methods: The study evaluated two independent cohorts of patients, including in total 58 CM and 69 controls. pGFAP and pNfL were quantified with single molecule array (Simoa) technology. Demographic and clinical data were collected for each subject; differences in NfL/GFAP levels between CM and controls were evaluated in analyses adjusted for the effect of age and sex; clinical characteristics associated with NfL/GFAP levels were separately evaluated in the two cohorts. Results: In both cohorts, we did not find a significant difference in pGFAP or pNFL levels between CM and matched controls. The study did not find any correlation between pGFAP or pNfL levels and any migraine characteristics (namely presence of migraine aura, attack frequency, migraine intensity, years of disease). Conclusions: Our negative results support the assumption that migraine represents a benign condition, characterized by transient functional brain alterations and not by the accumulation over time of neuroaxonal damage and/or associated astrocyte activation detectable by neurodegeneration marker proteins. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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