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Sex differences in anhedonia in bipolar depression: a resting-state fMRI study.

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Title: Sex differences in anhedonia in bipolar depression: a resting-state fMRI study.
Authors: Wang, Xiaoqin (AUTHOR), Xia, Yi (AUTHOR), Yan, Rui (AUTHOR), Sun, Hao (AUTHOR), Huang, Yinghong (AUTHOR), Xia, Qiudong (AUTHOR), Sheng, Junling (AUTHOR), You, Wei (AUTHOR), Hua, Lingling (AUTHOR), Tang, Hao (AUTHOR), Yao, Zhijian (AUTHOR), Lu, Qing (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Jun2025, Vol. 275 Issue 4, p1087-1097. 11p.
Subjects: Anhedonia, Gender differences (Psychology), Cognition, Gender, Functional magnetic resonance imaging, Brain imaging, Bipolar disorder
Abstract: Previous studies about anhedonia symptoms in bipolar depression (BD) ignored the unique role of gender on brain function. This study aims to explore the regional brain neuroimaging features of BD with anhedonia and the sex differences in these patients. The resting-fMRI by applying fractional amplitude of low-frequency fluctuation (fALFF) method was estimated in 263 patients with BD (174 high anhedonia [HA], 89 low anhedonia [LA]) and 213 healthy controls. The effects of two different factors in patients with BD were analyzed using a 3 (group: HA, LA, HC) × 2 (sex: male, female) ANOVA. The fALFF values were higher in the HA group than in the LA group in the right medial cingulate gyrus and supplementary motor area. For the sex-by-group interaction, the fALFF values of the right hippocampus, left medial occipital gyrus, right insula, and bilateral medial cingulate gyrus were significantly higher in HA males than in LA males but not females. These results suggested that the pattern of high activation could be a marker of anhedonia symptoms in BD males, and the sex differences should be considered in future studies of BD with anhedonia symptoms. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Sex differences in anhedonia in bipolar depression: a resting-state fMRI study.
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Xiaoqin%22">Wang, Xiaoqin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xia%2C+Yi%22">Xia, Yi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yan%2C+Rui%22">Yan, Rui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Hao%22">Sun, Hao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Yinghong%22">Huang, Yinghong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xia%2C+Qiudong%22">Xia, Qiudong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sheng%2C+Junling%22">Sheng, Junling</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22You%2C+Wei%22">You, Wei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hua%2C+Lingling%22">Hua, Lingling</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Hao%22">Tang, Hao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yao%2C+Zhijian%22">Yao, Zhijian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Qing%22">Lu, Qing</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Jun2025, Vol. 275 Issue 4, p1087-1097. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Anhedonia%22">Anhedonia</searchLink><br /><searchLink fieldCode="DE" term="%22Gender+differences+%28Psychology%29%22">Gender differences (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Gender%22">Gender</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink>
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  Data: Previous studies about anhedonia symptoms in bipolar depression (BD) ignored the unique role of gender on brain function. This study aims to explore the regional brain neuroimaging features of BD with anhedonia and the sex differences in these patients. The resting-fMRI by applying fractional amplitude of low-frequency fluctuation (fALFF) method was estimated in 263 patients with BD (174 high anhedonia [HA], 89 low anhedonia [LA]) and 213 healthy controls. The effects of two different factors in patients with BD were analyzed using a 3 (group: HA, LA, HC) × 2 (sex: male, female) ANOVA. The fALFF values were higher in the HA group than in the LA group in the right medial cingulate gyrus and supplementary motor area. For the sex-by-group interaction, the fALFF values of the right hippocampus, left medial occipital gyrus, right insula, and bilateral medial cingulate gyrus were significantly higher in HA males than in LA males but not females. These results suggested that the pattern of high activation could be a marker of anhedonia symptoms in BD males, and the sex differences should be considered in future studies of BD with anhedonia symptoms. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=185809794
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        Type: general
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              Text: Jun2025
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