View in EDS HTML Full Text PDF Full Text

Neurocognitive dysfunction in adolescents with recent onset major depressive disorder: a cross-sectional comparative study.

Saved in:
Bibliographic Details
Title: Neurocognitive dysfunction in adolescents with recent onset major depressive disorder: a cross-sectional comparative study.
Authors: Bienek, Olga, Allott, Kelly, Antonucci, Linda, Bertolino, Alessandro, Bonivento, Carolina, Borgwardt, Stephan, Brambilla, Paolo, Chisholm, Katharine, Dannlowski, Udo, Lichtenstein, Theresa K., Kambeitz, Joseph, Kambeitz-Ilankovic, Lana, Koutsouleris, Nikolaos, Lencer, Rebekka, Griffiths, Siân Lowri, Maggioni, Eleonora, Meisenzahl, Eva, Pantelis, Christos, Rosen, Marlene, Ruhrmann, Stephan
Source: European Child & Adolescent Psychiatry. Jun2025, Vol. 34 Issue 6, p1873-1882. 10p.
Subjects: Cognition disorders diagnosis, Cross-sectional method, Adolescent psychiatry, Disease duration, Descriptive statistics, Age factors in disease, Comparative studies, Factor analysis, Psychological tests, Mental depression, Adolescence, Adults
Abstract: The aim of this study was to examine the neurocognitive deficits associated with the first episode of major depressive disorder (recent onset depression, ROD) in adolescents as compared to adult patients. Cross-sectional neurocognitive data from the baseline assessments of the PRONIA study with N = 650 (55.31% females) were analyzed. Based on a principal component analysis of eleven neurocognitive tests, we constructed an overall neurocognitive performance (NP) score. We examined mean score differences in NP between the groups of healthy controls (HC) and ROD and between adolescents (15–21 years) and adults (22–40 years) within a GLM approach. This accounts for unbalanced data with focus on interaction effects while controlling for effects of medication and educational years. Our results show lower NP for the ROD as compared to the HC group (d = − 0.29, p =.046) and lower NP for the adolescent group as compared to the adult group (d = − 0.29; p <.039). There was no interaction between these two group effects (F = 1.11; p =.29). Our findings suggest that the detrimental effect of ROD on neurocognitive functioning is comparable in adolescent and adult patients, since lower scores in adolescent patients are explained by effects of age and education. Neurocognitive impairment is an under addressed issue in clinical treatment guidelines for adolescent MDD. We suggest efficient monitoring in clinical practice by using an aggregate of the Digit Symbol Substitution Test and the Trail Making Test B, which highly correlated with the overall score of NP (r = 0.82). [ABSTRACT FROM AUTHOR]
Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 186157328
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Neurocognitive dysfunction in adolescents with recent onset major depressive disorder: a cross-sectional comparative study.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bienek%2C+Olga%22&quot;&gt;Bienek, Olga&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Allott%2C+Kelly%22&quot;&gt;Allott, Kelly&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Antonucci%2C+Linda%22&quot;&gt;Antonucci, Linda&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bertolino%2C+Alessandro%22&quot;&gt;Bertolino, Alessandro&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bonivento%2C+Carolina%22&quot;&gt;Bonivento, Carolina&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Borgwardt%2C+Stephan%22&quot;&gt;Borgwardt, Stephan&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Brambilla%2C+Paolo%22&quot;&gt;Brambilla, Paolo&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chisholm%2C+Katharine%22&quot;&gt;Chisholm, Katharine&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dannlowski%2C+Udo%22&quot;&gt;Dannlowski, Udo&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lichtenstein%2C+Theresa+K%2E%22&quot;&gt;Lichtenstein, Theresa K.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kambeitz%2C+Joseph%22&quot;&gt;Kambeitz, Joseph&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kambeitz-Ilankovic%2C+Lana%22&quot;&gt;Kambeitz-Ilankovic, Lana&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Koutsouleris%2C+Nikolaos%22&quot;&gt;Koutsouleris, Nikolaos&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lencer%2C+Rebekka%22&quot;&gt;Lencer, Rebekka&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Griffiths%2C+Si&#226;n+Lowri%22&quot;&gt;Griffiths, Si&#226;n Lowri&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Maggioni%2C+Eleonora%22&quot;&gt;Maggioni, Eleonora&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Meisenzahl%2C+Eva%22&quot;&gt;Meisenzahl, Eva&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pantelis%2C+Christos%22&quot;&gt;Pantelis, Christos&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rosen%2C+Marlene%22&quot;&gt;Rosen, Marlene&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ruhrmann%2C+Stephan%22&quot;&gt;Ruhrmann, Stephan&lt;/searchLink&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Child+%26+Adolescent+Psychiatry%22&quot;&gt;European Child &amp; Adolescent Psychiatry&lt;/searchLink&gt;. Jun2025, Vol. 34 Issue 6, p1873-1882. 10p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cognition+disorders+diagnosis%22&quot;&gt;Cognition disorders diagnosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cross-sectional+method%22&quot;&gt;Cross-sectional method&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Adolescent+psychiatry%22&quot;&gt;Adolescent psychiatry&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Disease+duration%22&quot;&gt;Disease duration&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Descriptive+statistics%22&quot;&gt;Descriptive statistics&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Age+factors+in+disease%22&quot;&gt;Age factors in disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Comparative+studies%22&quot;&gt;Comparative studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Factor+analysis%22&quot;&gt;Factor analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychological+tests%22&quot;&gt;Psychological tests&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+depression%22&quot;&gt;Mental depression&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Adolescence%22&quot;&gt;Adolescence&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Adults%22&quot;&gt;Adults&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The aim of this study was to examine the neurocognitive deficits associated with the first episode of major depressive disorder (recent onset depression, ROD) in adolescents as compared to adult patients. Cross-sectional neurocognitive data from the baseline assessments of the PRONIA study with N = 650 (55.31% females) were analyzed. Based on a principal component analysis of eleven neurocognitive tests, we constructed an overall neurocognitive performance (NP) score. We examined mean score differences in NP between the groups of healthy controls (HC) and ROD and between adolescents (15–21 years) and adults (22–40 years) within a GLM approach. This accounts for unbalanced data with focus on interaction effects while controlling for effects of medication and educational years. Our results show lower NP for the ROD as compared to the HC group (d = − 0.29, p =.046) and lower NP for the adolescent group as compared to the adult group (d = − 0.29; p &lt;.039). There was no interaction between these two group effects (F = 1.11; p =.29). Our findings suggest that the detrimental effect of ROD on neurocognitive functioning is comparable in adolescent and adult patients, since lower scores in adolescent patients are explained by effects of age and education. Neurocognitive impairment is an under addressed issue in clinical treatment guidelines for adolescent MDD. We suggest efficient monitoring in clinical practice by using an aggregate of the Digit Symbol Substitution Test and the Trail Making Test B, which highly correlated with the overall score of NP (r = 0.82). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of European Child &amp; Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=186157328
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00787-024-02599-0
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 1873
    Subjects:
      – SubjectFull: Cognition disorders diagnosis
        Type: general
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Adolescent psychiatry
        Type: general
      – SubjectFull: Disease duration
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Age factors in disease
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Factor analysis
        Type: general
      – SubjectFull: Psychological tests
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Adolescence
        Type: general
      – SubjectFull: Adults
        Type: general
    Titles:
      – TitleFull: Neurocognitive dysfunction in adolescents with recent onset major depressive disorder: a cross-sectional comparative study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bienek, Olga
      – PersonEntity:
          Name:
            NameFull: Allott, Kelly
      – PersonEntity:
          Name:
            NameFull: Antonucci, Linda
      – PersonEntity:
          Name:
            NameFull: Bertolino, Alessandro
      – PersonEntity:
          Name:
            NameFull: Bonivento, Carolina
      – PersonEntity:
          Name:
            NameFull: Borgwardt, Stephan
      – PersonEntity:
          Name:
            NameFull: Brambilla, Paolo
      – PersonEntity:
          Name:
            NameFull: Chisholm, Katharine
      – PersonEntity:
          Name:
            NameFull: Dannlowski, Udo
      – PersonEntity:
          Name:
            NameFull: Lichtenstein, Theresa K.
      – PersonEntity:
          Name:
            NameFull: Kambeitz, Joseph
      – PersonEntity:
          Name:
            NameFull: Kambeitz-Ilankovic, Lana
      – PersonEntity:
          Name:
            NameFull: Koutsouleris, Nikolaos
      – PersonEntity:
          Name:
            NameFull: Lencer, Rebekka
      – PersonEntity:
          Name:
            NameFull: Griffiths, Siân Lowri
      – PersonEntity:
          Name:
            NameFull: Maggioni, Eleonora
      – PersonEntity:
          Name:
            NameFull: Meisenzahl, Eva
      – PersonEntity:
          Name:
            NameFull: Pantelis, Christos
      – PersonEntity:
          Name:
            NameFull: Rosen, Marlene
      – PersonEntity:
          Name:
            NameFull: Ruhrmann, Stephan
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 10188827
          Numbering:
            – Type: volume
              Value: 34
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: European Child & Adolescent Psychiatry
              Type: main
ResultId 1