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The Association Between Pain and Physical Frailty Among Older Adults in India: Depression and Insomnia as Mediators.

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Title: The Association Between Pain and Physical Frailty Among Older Adults in India: Depression and Insomnia as Mediators.
Authors: Muhammad, T., Pai, Manacy, Ali, Waad
Source: Experimental Aging Research. Jul-Sep2025, Vol. 51 Issue 4, p393-411. 19p.
Subjects: Pain measurement, Health services accessibility, Frail elderly, Insomnia, Probability theory, Multiple regression analysis, Sex distribution, Food security, Descriptive statistics, Age distribution, Longitudinal method, Odds ratio, Chronic diseases, Financial stress, Aging, Quality of life, Confidence intervals, Psychosocial factors, Mental depression, Well-being, Symptoms, Old age
Geographic Terms: India
Abstract: Objectives: To investigate the association between body pain and physical frailty among older adults in India and to examine whether this association is mediated by symptoms of depression and insomnia. Methods: Data were obtained from the Longitudinal Aging Study in India, comprising 31,464 adults aged 60 and older. Physical frailty was assessed using a modified version of the frailty phenotype developed by Fried and colleagues. Multivariable logistic regression was used to analyze associations, and the Karlson–Holm–Breen method was employed to evaluate mediation effects. Results: The prevalence of frailty was 30.65%, with women showing a higher prevalence than men (33.16% vs. 27.85%). Older adults experiencing body pain had increased odds of frailty (adjusted odds ratio [aOR]: 1.17, 95% CI: 1.06–1.35). Depression (aOR: 1.70, 95% CI: 1.44–2.01) and insomnia symptoms (aOR: 1.58, 95% CI: 1.38–1.81) were independently associated with higher odds of frailty. Mediation analysis showed that depression mediated 8.4% of the association between pain and frailty in men and 6.11% in women. Insomnia symptoms mediated 11.47% of the association in men and 14.54% in women. Conclusion: Body pain was significantly associated with a higher likelihood of frailty among older adults in India. Symptoms of depression and insomnia partially mediated this association, with a stronger mediating effect observed for insomnia in women. Inclusive health care strategies addressing pain, depression, and insomnia could help mitigate the risk of frailty in this population. [ABSTRACT FROM AUTHOR]
Copyright of Experimental Aging Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The Association Between Pain and Physical Frailty Among Older Adults in India: Depression and Insomnia as Mediators.
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  Data: <searchLink fieldCode="AR" term="%22Muhammad%2C+T%2E%22">Muhammad, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Pai%2C+Manacy%22">Pai, Manacy</searchLink><br /><searchLink fieldCode="AR" term="%22Ali%2C+Waad%22">Ali, Waad</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Experimental+Aging+Research%22">Experimental Aging Research</searchLink>. Jul-Sep2025, Vol. 51 Issue 4, p393-411. 19p.
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  Data: <searchLink fieldCode="DE" term="%22Pain+measurement%22">Pain measurement</searchLink><br /><searchLink fieldCode="DE" term="%22Health+services+accessibility%22">Health services accessibility</searchLink><br /><searchLink fieldCode="DE" term="%22Frail+elderly%22">Frail elderly</searchLink><br /><searchLink fieldCode="DE" term="%22Insomnia%22">Insomnia</searchLink><br /><searchLink fieldCode="DE" term="%22Probability+theory%22">Probability theory</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+distribution%22">Sex distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Food+security%22">Food security</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Age+distribution%22">Age distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+diseases%22">Chronic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Financial+stress%22">Financial stress</searchLink><br /><searchLink fieldCode="DE" term="%22Aging%22">Aging</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Psychosocial+factors%22">Psychosocial factors</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Well-being%22">Well-being</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Old+age%22">Old age</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22India%22">India</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objectives: To investigate the association between body pain and physical frailty among older adults in India and to examine whether this association is mediated by symptoms of depression and insomnia. Methods: Data were obtained from the Longitudinal Aging Study in India, comprising 31,464 adults aged 60 and older. Physical frailty was assessed using a modified version of the frailty phenotype developed by Fried and colleagues. Multivariable logistic regression was used to analyze associations, and the Karlson–Holm–Breen method was employed to evaluate mediation effects. Results: The prevalence of frailty was 30.65%, with women showing a higher prevalence than men (33.16% vs. 27.85%). Older adults experiencing body pain had increased odds of frailty (adjusted odds ratio [aOR]: 1.17, 95% CI: 1.06–1.35). Depression (aOR: 1.70, 95% CI: 1.44–2.01) and insomnia symptoms (aOR: 1.58, 95% CI: 1.38–1.81) were independently associated with higher odds of frailty. Mediation analysis showed that depression mediated 8.4% of the association between pain and frailty in men and 6.11% in women. Insomnia symptoms mediated 11.47% of the association in men and 14.54% in women. Conclusion: Body pain was significantly associated with a higher likelihood of frailty among older adults in India. Symptoms of depression and insomnia partially mediated this association, with a stronger mediating effect observed for insomnia in women. Inclusive health care strategies addressing pain, depression, and insomnia could help mitigate the risk of frailty in this population. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Experimental Aging Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/0361073X.2024.2429314
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 19
        StartPage: 393
    Subjects:
      – SubjectFull: Pain measurement
        Type: general
      – SubjectFull: Health services accessibility
        Type: general
      – SubjectFull: Frail elderly
        Type: general
      – SubjectFull: Insomnia
        Type: general
      – SubjectFull: Probability theory
        Type: general
      – SubjectFull: Multiple regression analysis
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Food security
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Age distribution
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Odds ratio
        Type: general
      – SubjectFull: Chronic diseases
        Type: general
      – SubjectFull: Financial stress
        Type: general
      – SubjectFull: Aging
        Type: general
      – SubjectFull: Quality of life
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Psychosocial factors
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Well-being
        Type: general
      – SubjectFull: Symptoms
        Type: general
      – SubjectFull: Old age
        Type: general
      – SubjectFull: India
        Type: general
    Titles:
      – TitleFull: The Association Between Pain and Physical Frailty Among Older Adults in India: Depression and Insomnia as Mediators.
        Type: main
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            NameFull: Muhammad, T.
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            NameFull: Pai, Manacy
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            NameFull: Ali, Waad
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            – D: 01
              M: 07
              Text: Jul-Sep2025
              Type: published
              Y: 2025
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              Value: 0361073X
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              Value: 51
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            – TitleFull: Experimental Aging Research
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