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Genotype-dependent functional role of the anterior and posterior paraventricular thalamus in pavlovian conditioned approach.

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Title: Genotype-dependent functional role of the anterior and posterior paraventricular thalamus in pavlovian conditioned approach.
Authors: Tarmati, Valeria (AUTHOR), Sepe, Andrea (AUTHOR), Accoto, Alessandra (AUTHOR), Conversi, David (AUTHOR), Laricchiuta, Daniela (AUTHOR), Panuccio, Anna (AUTHOR), Canterini, Sonia (AUTHOR), Fiorenza, Maria Teresa (AUTHOR), Cabib, Simona (AUTHOR), Orsini, Cristina (AUTHOR)
Source: Psychopharmacology. Jun2025, Vol. 242 Issue 6, p1275-1289. 15p.
Subjects: Paraventricular nucleus, Genotypes, Cell populations, Laboratory mice, Classical conditioning, Stimulus & response (Psychology), Dopamine receptors
Abstract: Rationale: The specific location of deviations from normative models of brain function varies considerably across individuals with the same diagnoses. However, as pathological processes are distributed across interconnected systems, this heterogeneity of individual brain deviations may also reveal similarities and differences between disorders. The paraventricular nucleus of the thalamus (PVT) is a potential switcher to various behavioral responses where functionally distinct cell types exist across its antero-posterior axis. Objectives: This study aimed to test the hypothesis that genotype-dependent differences in the anterior and posterior PVT subregions (aPVT and pPVT) are involved in the Sign-tracking (ST) behavior expressed by C57BL/6J (C57) and DBA/2J (DBA) inbred mice. Methods: Based on previous findings, male mice of the two strains were tested at ten weeks of age. The density of c-Fos immunoreactivity along the antero-posterior axis of PVT was assessed following the expression of ST behavior. Selective excitotoxic lesions of the aPVT or the pPVT by the NMDA infusion were performed prior to development of ST behavior. Finally, the distribution of neuronal populations expressing the Drd2 and Gal genes (D2R + and Gal +) was measured by in situ hybridization (ISH). Results: The involvement of PVT subregions in ST behavior is strain-specific, as aPVT is crucial for ST acquisition in DBA mice while pPVT is crucial for C57 mice. Despite similar antero-posterior distribution of D2R + and Gal + neurons, density of D2R + neurons differentiate aPVT in C57 and DBA mice. Conclusions: These genotype-dependent results offer valuable insights into the nuanced organization of brain networks and individual variability in behavioral responses. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Genotype-dependent functional role of the anterior and posterior paraventricular thalamus in pavlovian conditioned approach.
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  Data: <searchLink fieldCode="AR" term="%22Tarmati%2C+Valeria%22">Tarmati, Valeria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sepe%2C+Andrea%22">Sepe, Andrea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Accoto%2C+Alessandra%22">Accoto, Alessandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Conversi%2C+David%22">Conversi, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Laricchiuta%2C+Daniela%22">Laricchiuta, Daniela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Panuccio%2C+Anna%22">Panuccio, Anna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Canterini%2C+Sonia%22">Canterini, Sonia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fiorenza%2C+Maria+Teresa%22">Fiorenza, Maria Teresa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cabib%2C+Simona%22">Cabib, Simona</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Orsini%2C+Cristina%22">Orsini, Cristina</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jun2025, Vol. 242 Issue 6, p1275-1289. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Paraventricular+nucleus%22">Paraventricular nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+populations%22">Cell populations</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Classical+conditioning%22">Classical conditioning</searchLink><br /><searchLink fieldCode="DE" term="%22Stimulus+%26+response+%28Psychology%29%22">Stimulus & response (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine+receptors%22">Dopamine receptors</searchLink>
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  Data: Rationale: The specific location of deviations from normative models of brain function varies considerably across individuals with the same diagnoses. However, as pathological processes are distributed across interconnected systems, this heterogeneity of individual brain deviations may also reveal similarities and differences between disorders. The paraventricular nucleus of the thalamus (PVT) is a potential switcher to various behavioral responses where functionally distinct cell types exist across its antero-posterior axis. Objectives: This study aimed to test the hypothesis that genotype-dependent differences in the anterior and posterior PVT subregions (aPVT and pPVT) are involved in the Sign-tracking (ST) behavior expressed by C57BL/6J (C57) and DBA/2J (DBA) inbred mice. Methods: Based on previous findings, male mice of the two strains were tested at ten weeks of age. The density of c-Fos immunoreactivity along the antero-posterior axis of PVT was assessed following the expression of ST behavior. Selective excitotoxic lesions of the aPVT or the pPVT by the NMDA infusion were performed prior to development of ST behavior. Finally, the distribution of neuronal populations expressing the Drd2 and Gal genes (D2R + and Gal +) was measured by in situ hybridization (ISH). Results: The involvement of PVT subregions in ST behavior is strain-specific, as aPVT is crucial for ST acquisition in DBA mice while pPVT is crucial for C57 mice. Despite similar antero-posterior distribution of D2R + and Gal + neurons, density of D2R + neurons differentiate aPVT in C57 and DBA mice. Conclusions: These genotype-dependent results offer valuable insights into the nuanced organization of brain networks and individual variability in behavioral responses. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jun2025
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