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The Task‐Based fMRI Using von Zerssen Scale in Recurrent Depression Disorder: A Replication Study.

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Title: The Task‐Based fMRI Using von Zerssen Scale in Recurrent Depression Disorder: A Replication Study.
Authors: Korotkov, Alexander (AUTHOR), Myznikov, Artem (AUTHOR), Komarova, Anastasia (AUTHOR), Isaeva, Elena (AUTHOR), Solnyshkina, Irina (AUTHOR), Cherednichenko, Denis (AUTHOR), Didur, Michael (AUTHOR), Kireev, Maxim (AUTHOR), Stoyanov, Drozdstoy (AUTHOR)
Source: Depression & Anxiety (1091-4269). 5/1/2025, Vol. 2025, p1-8. 8p.
Subjects: Functional magnetic resonance imaging, Mental depression, Psychiatry, Neurophysiology, Pathological physiology, Brain imaging, Psychodiagnostics
Abstract: Currently, translation into clinical practice of scientific knowledge on pathological reorganization of brain mechanisms in psychiatric disorders, as suggested by functional neuroimaging data, remains limited. This situation calls for the exploration of new approaches, which were recently proposed for the combined use of the simultaneous application of psychodiagnostic testing and fMRI scanning. Consequently, a self‐rated psychodiagnostic scale was used as an experimental task during fMRI scanning for patients with major depressive disorder. Given the promising neuroimaging results obtained in these studies, in current research, our objective was to replicate these results and conduct an fMRI study using statements from the von Zerssen depression as experimental conditions. Eighteen patients with recurrent depressive disorder and healthy volunteers participated in the study to replicate the group size of previous research. The results obtained showed that patients with recurrent depressive disorder exhibited greater activity in the right precuneus and bilateral supramarginal gyrus than healthy controls while responding to diagnostically specific (DS) statements compared to diagnostically neutral (DN) ones. These findings replicate the main results of the original study and emphasize the potential of this approach in the field of translational psychiatry. In addition, they contribute to understanding the pathophysiological mechanisms of depression through the use of this unique fMRI paradigm. [ABSTRACT FROM AUTHOR]
Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The Task‐Based fMRI Using von Zerssen Scale in Recurrent Depression Disorder: A Replication Study.
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  Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. 5/1/2025, Vol. 2025, p1-8. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatry%22">Psychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22Neurophysiology%22">Neurophysiology</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+physiology%22">Pathological physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Psychodiagnostics%22">Psychodiagnostics</searchLink>
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  Data: Currently, translation into clinical practice of scientific knowledge on pathological reorganization of brain mechanisms in psychiatric disorders, as suggested by functional neuroimaging data, remains limited. This situation calls for the exploration of new approaches, which were recently proposed for the combined use of the simultaneous application of psychodiagnostic testing and fMRI scanning. Consequently, a self‐rated psychodiagnostic scale was used as an experimental task during fMRI scanning for patients with major depressive disorder. Given the promising neuroimaging results obtained in these studies, in current research, our objective was to replicate these results and conduct an fMRI study using statements from the von Zerssen depression as experimental conditions. Eighteen patients with recurrent depressive disorder and healthy volunteers participated in the study to replicate the group size of previous research. The results obtained showed that patients with recurrent depressive disorder exhibited greater activity in the right precuneus and bilateral supramarginal gyrus than healthy controls while responding to diagnostically specific (DS) statements compared to diagnostically neutral (DN) ones. These findings replicate the main results of the original study and emphasize the potential of this approach in the field of translational psychiatry. In addition, they contribute to understanding the pathophysiological mechanisms of depression through the use of this unique fMRI paradigm. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=184868918
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        Value: 10.1155/da/2617054
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        Text: English
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      – SubjectFull: Mental depression
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      – SubjectFull: Psychiatry
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      – SubjectFull: Neurophysiology
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      – SubjectFull: Pathological physiology
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      – SubjectFull: Brain imaging
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      – SubjectFull: Psychodiagnostics
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      – TitleFull: The Task‐Based fMRI Using von Zerssen Scale in Recurrent Depression Disorder: A Replication Study.
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              M: 05
              Text: 5/1/2025
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              Y: 2025
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