View in EDS HTML Full Text PDF Full Text

Hippocampal, thalamic, and amygdala subfield morphology in major depressive disorder: an ultra-high resolution MRI study at 7-Tesla.

Saved in:
Bibliographic Details
Title: Hippocampal, thalamic, and amygdala subfield morphology in major depressive disorder: an ultra-high resolution MRI study at 7-Tesla.
Authors: Liu, Weijian (AUTHOR), Heij, Jurjen (AUTHOR), Liu, Shu (AUTHOR), Liebrand, Luka (AUTHOR), Caan, Matthan (AUTHOR), van der Zwaag, Wietske (AUTHOR), Veltman, Dick J. (AUTHOR), Lu, Lin (AUTHOR), Aghajani, Moji (AUTHOR), van Wingen, Guido (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Jun2025, Vol. 275 Issue 4, p1113-1129. 17p.
Subjects: Hippocampus (Brain), Mental depression, Amygdaloid body, Magnetic resonance imaging, Symptoms
Abstract: Morphological changes in the hippocampal, thalamic, and amygdala subfields have been suggested to form part of the pathophysiology of major depressive disorder (MDD). However, the use of conventional MRI scanners and acquisition techniques has prevented in-depth examinations at the subfield level, precluding a fine-grained understanding of these subfields and their involvement in MDD pathophysiology. We uniquely employed ultra-high field MRI at 7.0 Tesla to map hippocampal, thalamic, and amygdala subfields in MDD. Fifty-six MDD patients and 14 healthy controls (HCs) were enrolled in the final analysis. FreeSurfer protocols were used to segment hippocampal, thalamic, and amygdala subfields. Bayesian analysis was then implemented to assess differences between groups and relations with clinical features. While no effect was found for MDD diagnosis (i.e., case–control comparison), clinical characteristics of MDD patients were associated with subfield volumes of the hippocampus, thalamus, and amygdala. Specifically, the severity of depressive symptoms, insomnia, and childhood trauma in MDD patients related to lower thalamic subfield volumes. In addition, MDD patients with typical MDD versus those with atypical MDD showed lower hippocampal, thalamic, and amygdala subfield volumes. MDD patients with recurrent MDD versus those with first-episode MDD also showed lower thalamic subfield volumes. These findings allow uniquely fine-grained insights into hippocampal, thalamic, and amygdala subfield morphology in MDD, linking some of them to the clinical manifestation of MDD. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 185809807
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Hippocampal, thalamic, and amygdala subfield morphology in major depressive disorder: an ultra-high resolution MRI study at 7-Tesla.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Liu%2C+Weijian%22">Liu, Weijian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heij%2C+Jurjen%22">Heij, Jurjen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Shu%22">Liu, Shu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liebrand%2C+Luka%22">Liebrand, Luka</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Caan%2C+Matthan%22">Caan, Matthan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+der+Zwaag%2C+Wietske%22">van der Zwaag, Wietske</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Veltman%2C+Dick+J%2E%22">Veltman, Dick J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Lin%22">Lu, Lin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aghajani%2C+Moji%22">Aghajani, Moji</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Wingen%2C+Guido%22">van Wingen, Guido</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Jun2025, Vol. 275 Issue 4, p1113-1129. 17p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Morphological changes in the hippocampal, thalamic, and amygdala subfields have been suggested to form part of the pathophysiology of major depressive disorder (MDD). However, the use of conventional MRI scanners and acquisition techniques has prevented in-depth examinations at the subfield level, precluding a fine-grained understanding of these subfields and their involvement in MDD pathophysiology. We uniquely employed ultra-high field MRI at 7.0 Tesla to map hippocampal, thalamic, and amygdala subfields in MDD. Fifty-six MDD patients and 14 healthy controls (HCs) were enrolled in the final analysis. FreeSurfer protocols were used to segment hippocampal, thalamic, and amygdala subfields. Bayesian analysis was then implemented to assess differences between groups and relations with clinical features. While no effect was found for MDD diagnosis (i.e., case–control comparison), clinical characteristics of MDD patients were associated with subfield volumes of the hippocampus, thalamus, and amygdala. Specifically, the severity of depressive symptoms, insomnia, and childhood trauma in MDD patients related to lower thalamic subfield volumes. In addition, MDD patients with typical MDD versus those with atypical MDD showed lower hippocampal, thalamic, and amygdala subfield volumes. MDD patients with recurrent MDD versus those with first-episode MDD also showed lower thalamic subfield volumes. These findings allow uniquely fine-grained insights into hippocampal, thalamic, and amygdala subfield morphology in MDD, linking some of them to the clinical manifestation of MDD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=185809807
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00406-024-01874-0
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 17
        StartPage: 1113
    Subjects:
      – SubjectFull: Hippocampus (Brain)
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Amygdaloid body
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Symptoms
        Type: general
    Titles:
      – TitleFull: Hippocampal, thalamic, and amygdala subfield morphology in major depressive disorder: an ultra-high resolution MRI study at 7-Tesla.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Liu, Weijian
      – PersonEntity:
          Name:
            NameFull: Heij, Jurjen
      – PersonEntity:
          Name:
            NameFull: Liu, Shu
      – PersonEntity:
          Name:
            NameFull: Liebrand, Luka
      – PersonEntity:
          Name:
            NameFull: Caan, Matthan
      – PersonEntity:
          Name:
            NameFull: van der Zwaag, Wietske
      – PersonEntity:
          Name:
            NameFull: Veltman, Dick J.
      – PersonEntity:
          Name:
            NameFull: Lu, Lin
      – PersonEntity:
          Name:
            NameFull: Aghajani, Moji
      – PersonEntity:
          Name:
            NameFull: van Wingen, Guido
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 09401334
          Numbering:
            – Type: volume
              Value: 275
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: European Archives of Psychiatry & Clinical Neuroscience
              Type: main
ResultId 1