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Theory of Mind in Myotonic Dystrophy Type 1 Is Associated With Cortical Gyrification and White Matter Hyperintensities.

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Title: Theory of Mind in Myotonic Dystrophy Type 1 Is Associated With Cortical Gyrification and White Matter Hyperintensities.
Authors: Davion, Jean‐Baptiste (AUTHOR), Tard, Céline (AUTHOR), Viard, Romain (AUTHOR), Fragoso, Loren (AUTHOR), Wilu‐Wilu, Amina (AUTHOR), Defebvre, Luc (AUTHOR), Kuchcinski, Grégory (AUTHOR), Delbeuck, Xavier (AUTHOR)
Source: European Journal of Neurology. May2025, Vol. 32 Issue 5, p1-10. 10p.
Subjects: Theory of mind, White matter (Nerve tissue), Emotion recognition, Myotonia atrophica, Neural pathways, Neuroanatomy, Perspective taking, Magnetic resonance imaging
Abstract: Background: Theory of Mind (ToM) Refers to the ability to infer other people's thoughts (Cognitive ToM) and emotions (Affective ToM). Myotonic Dystrophy Type 1 (DM1) Patients Showed an impairment of ToM capacities, but the underlying neural mechanisms remain poorly understood. Methods: We included 58 adult non‐congenital DM1 patients from the DMVASCOG cohort, who underwent a ToM evaluation using the Movie for the Assessment of Social Cognition and a brain MRI. Association of ToM scores with cortical thickness and gyrification was assessed using FreeSurfer software, and associations with white matter hyperintensities were assessed using SVR‐LSM. Finally, we included all the significantly associated parameters in a multivariate model. Results: The ToM total score and cognitive subscore were both associated with the local gyrification in the right superior parietal gyrus and with the hyperintensities in the bilateral temporopolar white matter. The ToM total score was also associated with hyperintensities in the bilateral temporo‐parietal and left frontal white matter. Multivariate models based on these parameters allowed a better prediction of the ToM total score (R2 = 0.49) and cognitive subscore (R2 = 0.52) than univariate models. There was no association between ToM measures and cortical thickness, nor between brain MRI measures and affective subscore/error types. Conclusions: The ToM cognitive involvement in DM1 is associated with both the gyrification in the right superior parietal gyrus and the volume of hyperintensities in the anterior‐temporal white matter, suggesting the possible joint implication of a neurodevelopmental phenomenon and disconnections arising from white matter changes. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Theory of Mind in Myotonic Dystrophy Type 1 Is Associated With Cortical Gyrification and White Matter Hyperintensities.
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  Data: <searchLink fieldCode="AR" term="%22Davion%2C+Jean‐Baptiste%22">Davion, Jean‐Baptiste</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tard%2C+Céline%22">Tard, Céline</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Viard%2C+Romain%22">Viard, Romain</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fragoso%2C+Loren%22">Fragoso, Loren</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wilu‐Wilu%2C+Amina%22">Wilu‐Wilu, Amina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Defebvre%2C+Luc%22">Defebvre, Luc</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kuchcinski%2C+Grégory%22">Kuchcinski, Grégory</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Delbeuck%2C+Xavier%22">Delbeuck, Xavier</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. May2025, Vol. 32 Issue 5, p1-10. 10p.
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  Data: Background: Theory of Mind (ToM) Refers to the ability to infer other people's thoughts (Cognitive ToM) and emotions (Affective ToM). Myotonic Dystrophy Type 1 (DM1) Patients Showed an impairment of ToM capacities, but the underlying neural mechanisms remain poorly understood. Methods: We included 58 adult non‐congenital DM1 patients from the DMVASCOG cohort, who underwent a ToM evaluation using the Movie for the Assessment of Social Cognition and a brain MRI. Association of ToM scores with cortical thickness and gyrification was assessed using FreeSurfer software, and associations with white matter hyperintensities were assessed using SVR‐LSM. Finally, we included all the significantly associated parameters in a multivariate model. Results: The ToM total score and cognitive subscore were both associated with the local gyrification in the right superior parietal gyrus and with the hyperintensities in the bilateral temporopolar white matter. The ToM total score was also associated with hyperintensities in the bilateral temporo‐parietal and left frontal white matter. Multivariate models based on these parameters allowed a better prediction of the ToM total score (R2 = 0.49) and cognitive subscore (R2 = 0.52) than univariate models. There was no association between ToM measures and cortical thickness, nor between brain MRI measures and affective subscore/error types. Conclusions: The ToM cognitive involvement in DM1 is associated with both the gyrification in the right superior parietal gyrus and the volume of hyperintensities in the anterior‐temporal white matter, suggesting the possible joint implication of a neurodevelopmental phenomenon and disconnections arising from white matter changes. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Neural pathways
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      – SubjectFull: Neuroanatomy
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      – SubjectFull: Perspective taking
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      – SubjectFull: Magnetic resonance imaging
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              M: 05
              Text: May2025
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              Y: 2025
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