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Changes in retinal and choroidal thickness and blood density in participants with keratoconus.

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Title: Changes in retinal and choroidal thickness and blood density in participants with keratoconus.
Authors: Sun, Bingqing (AUTHOR), Xian, Yiyong (AUTHOR), Yang, Dongmei (AUTHOR), Hu, Xiaojun (AUTHOR), Wang, Jifang (AUTHOR), Sun, Ling (AUTHOR), Shen, Yang (AUTHOR), Zhou, Xingtao (AUTHOR), Zhang, Xiaoyu (AUTHOR)
Source: Ophthalmic & Physiological Optics. Jul2025, Vol. 45 Issue 5, p1201-1210. 10p.
Subjects: Keratoconus, Choroid, Myopia, Corneal topography, Vision disorders, Pathological physiology
Abstract: Purpose: Keratoconus causes progressive myopia and irregular astigmatism, leading to vision impairment. This study investigated choroidal and retinal variations and their influence in participants with keratoconus. Methods: This case–control study assessed 33 keratoconic and 33 axial length‐matched healthy myopic eyes. Choroidal and retinal parameters between the two groups were compared using general linear models. Correlations between keratoconus choroidal/retinal parameters and ABCD grading or tomographic keratoconus classification (TKC) staging were assessed. Multivariable linear regression models were used to investigate the factors affecting changes in keratoconus choroidal/retinal thickness and blood flow. Results: Keratoconus participants exhibited 2.3% lower macular inner retinal thickness (mean difference: −4.97 μm, p = 0.02), along with 8.0% and 2.3% higher superior and mean retinal vessel (mean difference: 2.71%, p = 0.03; mean difference: 3.22%, p = 0.01) densities, respectively, compared with controls. The blood flow density of the choroidal capillaries was 15.5% higher (mean difference: 5.72%, p = 0.01), while the large choroidal vessel density was 4.8% lower (mean difference: −3.38%, p = 0.03) at the macula in the keratoconus group. In the keratoconus group, higher deep retinal vessel density correlated with more severe A grading (r = 0.49, p = 0.006), while lower large choroidal vessel density correlated with more severe B grading (r = −0.48, p = 0.006); notably, higher deep retinal vessel density was positively correlated with more severe TKC staging (r = 0.50, p = 0.004). Furthermore, superior retinal vessel density was associated with the index of vertical asymmetry (IVA) (slope coefficient: 3.55%, p = 0.03) and the index of height asymmetry (slope coefficient: 0.07%, p = 0.04). Mean retinal vessel density was associated with IVA (slope coefficient: 4.82%, p = 0.01). Choroidal capillary density was associated with the keratoconus index (slope coefficient: 21.89%, p = 0.01). Large choroidal vessel density was associated with the steepest keratometry (slope coefficient: −0.61%/D, p = 0.009). Conclusion: Participants with keratoconus exhibited choroidal and retinal parameter alterations associated with keratoconus severity, as well as corneal keratometry and irregularity, suggesting the potential pathophysiological mechanisms. [ABSTRACT FROM AUTHOR]
Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Changes in retinal and choroidal thickness and blood density in participants with keratoconus.
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  Data: <searchLink fieldCode="AR" term="%22Sun%2C+Bingqing%22">Sun, Bingqing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xian%2C+Yiyong%22">Xian, Yiyong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Dongmei%22">Yang, Dongmei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Xiaojun%22">Hu, Xiaojun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jifang%22">Wang, Jifang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Ling%22">Sun, Ling</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shen%2C+Yang%22">Shen, Yang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Xingtao%22">Zhou, Xingtao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xiaoyu%22">Zhang, Xiaoyu</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Ophthalmic+%26+Physiological+Optics%22">Ophthalmic & Physiological Optics</searchLink>. Jul2025, Vol. 45 Issue 5, p1201-1210. 10p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Keratoconus%22">Keratoconus</searchLink><br /><searchLink fieldCode="DE" term="%22Choroid%22">Choroid</searchLink><br /><searchLink fieldCode="DE" term="%22Myopia%22">Myopia</searchLink><br /><searchLink fieldCode="DE" term="%22Corneal+topography%22">Corneal topography</searchLink><br /><searchLink fieldCode="DE" term="%22Vision+disorders%22">Vision disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+physiology%22">Pathological physiology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: Keratoconus causes progressive myopia and irregular astigmatism, leading to vision impairment. This study investigated choroidal and retinal variations and their influence in participants with keratoconus. Methods: This case–control study assessed 33 keratoconic and 33 axial length‐matched healthy myopic eyes. Choroidal and retinal parameters between the two groups were compared using general linear models. Correlations between keratoconus choroidal/retinal parameters and ABCD grading or tomographic keratoconus classification (TKC) staging were assessed. Multivariable linear regression models were used to investigate the factors affecting changes in keratoconus choroidal/retinal thickness and blood flow. Results: Keratoconus participants exhibited 2.3% lower macular inner retinal thickness (mean difference: −4.97 μm, p = 0.02), along with 8.0% and 2.3% higher superior and mean retinal vessel (mean difference: 2.71%, p = 0.03; mean difference: 3.22%, p = 0.01) densities, respectively, compared with controls. The blood flow density of the choroidal capillaries was 15.5% higher (mean difference: 5.72%, p = 0.01), while the large choroidal vessel density was 4.8% lower (mean difference: −3.38%, p = 0.03) at the macula in the keratoconus group. In the keratoconus group, higher deep retinal vessel density correlated with more severe A grading (r = 0.49, p = 0.006), while lower large choroidal vessel density correlated with more severe B grading (r = −0.48, p = 0.006); notably, higher deep retinal vessel density was positively correlated with more severe TKC staging (r = 0.50, p = 0.004). Furthermore, superior retinal vessel density was associated with the index of vertical asymmetry (IVA) (slope coefficient: 3.55%, p = 0.03) and the index of height asymmetry (slope coefficient: 0.07%, p = 0.04). Mean retinal vessel density was associated with IVA (slope coefficient: 4.82%, p = 0.01). Choroidal capillary density was associated with the keratoconus index (slope coefficient: 21.89%, p = 0.01). Large choroidal vessel density was associated with the steepest keratometry (slope coefficient: −0.61%/D, p = 0.009). Conclusion: Participants with keratoconus exhibited choroidal and retinal parameter alterations associated with keratoconus severity, as well as corneal keratometry and irregularity, suggesting the potential pathophysiological mechanisms. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1111/opo.13511
    Languages:
      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 1201
    Subjects:
      – SubjectFull: Keratoconus
        Type: general
      – SubjectFull: Choroid
        Type: general
      – SubjectFull: Myopia
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      – SubjectFull: Corneal topography
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      – SubjectFull: Vision disorders
        Type: general
      – SubjectFull: Pathological physiology
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      – TitleFull: Changes in retinal and choroidal thickness and blood density in participants with keratoconus.
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              M: 07
              Text: Jul2025
              Type: published
              Y: 2025
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