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Examining the causal relationship between hypertension and benign paroxysmal vertigo: a univariate and multivariate Mendelian randomization study.

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Title: Examining the causal relationship between hypertension and benign paroxysmal vertigo: a univariate and multivariate Mendelian randomization study.
Authors: Wang, Luyao (AUTHOR), Cui, Feilun (AUTHOR), Chen, Xiangping (AUTHOR), Zhang, Qing (AUTHOR), Yang, Jun (AUTHOR), Li, Shuna (AUTHOR)
Source: Acta Oto-Laryngologica. May2025, Vol. 145 Issue 5, p400-408. 9p.
Subjects: Hypertension risk factors, Risk assessment, Research funding, Descriptive statistics, Multivariate analysis, Benign paroxysmal positional vertigo, Odds ratio, Statistics, Data analysis software, Confidence intervals, Single nucleotide polymorphisms, Disease complications
Abstract (English): Background: Patients with benign paroxysmal positional vertigo (BPPV) may be at increased risk for hypertension. Objectives: To examine the causal relationship between hypertensive disorders and benign paroxysmal vertigo (BPV). Materials and methods: A bidirectional two-sample Mendelian randomization (MR) study was conducted to assess the causal relationship between hypertension and BPV. Summary statistics for BPV and hypertension were obtained from the FinnGen biobank to support the primary MR analysis. Five complementary methods – inverse variance weighted, weighted median, MR-Egger, simple mode, and weighted mode – were applied to obtain MR estimates. Furthermore, a multivariable MR (MVMR) analysis was conducted to examine whether hypertension independently influences BPV. Results: The MR analysis indicated a significant causal effect of hypertension on BPV, with an odds ratio (OR) of 1.11 (95% CI: 1.02–1.22, p =.019), indicating an increased risk of BPV associated with hypertension. MVMR analysis further indicated that the causal effect of hypertension on BPV remained significant even after adjusting for menopausal disorders and ischemic stroke (OR: 1.108, 95% CI: 1.003–1.225, p =.043). Conclusions and significance: This MR study provided evidence supporting a causal effect of hypertension on BPV. [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 背景：良性阵发性位置性眩晕 (BPPV) 患者患高血压的风险可能会增加。 目的：研究高血压疾病与良性阵发性眩晕 (BPV) 之间的因果关系。 材料和方法：进行了双向双样本孟德尔随机化 (MR) 研究, 以评估高血压与 BPV 之间的因果关系。从 FinnGen 生物库获取了 BPV 和高血压的汇总统计数据, 以支持初级 MR 分析。应用了五种互补方法（逆方差加权、加权中位数、MR-Egger、简单模式和加权模式）来获得 MR 估计值。此外, 还进行了多变量 MR (MVMR) 分析, 以检查高血压是否独立影响 BPV。 结果：MR 分析表明, 高血压对 BPV 具有显著的因果效应, 比值比 (OR) 为 1.11（95% CI：1.02–1.22, p =.019）, 表明与高血压相关的BPV的风险增加。MVMR 分析进一步表明, 即使在调整更年期障碍和缺血性中风后, 高血压对 BPV 的因果效应仍然显著（OR：1.108, 95% CI：1.003–1.225, p =.043）。 结论和意义：这项 MR 研究提供了支持高血压对 BPV 的因果效应的证据。 [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Examining the causal relationship between hypertension and benign paroxysmal vertigo: a univariate and multivariate Mendelian randomization study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Luyao%22">Wang, Luyao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cui%2C+Feilun%22">Cui, Feilun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Xiangping%22">Chen, Xiangping</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Qing%22">Zhang, Qing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Jun%22">Yang, Jun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Shuna%22">Li, Shuna</searchLink> (AUTHOR)
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  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. May2025, Vol. 145 Issue 5, p400-408. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Hypertension+risk+factors%22">Hypertension risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Benign+paroxysmal+positional+vertigo%22">Benign paroxysmal positional vertigo</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Single+nucleotide+polymorphisms%22">Single nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Background: Patients with benign paroxysmal positional vertigo (BPPV) may be at increased risk for hypertension. Objectives: To examine the causal relationship between hypertensive disorders and benign paroxysmal vertigo (BPV). Materials and methods: A bidirectional two-sample Mendelian randomization (MR) study was conducted to assess the causal relationship between hypertension and BPV. Summary statistics for BPV and hypertension were obtained from the FinnGen biobank to support the primary MR analysis. Five complementary methods – inverse variance weighted, weighted median, MR-Egger, simple mode, and weighted mode – were applied to obtain MR estimates. Furthermore, a multivariable MR (MVMR) analysis was conducted to examine whether hypertension independently influences BPV. Results: The MR analysis indicated a significant causal effect of hypertension on BPV, with an odds ratio (OR) of 1.11 (95% CI: 1.02–1.22, p =.019), indicating an increased risk of BPV associated with hypertension. MVMR analysis further indicated that the causal effect of hypertension on BPV remained significant even after adjusting for menopausal disorders and ischemic stroke (OR: 1.108, 95% CI: 1.003–1.225, p =.043). Conclusions and significance: This MR study provided evidence supporting a causal effect of hypertension on BPV. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Chinese)
  Group: Ab
  Data: 背景：良性阵发性位置性眩晕 (BPPV) 患者患高血压的风险可能会增加。 目的：研究高血压疾病与良性阵发性眩晕 (BPV) 之间的因果关系。 材料和方法：进行了双向双样本孟德尔随机化 (MR) 研究, 以评估高血压与 BPV 之间的因果关系。从 FinnGen 生物库获取了 BPV 和高血压的汇总统计数据, 以支持初级 MR 分析。应用了五种互补方法（逆方差加权、加权中位数、MR-Egger、简单模式和加权模式）来获得 MR 估计值。此外, 还进行了多变量 MR (MVMR) 分析, 以检查高血压是否独立影响 BPV。 结果：MR 分析表明, 高血压对 BPV 具有显著的因果效应, 比值比 (OR) 为 1.11（95% CI：1.02–1.22, p =.019）, 表明与高血压相关的BPV的风险增加。MVMR 分析进一步表明, 即使在调整更年期障碍和缺血性中风后, 高血压对 BPV 的因果效应仍然显著（OR：1.108, 95% CI：1.003–1.225, p =.043）。 结论和意义：这项 MR 研究提供了支持高血压对 BPV 的因果效应的证据。 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016489.2025.2479015
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 400
    Subjects:
      – SubjectFull: Hypertension risk factors
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Multivariate analysis
        Type: general
      – SubjectFull: Benign paroxysmal positional vertigo
        Type: general
      – SubjectFull: Odds ratio
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Single nucleotide polymorphisms
        Type: general
      – SubjectFull: Disease complications
        Type: general
    Titles:
      – TitleFull: Examining the causal relationship between hypertension and benign paroxysmal vertigo: a univariate and multivariate Mendelian randomization study.
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            NameFull: Wang, Luyao
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              M: 05
              Text: May2025
              Type: published
              Y: 2025
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