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Oxytocin Amplifies Negative Response to Ambiguity in Adolescent Females With and Without Eating Disorders.

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Title: Oxytocin Amplifies Negative Response to Ambiguity in Adolescent Females With and Without Eating Disorders.
Authors: Burmester, Victoria (AUTHOR), Sheridan, Emerie (AUTHOR), Julius, Nikita Catalina (AUTHOR), Elliott, Jordan (AUTHOR), Thackeray, Olivia (AUTHOR), Nicholls, Dasha (AUTHOR)
Source: European Eating Disorders Review. Jul2025, Vol. 33 Issue 4, p691-699. 9p.
Subjects: Oxytocin, Intranasal administration, Research funding, Statistical sampling, Blind experiment, Treatment effectiveness, Randomized controlled trials, Eating disorders, Crossover trials, Communication, Comparative studies, Adolescence
Abstract: Objective: Eating disorders (ED) typically emerge in adolescence, a critical period for brain development and peer bonding. Interpersonal difficulties—particularly social anxiety—frequently co‐occur with ED. Oxytocin is a neuropeptide that modulates social cognition and linked to prosocial effects. To date, no study has investigated oxytocin's effects on negative interpretation bias toward ambiguous information in adolescents with ED. Methods: Forty‐eight female adolescents aged 16 to 17 years with and without EDs took part in a placebo‐controlled, double‐blinded, randomised, crossover trial investigating the effects of 24 IU intranasal oxytocin on negative interpretations of ambiguous scenarios. Participants and controls were tested twice, approximately one week apart. Results: Contrary to hypothesis, oxytocin increased negative interpretations overall (p = 0.019, large effect). Adolescent females with AN or BN made more negative interpretations than controls when presented with ambiguous information. There was no group effect for those who reached or did not reach threshold on an autism screen. Conclusions: This study suggests adolescents with EDs interpret ambiguous information more negatively than controls and that oxytocin administration amplifies negative responses to ambiguity in adolescent females, including in controls. Research tools that effectively identify these biases would help to widen the scope of ED treatments for adolescents. [ABSTRACT FROM AUTHOR]
Copyright of European Eating Disorders Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Oxytocin Amplifies Negative Response to Ambiguity in Adolescent Females With and Without Eating Disorders.
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  Data: <searchLink fieldCode="AR" term="%22Burmester%2C+Victoria%22">Burmester, Victoria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sheridan%2C+Emerie%22">Sheridan, Emerie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Julius%2C+Nikita+Catalina%22">Julius, Nikita Catalina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Elliott%2C+Jordan%22">Elliott, Jordan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thackeray%2C+Olivia%22">Thackeray, Olivia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nicholls%2C+Dasha%22">Nicholls, Dasha</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Eating+Disorders+Review%22">European Eating Disorders Review</searchLink>. Jul2025, Vol. 33 Issue 4, p691-699. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Oxytocin%22">Oxytocin</searchLink><br /><searchLink fieldCode="DE" term="%22Intranasal+administration%22">Intranasal administration</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+sampling%22">Statistical sampling</searchLink><br /><searchLink fieldCode="DE" term="%22Blind+experiment%22">Blind experiment</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Eating+disorders%22">Eating disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Crossover+trials%22">Crossover trials</searchLink><br /><searchLink fieldCode="DE" term="%22Communication%22">Communication</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescence%22">Adolescence</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Eating disorders (ED) typically emerge in adolescence, a critical period for brain development and peer bonding. Interpersonal difficulties—particularly social anxiety—frequently co‐occur with ED. Oxytocin is a neuropeptide that modulates social cognition and linked to prosocial effects. To date, no study has investigated oxytocin's effects on negative interpretation bias toward ambiguous information in adolescents with ED. Methods: Forty‐eight female adolescents aged 16 to 17 years with and without EDs took part in a placebo‐controlled, double‐blinded, randomised, crossover trial investigating the effects of 24 IU intranasal oxytocin on negative interpretations of ambiguous scenarios. Participants and controls were tested twice, approximately one week apart. Results: Contrary to hypothesis, oxytocin increased negative interpretations overall (p = 0.019, large effect). Adolescent females with AN or BN made more negative interpretations than controls when presented with ambiguous information. There was no group effect for those who reached or did not reach threshold on an autism screen. Conclusions: This study suggests adolescents with EDs interpret ambiguous information more negatively than controls and that oxytocin administration amplifies negative responses to ambiguity in adolescent females, including in controls. Research tools that effectively identify these biases would help to widen the scope of ED treatments for adolescents. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Eating Disorders Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=185988647
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/erv.3167
    Languages:
      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 691
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      – SubjectFull: Oxytocin
        Type: general
      – SubjectFull: Intranasal administration
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Statistical sampling
        Type: general
      – SubjectFull: Blind experiment
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Randomized controlled trials
        Type: general
      – SubjectFull: Eating disorders
        Type: general
      – SubjectFull: Crossover trials
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      – SubjectFull: Communication
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      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Adolescence
        Type: general
    Titles:
      – TitleFull: Oxytocin Amplifies Negative Response to Ambiguity in Adolescent Females With and Without Eating Disorders.
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            NameFull: Burmester, Victoria
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            – D: 01
              M: 07
              Text: Jul2025
              Type: published
              Y: 2025
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