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Long-term health-related quality of life among adolescent and young adult breast cancer survivors.

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Title: Long-term health-related quality of life among adolescent and young adult breast cancer survivors.
Authors: Vrancken Peeters, Noelle J. M. C. (AUTHOR), Kerklaan, Roos (AUTHOR), Vlooswijk, Carla (AUTHOR), Bijlsma, Rhodé M. (AUTHOR), Kaal, Suzanne E. J. (AUTHOR), Tromp, Jacqueline M. (AUTHOR), Bos, Monique E. M. M. (AUTHOR), van der Hulle, Tom (AUTHOR), de Boer, Maaike (AUTHOR), Nuver, Janine (AUTHOR), Kouwenhoven, Mathilde C. M. (AUTHOR), van der Graaf, Winette T. A. (AUTHOR), Husson, Olga (AUTHOR)
Source: Quality of Life Research. May2025, Vol. 34 Issue 5, p1483-1500. 18p.
Subjects: Quality of life, Cancer survivors, Patient care, Teenagers, Quality of life measurement, Functional assessment, Symptoms
Abstract: Purpose: As the prognosis for adolescents and young adults (AYAs) with breast cancer has improved, long-term health-related quality of life (HRQoL) has become increasingly important. This study aimed to analyze the long-term HRQoL of AYA breast cancer survivors compared to an age-matched normative population and to identify factors associated with HRQoL. Methods: Secondary analyses were conducted using data from the SURVAYA study. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30) was used to assess HRQoL. The Mann–Whitney U test was used to compare HRQoL scores of AYA breast cancer survivors with those of the normative population (n = 409). Linear regression models were constructed to identify patient and treatment characteristics associated with HRQoL. Results: A total of 944 female AYA breast cancer survivors were included, with a median age of 36.0 years and a median follow-up of 12.2 years. AYA breast cancer survivors scored significantly lower on five functional scales: physical, role, emotional, cognitive, and social, and higher on five symptom scales: fatigue, pain, dyspnea, insomnia, and financial impact compared to the normative population. Being in a relationship, having a positive body image, and adaptive coping were positively associated with HRQoL, while older age, chemotherapy, unemployment, and maladaptive coping were negatively associated. Conclusion: AYA breast cancer survivors experience significantly compromised long-term HRQoL compared to an age-matched normative population. These results highlight the need for tailored follow-up care and long-term support, as well as the importance of shared decision-making about the benefits and risks of treatments before initiation. [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Long-term health-related quality of life among adolescent and young adult breast cancer survivors.
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  Data: <searchLink fieldCode="AR" term="%22Vrancken+Peeters%2C+Noelle+J%2E+M%2E+C%2E%22">Vrancken Peeters, Noelle J. M. C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kerklaan%2C+Roos%22">Kerklaan, Roos</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vlooswijk%2C+Carla%22">Vlooswijk, Carla</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bijlsma%2C+Rhodé+M%2E%22">Bijlsma, Rhodé M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaal%2C+Suzanne+E%2E+J%2E%22">Kaal, Suzanne E. J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tromp%2C+Jacqueline+M%2E%22">Tromp, Jacqueline M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bos%2C+Monique+E%2E+M%2E+M%2E%22">Bos, Monique E. M. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+der+Hulle%2C+Tom%22">van der Hulle, Tom</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Boer%2C+Maaike%22">de Boer, Maaike</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nuver%2C+Janine%22">Nuver, Janine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kouwenhoven%2C+Mathilde+C%2E+M%2E%22">Kouwenhoven, Mathilde C. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+der+Graaf%2C+Winette+T%2E+A%2E%22">van der Graaf, Winette T. A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Husson%2C+Olga%22">Husson, Olga</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. May2025, Vol. 34 Issue 5, p1483-1500. 18p.
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  Data: Purpose: As the prognosis for adolescents and young adults (AYAs) with breast cancer has improved, long-term health-related quality of life (HRQoL) has become increasingly important. This study aimed to analyze the long-term HRQoL of AYA breast cancer survivors compared to an age-matched normative population and to identify factors associated with HRQoL. Methods: Secondary analyses were conducted using data from the SURVAYA study. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30) was used to assess HRQoL. The Mann–Whitney U test was used to compare HRQoL scores of AYA breast cancer survivors with those of the normative population (n = 409). Linear regression models were constructed to identify patient and treatment characteristics associated with HRQoL. Results: A total of 944 female AYA breast cancer survivors were included, with a median age of 36.0 years and a median follow-up of 12.2 years. AYA breast cancer survivors scored significantly lower on five functional scales: physical, role, emotional, cognitive, and social, and higher on five symptom scales: fatigue, pain, dyspnea, insomnia, and financial impact compared to the normative population. Being in a relationship, having a positive body image, and adaptive coping were positively associated with HRQoL, while older age, chemotherapy, unemployment, and maladaptive coping were negatively associated. Conclusion: AYA breast cancer survivors experience significantly compromised long-term HRQoL compared to an age-matched normative population. These results highlight the need for tailored follow-up care and long-term support, as well as the importance of shared decision-making about the benefits and risks of treatments before initiation. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s11136-025-03914-1
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