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Research Review: A review of the past decade of family and genomic studies on adolescent mental health.

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Title: Research Review: A review of the past decade of family and genomic studies on adolescent mental health.
Authors: Morneau‐Vaillancourt, Geneviève, Palaiologou, Elisavet, Polderman, Tinca J.C., Eley, Thalia C.
Source: Journal of Child Psychology & Psychiatry. Jun2025, Vol. 66 Issue 6, p910-927. 18p.
Subjects: Mental illness genetics, Adolescent development, Psychotherapy, Genomics, Treatment effectiveness, Adolescent psychology, Environmental exposure, Comorbidity, Pathological psychology, Intergenerational relations, Genetics, Phenotypes, Adolescence
Abstract: Background: Mental health problems and traits capturing psychopathology are common and often begin during adolescence. Decades of twin studies indicate that genetic factors explain around 50% of individual differences in adolescent psychopathology. In recent years, significant advances, particularly in genomics, have moved this work towards more translational findings. Methods: This review provides an overview of the past decade of genetically sensitive studies on adolescent development, covering both family and genomic studies in adolescents aged 10–24 years. We focus on five research themes: (1) co‐occurrence or comorbidity between psychopathologies, (2) stability and change over time, (3) intergenerational transmission, (4) gene–environment interplay, and (5) psychological treatment outcomes. Results: First, research shows that much of the co‐occurrence of psychopathologies in adolescence is explained by genetic factors, with widespread pleiotropic influences on many traits. Second, stability in psychopathology across adolescence is largely explained by persistent genetic influences, whereas change is explained by emerging genetic and environmental influences. Third, contemporary twin‐family studies suggest that different co‐occurring genetic and environmental mechanisms may account for the intergenerational transmission of psychopathology, with some differences across psychopathologies. Fourth, genetic influences on adolescent psychopathology are correlated with a wide range of environmental exposures. However, the extent to which genetic factors interact with the environment remains unclear, as findings from both twin and genomic studies are inconsistent. Finally, a few studies suggest that genetic factors may play a role in psychological treatment response, but these findings have not yet been replicated. Conclusions: Genetically sensitive research on adolescent psychopathology has progressed significantly in the past decade, with family and twin findings starting to be replicated at the genomic level. However, important gaps remain in the literature, and we conclude by providing suggestions of research questions that still need to be addressed. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Research Review: A review of the past decade of family and genomic studies on adolescent mental health.
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Psychology+%26+Psychiatry%22">Journal of Child Psychology & Psychiatry</searchLink>. Jun2025, Vol. 66 Issue 6, p910-927. 18p.
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  Data: <searchLink fieldCode="DE" term="%22Mental+illness+genetics%22">Mental illness genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescent+development%22">Adolescent development</searchLink><br /><searchLink fieldCode="DE" term="%22Psychotherapy%22">Psychotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Genomics%22">Genomics</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescent+psychology%22">Adolescent psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Intergenerational+relations%22">Intergenerational relations</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescence%22">Adolescence</searchLink>
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  Data: Background: Mental health problems and traits capturing psychopathology are common and often begin during adolescence. Decades of twin studies indicate that genetic factors explain around 50% of individual differences in adolescent psychopathology. In recent years, significant advances, particularly in genomics, have moved this work towards more translational findings. Methods: This review provides an overview of the past decade of genetically sensitive studies on adolescent development, covering both family and genomic studies in adolescents aged 10–24 years. We focus on five research themes: (1) co‐occurrence or comorbidity between psychopathologies, (2) stability and change over time, (3) intergenerational transmission, (4) gene–environment interplay, and (5) psychological treatment outcomes. Results: First, research shows that much of the co‐occurrence of psychopathologies in adolescence is explained by genetic factors, with widespread pleiotropic influences on many traits. Second, stability in psychopathology across adolescence is largely explained by persistent genetic influences, whereas change is explained by emerging genetic and environmental influences. Third, contemporary twin‐family studies suggest that different co‐occurring genetic and environmental mechanisms may account for the intergenerational transmission of psychopathology, with some differences across psychopathologies. Fourth, genetic influences on adolescent psychopathology are correlated with a wide range of environmental exposures. However, the extent to which genetic factors interact with the environment remains unclear, as findings from both twin and genomic studies are inconsistent. Finally, a few studies suggest that genetic factors may play a role in psychological treatment response, but these findings have not yet been replicated. Conclusions: Genetically sensitive research on adolescent psychopathology has progressed significantly in the past decade, with family and twin findings starting to be replicated at the genomic level. However, important gaps remain in the literature, and we conclude by providing suggestions of research questions that still need to be addressed. [ABSTRACT FROM AUTHOR]
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  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/jcpp.14099
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        Text: English
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        PageCount: 18
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      – SubjectFull: Mental illness genetics
        Type: general
      – SubjectFull: Adolescent development
        Type: general
      – SubjectFull: Psychotherapy
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      – SubjectFull: Genomics
        Type: general
      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Adolescent psychology
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      – SubjectFull: Environmental exposure
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      – SubjectFull: Comorbidity
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      – SubjectFull: Pathological psychology
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      – SubjectFull: Intergenerational relations
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      – SubjectFull: Phenotypes
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      – SubjectFull: Adolescence
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      – TitleFull: Research Review: A review of the past decade of family and genomic studies on adolescent mental health.
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              Text: Jun2025
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