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Longitudinal associations between depressive symptoms and cell deformability: do glucocorticoids play a role?

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Title: Longitudinal associations between depressive symptoms and cell deformability: do glucocorticoids play a role?
Authors: Eder, Julian (AUTHOR), Kräter, Martin (AUTHOR), Kirschbaum, Clemens (AUTHOR), Gao, Wei (AUTHOR), Wekenborg, Magdalena (AUTHOR), Penz, Marlene (AUTHOR), Rothe, Nicole (AUTHOR), Guck, Jochen (AUTHOR), Wittwer, Lucas Daniel (AUTHOR), Walther, Andreas (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Jun2025, Vol. 275 Issue 4, p1075-1085. 11p.
Subjects: Mental depression, Glucocorticoids, Monocytes, Hydrocortisone, Longitudinal method, Cellular mechanics, Cellular immunity
Abstract: Cell deformability of all major blood cell types is increased in depressive disorders (DD). Furthermore, impaired glucocorticoid secretion is associated with DD, as well as depressive symptoms in general and known to alter cell mechanical properties. Nevertheless, there are no longitudinal studies examining accumulated glucocorticoid output and depressive symptoms regarding cell deformability. The aim of the present study was to investigate, whether depressive symptoms predict cell deformability one year later and whether accumulated hair glucocorticoids mediate this relationship. In 136 individuals (nfemale = 100; Mage = 46.72, SD = 11.28; age range = 20–65), depressive symptoms (PHQ-9) and hair glucocorticoids (cortisol and cortisone) were measured at time point one (T1), while one year later (T2) both depressive symptoms and hair glucocorticoids were reassessed. Additionally, cell deformability of peripheral blood cells was assessed at T2. Depression severity at T1 predicted higher cell deformability in monocytes and lymphocytes at T2. Accumulated hair cortisol and cortisone concentrations from T1 and T2 were not associated with higher cell deformability and further did not mediate the relationship between depressive symptoms and cell deformability. Elevated depressive symptomatology in a population based sample is longitudinally associated with higher immune cell deformability, while long-term integrated glucocorticoid levels seem not to be implicated in the underlying mechanism. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Longitudinal associations between depressive symptoms and cell deformability: do glucocorticoids play a role?
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  Data: <searchLink fieldCode="AR" term="%22Eder%2C+Julian%22">Eder, Julian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kräter%2C+Martin%22">Kräter, Martin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kirschbaum%2C+Clemens%22">Kirschbaum, Clemens</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gao%2C+Wei%22">Gao, Wei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wekenborg%2C+Magdalena%22">Wekenborg, Magdalena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Penz%2C+Marlene%22">Penz, Marlene</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rothe%2C+Nicole%22">Rothe, Nicole</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guck%2C+Jochen%22">Guck, Jochen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wittwer%2C+Lucas+Daniel%22">Wittwer, Lucas Daniel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Walther%2C+Andreas%22">Walther, Andreas</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Jun2025, Vol. 275 Issue 4, p1075-1085. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Glucocorticoids%22">Glucocorticoids</searchLink><br /><searchLink fieldCode="DE" term="%22Monocytes%22">Monocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrocortisone%22">Hydrocortisone</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+mechanics%22">Cellular mechanics</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+immunity%22">Cellular immunity</searchLink>
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  Data: Cell deformability of all major blood cell types is increased in depressive disorders (DD). Furthermore, impaired glucocorticoid secretion is associated with DD, as well as depressive symptoms in general and known to alter cell mechanical properties. Nevertheless, there are no longitudinal studies examining accumulated glucocorticoid output and depressive symptoms regarding cell deformability. The aim of the present study was to investigate, whether depressive symptoms predict cell deformability one year later and whether accumulated hair glucocorticoids mediate this relationship. In 136 individuals (nfemale = 100; Mage = 46.72, SD = 11.28; age range = 20–65), depressive symptoms (PHQ-9) and hair glucocorticoids (cortisol and cortisone) were measured at time point one (T1), while one year later (T2) both depressive symptoms and hair glucocorticoids were reassessed. Additionally, cell deformability of peripheral blood cells was assessed at T2. Depression severity at T1 predicted higher cell deformability in monocytes and lymphocytes at T2. Accumulated hair cortisol and cortisone concentrations from T1 and T2 were not associated with higher cell deformability and further did not mediate the relationship between depressive symptoms and cell deformability. Elevated depressive symptomatology in a population based sample is longitudinally associated with higher immune cell deformability, while long-term integrated glucocorticoid levels seem not to be implicated in the underlying mechanism. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Cellular mechanics
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              Text: Jun2025
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