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Consanguinity as a Risk Factor for Autism.

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Title: Consanguinity as a Risk Factor for Autism.
Authors: Alshaban, Fouad A., Aldosari, Mohammad, Ghazal, Iman, Al-Shammari, Hawraa, ElHag, Saba, Thompson, I. Richard, Bruder, Jennifer, Shaath, Hibah, Al-Faraj, Fatema, Tolefat, Mohamed, Nasir, Assal, Fombonne, Eric
Source: Journal of Autism & Developmental Disorders. Jun2025, Vol. 55 Issue 6, p1945-1952. 8p.
Subjects: Autism risk factors, Genetics of autism, Risk assessment, Research funding, Consanguinity, Questionnaires, Interviewing, Multiple regression analysis, Odds ratio, Case-control method, Asperger's syndrome, Confidence intervals
Geographic Terms: Qatar
Abstract: Purpose: Genetic and environmental risk factors associated with Autism Spectrum Disorders (ASD) continue to be a focus of research worldwide. Consanguinity, the cultural practice of marrying within a family, is common in cultures and societies of the Middle East, North Africa and parts of Asia. Consanguinity has been investigated as a risk factor for ASD in a limited number of studies, with mixed results. We employed registry and survey data from Qatar to evaluate the role of consanguinity as a risk factor for ASD. Methods: Data were sourced from a national registry and a population-based survey of autism recently conducted in Qatar. We selected a sample of 891 children (mean age: 8.3 years) with (N = 361) or without (N = 530) ASD. Data on consanguinity and covariates were collected through questionnaires and interviews. Results: The prevalence of consanguinity in the overall sample was 41.2% with no significant difference between cases and controls (42.1% vs 41.3%; p =.836). In adjusted multiple logistic regression analyses, consanguinity was not associated with risk of ASD (aOR = 1.065; 95% CI:.751-1.509; NS). Conclusion: Parental consanguinity was not associated with autism risk in our study. Replication in other populations with high rates of consanguineous unions is recommended. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Consanguinity as a Risk Factor for Autism.
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  Data: <searchLink fieldCode="AR" term="%22Alshaban%2C+Fouad+A%2E%22">Alshaban, Fouad A.</searchLink><br /><searchLink fieldCode="AR" term="%22Aldosari%2C+Mohammad%22">Aldosari, Mohammad</searchLink><br /><searchLink fieldCode="AR" term="%22Ghazal%2C+Iman%22">Ghazal, Iman</searchLink><br /><searchLink fieldCode="AR" term="%22Al-Shammari%2C+Hawraa%22">Al-Shammari, Hawraa</searchLink><br /><searchLink fieldCode="AR" term="%22ElHag%2C+Saba%22">ElHag, Saba</searchLink><br /><searchLink fieldCode="AR" term="%22Thompson%2C+I%2E+Richard%22">Thompson, I. Richard</searchLink><br /><searchLink fieldCode="AR" term="%22Bruder%2C+Jennifer%22">Bruder, Jennifer</searchLink><br /><searchLink fieldCode="AR" term="%22Shaath%2C+Hibah%22">Shaath, Hibah</searchLink><br /><searchLink fieldCode="AR" term="%22Al-Faraj%2C+Fatema%22">Al-Faraj, Fatema</searchLink><br /><searchLink fieldCode="AR" term="%22Tolefat%2C+Mohamed%22">Tolefat, Mohamed</searchLink><br /><searchLink fieldCode="AR" term="%22Nasir%2C+Assal%22">Nasir, Assal</searchLink><br /><searchLink fieldCode="AR" term="%22Fombonne%2C+Eric%22">Fombonne, Eric</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Jun2025, Vol. 55 Issue 6, p1945-1952. 8p.
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  Data: Purpose: Genetic and environmental risk factors associated with Autism Spectrum Disorders (ASD) continue to be a focus of research worldwide. Consanguinity, the cultural practice of marrying within a family, is common in cultures and societies of the Middle East, North Africa and parts of Asia. Consanguinity has been investigated as a risk factor for ASD in a limited number of studies, with mixed results. We employed registry and survey data from Qatar to evaluate the role of consanguinity as a risk factor for ASD. Methods: Data were sourced from a national registry and a population-based survey of autism recently conducted in Qatar. We selected a sample of 891 children (mean age: 8.3 years) with (N = 361) or without (N = 530) ASD. Data on consanguinity and covariates were collected through questionnaires and interviews. Results: The prevalence of consanguinity in the overall sample was 41.2% with no significant difference between cases and controls (42.1% vs 41.3%; p =.836). In adjusted multiple logistic regression analyses, consanguinity was not associated with risk of ASD (aOR = 1.065; 95% CI:.751-1.509; NS). Conclusion: Parental consanguinity was not associated with autism risk in our study. Replication in other populations with high rates of consanguineous unions is recommended. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=185099700
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        Value: 10.1007/s10803-023-06137-w
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 1945
    Subjects:
      – SubjectFull: Autism risk factors
        Type: general
      – SubjectFull: Genetics of autism
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      – SubjectFull: Risk assessment
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      – SubjectFull: Research funding
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      – SubjectFull: Consanguinity
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      – SubjectFull: Interviewing
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      – SubjectFull: Qatar
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