View in EDS

Adaptive Functioning Development in Infants With Agenesis of the Corpus Callosum.

Saved in:
Bibliographic Details
Title: Adaptive Functioning Development in Infants With Agenesis of the Corpus Callosum.
Authors: Haisley, Lauren D., Hantzsch, Lana, Glick, Aaron R., Turner, Jasmin, Sung, Sooyeon, Swanson, Meghan R., Wolff, Jason J., Burrows, Catherine A., Botteron, Kelly N., Dager, Stephen R., Estes, Annette M., Flake, Lisa, McKinstry, Robert C., Pandey, Juhi, Schultz, Robert T., Shen, Mark D., John, Tanya St., Zwaigenbaum, Lonnie, Hazlett, Heather C., Marrus, Natasha
Source: Pediatrics. May2025, Vol. 155 Issue 5, p1-13. 1p.
Subjects: Parents, Statistical models, Motor ability, Child psychopathology, Infant development, Data analysis, Down syndrome, Research funding, Adaptability (Personality) in children, Autism, Questionnaires, Functional status, Descriptive statistics, Fragile X syndrome, Longitudinal method, Agenesis of corpus callosum, Child development, Statistics, Communication, Social skills, Asperger's syndrome, Activities of daily living, Socialization
Abstract: BACKGROUND AND OBJECTIVES: Agenesis of the corpus callosum (ACC) is a common congenital brain malformation. Early development in ACC remains unexamined, despite the increased likelihood for developmental delays and autistic behaviors. This study compares adaptive functioning in infants/toddlers with isolated ACC to children with other neurodevelopmental conditions and typical development. METHODS: Parents of children with ACC completed the Vineland Adaptive Behavior Scale Interview at 6, 12, 18, and 24 months as part of a prospective longitudinal study. Comparison groups included children with fragile X, Down syndrome, high familial likelihood of autism spectrum disorder (both with and without autism spectrum diagnosis), and typical development (total n = 957; total assessments = 2676). RESULTS: By 24 months, 29% of children with ACC were delayed in at least 1 domain. Linear mixed effect models showed significant group × time point interactions in all domains. Post-hoc comparisons revealed the ACC group had poorer performance in communication by 6, motor by 12, and daily living by 18 months but equivalent socialization compared with typically developing children; stronger skills across most domains and time points compared with genetic groups; and equivalent communication, stronger socialization, and weaker motor skills compared with the autism group. CONCLUSIONS: Although there is significant variability, on average, ACC compromises communication skills by 6 months, with reduced motor and daily living skills by 12 and 18 months, respectively. Multipronged intervention programs are needed for ACC beginning early in the first year of life, possibly leveraging early strengths in social skills. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 185098176
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Adaptive Functioning Development in Infants With Agenesis of the Corpus Callosum.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Haisley%2C+Lauren+D%2E%22">Haisley, Lauren D.</searchLink><br /><searchLink fieldCode="AR" term="%22Hantzsch%2C+Lana%22">Hantzsch, Lana</searchLink><br /><searchLink fieldCode="AR" term="%22Glick%2C+Aaron+R%2E%22">Glick, Aaron R.</searchLink><br /><searchLink fieldCode="AR" term="%22Turner%2C+Jasmin%22">Turner, Jasmin</searchLink><br /><searchLink fieldCode="AR" term="%22Sung%2C+Sooyeon%22">Sung, Sooyeon</searchLink><br /><searchLink fieldCode="AR" term="%22Swanson%2C+Meghan+R%2E%22">Swanson, Meghan R.</searchLink><br /><searchLink fieldCode="AR" term="%22Wolff%2C+Jason+J%2E%22">Wolff, Jason J.</searchLink><br /><searchLink fieldCode="AR" term="%22Burrows%2C+Catherine+A%2E%22">Burrows, Catherine A.</searchLink><br /><searchLink fieldCode="AR" term="%22Botteron%2C+Kelly+N%2E%22">Botteron, Kelly N.</searchLink><br /><searchLink fieldCode="AR" term="%22Dager%2C+Stephen+R%2E%22">Dager, Stephen R.</searchLink><br /><searchLink fieldCode="AR" term="%22Estes%2C+Annette+M%2E%22">Estes, Annette M.</searchLink><br /><searchLink fieldCode="AR" term="%22Flake%2C+Lisa%22">Flake, Lisa</searchLink><br /><searchLink fieldCode="AR" term="%22McKinstry%2C+Robert+C%2E%22">McKinstry, Robert C.</searchLink><br /><searchLink fieldCode="AR" term="%22Pandey%2C+Juhi%22">Pandey, Juhi</searchLink><br /><searchLink fieldCode="AR" term="%22Schultz%2C+Robert+T%2E%22">Schultz, Robert T.</searchLink><br /><searchLink fieldCode="AR" term="%22Shen%2C+Mark+D%2E%22">Shen, Mark D.</searchLink><br /><searchLink fieldCode="AR" term="%22John%2C+Tanya+St%2E%22">John, Tanya St.</searchLink><br /><searchLink fieldCode="AR" term="%22Zwaigenbaum%2C+Lonnie%22">Zwaigenbaum, Lonnie</searchLink><br /><searchLink fieldCode="AR" term="%22Hazlett%2C+Heather+C%2E%22">Hazlett, Heather C.</searchLink><br /><searchLink fieldCode="AR" term="%22Marrus%2C+Natasha%22">Marrus, Natasha</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. May2025, Vol. 155 Issue 5, p1-13. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Parents%22">Parents</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+models%22">Statistical models</searchLink><br /><searchLink fieldCode="DE" term="%22Motor+ability%22">Motor ability</searchLink><br /><searchLink fieldCode="DE" term="%22Child+psychopathology%22">Child psychopathology</searchLink><br /><searchLink fieldCode="DE" term="%22Infant+development%22">Infant development</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Down+syndrome%22">Down syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Adaptability+%28Personality%29+in+children%22">Adaptability (Personality) in children</searchLink><br /><searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+status%22">Functional status</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Fragile+X+syndrome%22">Fragile X syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Agenesis+of+corpus+callosum%22">Agenesis of corpus callosum</searchLink><br /><searchLink fieldCode="DE" term="%22Child+development%22">Child development</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Communication%22">Communication</searchLink><br /><searchLink fieldCode="DE" term="%22Social+skills%22">Social skills</searchLink><br /><searchLink fieldCode="DE" term="%22Asperger's+syndrome%22">Asperger's syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Activities+of+daily+living%22">Activities of daily living</searchLink><br /><searchLink fieldCode="DE" term="%22Socialization%22">Socialization</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND AND OBJECTIVES: Agenesis of the corpus callosum (ACC) is a common congenital brain malformation. Early development in ACC remains unexamined, despite the increased likelihood for developmental delays and autistic behaviors. This study compares adaptive functioning in infants/toddlers with isolated ACC to children with other neurodevelopmental conditions and typical development. METHODS: Parents of children with ACC completed the Vineland Adaptive Behavior Scale Interview at 6, 12, 18, and 24 months as part of a prospective longitudinal study. Comparison groups included children with fragile X, Down syndrome, high familial likelihood of autism spectrum disorder (both with and without autism spectrum diagnosis), and typical development (total n = 957; total assessments = 2676). RESULTS: By 24 months, 29% of children with ACC were delayed in at least 1 domain. Linear mixed effect models showed significant group × time point interactions in all domains. Post-hoc comparisons revealed the ACC group had poorer performance in communication by 6, motor by 12, and daily living by 18 months but equivalent socialization compared with typically developing children; stronger skills across most domains and time points compared with genetic groups; and equivalent communication, stronger socialization, and weaker motor skills compared with the autism group. CONCLUSIONS: Although there is significant variability, on average, ACC compromises communication skills by 6 months, with reduced motor and daily living skills by 12 and 18 months, respectively. Multipronged intervention programs are needed for ACC beginning early in the first year of life, possibly leveraging early strengths in social skills. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=185098176
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1542/peds.2024-066555
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: 1
    Subjects:
      – SubjectFull: Parents
        Type: general
      – SubjectFull: Statistical models
        Type: general
      – SubjectFull: Motor ability
        Type: general
      – SubjectFull: Child psychopathology
        Type: general
      – SubjectFull: Infant development
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Down syndrome
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Adaptability (Personality) in children
        Type: general
      – SubjectFull: Autism
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Functional status
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Fragile X syndrome
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Agenesis of corpus callosum
        Type: general
      – SubjectFull: Child development
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Communication
        Type: general
      – SubjectFull: Social skills
        Type: general
      – SubjectFull: Asperger's syndrome
        Type: general
      – SubjectFull: Activities of daily living
        Type: general
      – SubjectFull: Socialization
        Type: general
    Titles:
      – TitleFull: Adaptive Functioning Development in Infants With Agenesis of the Corpus Callosum.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Haisley, Lauren D.
      – PersonEntity:
          Name:
            NameFull: Hantzsch, Lana
      – PersonEntity:
          Name:
            NameFull: Glick, Aaron R.
      – PersonEntity:
          Name:
            NameFull: Turner, Jasmin
      – PersonEntity:
          Name:
            NameFull: Sung, Sooyeon
      – PersonEntity:
          Name:
            NameFull: Swanson, Meghan R.
      – PersonEntity:
          Name:
            NameFull: Wolff, Jason J.
      – PersonEntity:
          Name:
            NameFull: Burrows, Catherine A.
      – PersonEntity:
          Name:
            NameFull: Botteron, Kelly N.
      – PersonEntity:
          Name:
            NameFull: Dager, Stephen R.
      – PersonEntity:
          Name:
            NameFull: Estes, Annette M.
      – PersonEntity:
          Name:
            NameFull: Flake, Lisa
      – PersonEntity:
          Name:
            NameFull: McKinstry, Robert C.
      – PersonEntity:
          Name:
            NameFull: Pandey, Juhi
      – PersonEntity:
          Name:
            NameFull: Schultz, Robert T.
      – PersonEntity:
          Name:
            NameFull: Shen, Mark D.
      – PersonEntity:
          Name:
            NameFull: John, Tanya St.
      – PersonEntity:
          Name:
            NameFull: Zwaigenbaum, Lonnie
      – PersonEntity:
          Name:
            NameFull: Hazlett, Heather C.
      – PersonEntity:
          Name:
            NameFull: Marrus, Natasha
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 00314005
          Numbering:
            – Type: volume
              Value: 155
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Pediatrics
              Type: main
ResultId 1