View in EDS HTML Full Text PDF Full Text

Examination of empathy-like behaviour in nicotine-preferring rat lines.

Saved in:
Bibliographic Details
Title: Examination of empathy-like behaviour in nicotine-preferring rat lines.
Authors: Demirel, Sinem (AUTHOR), Tuzcu, Fulya (AUTHOR), Uysal Harzadin, Nazan (AUTHOR), Kandiş, Sevim (AUTHOR), Kızıldağ, Servet (AUTHOR), Kanıt, Lütfiye (AUTHOR)
Source: International Journal of Neuroscience. May2025, Vol. 135 Issue 5, p544-552. 9p.
Subjects: Oxytocin receptors, Vasopressin, Oxytocin, Maze tests, Prefrontal cortex
Abstract: Aim: Addiction is an important global health issue, impacting also addicts environment and society. Empathy plays crucial role in establishing successful social relationships and is a fundamental component of social life. The aim of this study is to investigate how nicotine preferring (NP) strain and oral forced nicotine administration affects empathy-like behaviour in rats, with gender differences. Materials and Methods: Sprague-Dawley NP rats (10 males/10 females) and wild-type control rats (10 males/10 females) were used. Behavioural tests were administered to all rats before and after oral forced nicotine administration. The behavioural tests were completed in the fourth week of nicotine administration. Anxiety levels that could affect empathy-like behaviour were evaluated with open field, elevated plus maze tests and with blood cortisol levels. Oxytocin receptor and arginine vasopressin (AVP) levels, which have been shown to be related to empathy-like behaviour, were examined in the prefrontal cortex and amygdala regions using the enzyme-linked immunoassay method. Results: It was observed that males from the NP strain showed less empathy-like behaviour than all other groups, and nicotine administration did not cause a significant change in the results. Higher levels of locomotor activity (LA) were found in control females than in all other groups. Blood nicotine and corticosterone levels were higher in NP rats. No significant differences were found in AVP and oxytocin receptor levels in the prefrontal cortex and amygdala. Conclusions: It was found that coming from an addicted strain particularly reduces empathy-like behaviour in males. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 184789283
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Examination of empathy-like behaviour in nicotine-preferring rat lines.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Demirel%2C+Sinem%22">Demirel, Sinem</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tuzcu%2C+Fulya%22">Tuzcu, Fulya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Uysal+Harzadin%2C+Nazan%22">Uysal Harzadin, Nazan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kandiş%2C+Sevim%22">Kandiş, Sevim</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kızıldağ%2C+Servet%22">Kızıldağ, Servet</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kanıt%2C+Lütfiye%22">Kanıt, Lütfiye</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. May2025, Vol. 135 Issue 5, p544-552. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Oxytocin+receptors%22">Oxytocin receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Vasopressin%22">Vasopressin</searchLink><br /><searchLink fieldCode="DE" term="%22Oxytocin%22">Oxytocin</searchLink><br /><searchLink fieldCode="DE" term="%22Maze+tests%22">Maze tests</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aim: Addiction is an important global health issue, impacting also addicts environment and society. Empathy plays crucial role in establishing successful social relationships and is a fundamental component of social life. The aim of this study is to investigate how nicotine preferring (NP) strain and oral forced nicotine administration affects empathy-like behaviour in rats, with gender differences. Materials and Methods: Sprague-Dawley NP rats (10 males/10 females) and wild-type control rats (10 males/10 females) were used. Behavioural tests were administered to all rats before and after oral forced nicotine administration. The behavioural tests were completed in the fourth week of nicotine administration. Anxiety levels that could affect empathy-like behaviour were evaluated with open field, elevated plus maze tests and with blood cortisol levels. Oxytocin receptor and arginine vasopressin (AVP) levels, which have been shown to be related to empathy-like behaviour, were examined in the prefrontal cortex and amygdala regions using the enzyme-linked immunoassay method. Results: It was observed that males from the NP strain showed less empathy-like behaviour than all other groups, and nicotine administration did not cause a significant change in the results. Higher levels of locomotor activity (LA) were found in control females than in all other groups. Blood nicotine and corticosterone levels were higher in NP rats. No significant differences were found in AVP and oxytocin receptor levels in the prefrontal cortex and amygdala. Conclusions: It was found that coming from an addicted strain particularly reduces empathy-like behaviour in males. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=184789283
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00207454.2024.2312989
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 544
    Subjects:
      – SubjectFull: Oxytocin receptors
        Type: general
      – SubjectFull: Vasopressin
        Type: general
      – SubjectFull: Oxytocin
        Type: general
      – SubjectFull: Maze tests
        Type: general
      – SubjectFull: Prefrontal cortex
        Type: general
    Titles:
      – TitleFull: Examination of empathy-like behaviour in nicotine-preferring rat lines.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Demirel, Sinem
      – PersonEntity:
          Name:
            NameFull: Tuzcu, Fulya
      – PersonEntity:
          Name:
            NameFull: Uysal Harzadin, Nazan
      – PersonEntity:
          Name:
            NameFull: Kandiş, Sevim
      – PersonEntity:
          Name:
            NameFull: Kızıldağ, Servet
      – PersonEntity:
          Name:
            NameFull: Kanıt, Lütfiye
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 00207454
          Numbering:
            – Type: volume
              Value: 135
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: International Journal of Neuroscience
              Type: main
ResultId 1