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Feasibility and Preliminary Efficacy of an Executive Function Intervention for Young Children With Down Syndrome.

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Title: Feasibility and Preliminary Efficacy of an Executive Function Intervention for Young Children With Down Syndrome.
Authors: Pinks, Miranda E., Walsh, Madison M., Colaianni, Sara, Onnivello, Sara, Marcolin, Chiara, Looney, Sarah, Rossi, Elisa, Pulina, Francesca, Prince, Mark A., Riggs, Nathaniel R., Hepburn, Susan, Daunhauer, Lisa A., Kaylyn, Van Deusen, Lanfranchi, Silvia, Fidler, Deborah J.
Source: Journal of Intellectual Disability Research. Jul2025, Vol. 69 Issue 7, p546-557. 12p.
Subjects: Patient compliance, Down syndrome, Research funding, Executive function, Pilot projects, Human research subjects, Early intervention (Education), Pre-tests & post-tests, Memory, Health outcome assessment, National competency-based educational tests, Cognition, Patient participation, Children
Geographic Terms: Italy, United States
Abstract: Background: Individuals with Down syndrome (DS) have an elevated likelihood of challenges with executive function (EF) throughout the lifespan, and syndrome‐informed intervention approaches that strengthen these foundations during early childhood may be beneficial. This single group baseline versus postintervention pilot study presents findings from the implementation of a syndrome‐informed, parent‐mediated intervention designed to support the development of EF in preschool‐aged children with DS (EXPO: Executive Function Play Opportunities). Method: Participants were 34 children aged 3–7 years old with DS and their caregivers. The full sample participated in a novel 12‐week parent‐mediated intervention focused on building working memory, inhibitory control, cognitive flexibility and planning skills. Participants were evaluated at baseline and poststudy for feasibility outcomes and preliminary evidence of intervention efficacy. Results: Activities were feasible for families to implement and appropriate for the developmental range of participants in the study. Preliminary evidence of efficacy was observed via laboratory‐based EF outcome measures. Within‐sample heterogeneity in response to intervention was also observed. Conclusions: EXPO is feasible for a larger trial in its current form. Additional intervention modifications may further increase the potential impact of EXPO by addressing heterogeneity in presentations among young children with DS. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Feasibility and Preliminary Efficacy of an Executive Function Intervention for Young Children With Down Syndrome.
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  Data: <searchLink fieldCode="AR" term="%22Pinks%2C+Miranda E%2E%22">Pinks, Miranda E.</searchLink><br /><searchLink fieldCode="AR" term="%22Walsh%2C+Madison M%2E%22">Walsh, Madison M.</searchLink><br /><searchLink fieldCode="AR" term="%22Colaianni%2C+Sara%22">Colaianni, Sara</searchLink><br /><searchLink fieldCode="AR" term="%22Onnivello%2C+Sara%22">Onnivello, Sara</searchLink><br /><searchLink fieldCode="AR" term="%22Marcolin%2C+Chiara%22">Marcolin, Chiara</searchLink><br /><searchLink fieldCode="AR" term="%22Looney%2C+Sarah%22">Looney, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Rossi%2C+Elisa%22">Rossi, Elisa</searchLink><br /><searchLink fieldCode="AR" term="%22Pulina%2C+Francesca%22">Pulina, Francesca</searchLink><br /><searchLink fieldCode="AR" term="%22Prince%2C+Mark A%2E%22">Prince, Mark A.</searchLink><br /><searchLink fieldCode="AR" term="%22Riggs%2C+Nathaniel R%2E%22">Riggs, Nathaniel R.</searchLink><br /><searchLink fieldCode="AR" term="%22Hepburn%2C+Susan%22">Hepburn, Susan</searchLink><br /><searchLink fieldCode="AR" term="%22Daunhauer%2C+Lisa A%2E%22">Daunhauer, Lisa A.</searchLink><br /><searchLink fieldCode="AR" term="%22Kaylyn%2C+Van Deusen%22">Kaylyn, Van Deusen</searchLink><br /><searchLink fieldCode="AR" term="%22Lanfranchi%2C+Silvia%22">Lanfranchi, Silvia</searchLink><br /><searchLink fieldCode="AR" term="%22Fidler%2C+Deborah J%2E%22">Fidler, Deborah J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Intellectual+Disability+Research%22">Journal of Intellectual Disability Research</searchLink>. Jul2025, Vol. 69 Issue 7, p546-557. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Patient+compliance%22">Patient compliance</searchLink><br /><searchLink fieldCode="DE" term="%22Down+syndrome%22">Down syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Executive+function%22">Executive function</searchLink><br /><searchLink fieldCode="DE" term="%22Pilot+projects%22">Pilot projects</searchLink><br /><searchLink fieldCode="DE" term="%22Human+research+subjects%22">Human research subjects</searchLink><br /><searchLink fieldCode="DE" term="%22Early+intervention+%28Education%29%22">Early intervention (Education)</searchLink><br /><searchLink fieldCode="DE" term="%22Pre-tests+%26+post-tests%22">Pre-tests & post-tests</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22National+competency-based+educational+tests%22">National competency-based educational tests</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+participation%22">Patient participation</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Italy%22">Italy</searchLink><br /><searchLink fieldCode="DE" term="%22United+States%22">United States</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Individuals with Down syndrome (DS) have an elevated likelihood of challenges with executive function (EF) throughout the lifespan, and syndrome‐informed intervention approaches that strengthen these foundations during early childhood may be beneficial. This single group baseline versus postintervention pilot study presents findings from the implementation of a syndrome‐informed, parent‐mediated intervention designed to support the development of EF in preschool‐aged children with DS (EXPO: Executive Function Play Opportunities). Method: Participants were 34 children aged 3–7 years old with DS and their caregivers. The full sample participated in a novel 12‐week parent‐mediated intervention focused on building working memory, inhibitory control, cognitive flexibility and planning skills. Participants were evaluated at baseline and poststudy for feasibility outcomes and preliminary evidence of intervention efficacy. Results: Activities were feasible for families to implement and appropriate for the developmental range of participants in the study. Preliminary evidence of efficacy was observed via laboratory‐based EF outcome measures. Within‐sample heterogeneity in response to intervention was also observed. Conclusions: EXPO is feasible for a larger trial in its current form. Additional intervention modifications may further increase the potential impact of EXPO by addressing heterogeneity in presentations among young children with DS. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=186163500
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        Value: 10.1111/jir.13234
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 546
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      – SubjectFull: Patient compliance
        Type: general
      – SubjectFull: Down syndrome
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      – SubjectFull: Research funding
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      – SubjectFull: Executive function
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      – SubjectFull: Pilot projects
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      – SubjectFull: Human research subjects
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      – SubjectFull: Pre-tests & post-tests
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      – SubjectFull: Memory
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      – SubjectFull: Health outcome assessment
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      – SubjectFull: National competency-based educational tests
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      – SubjectFull: Children
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      – SubjectFull: Italy
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      – SubjectFull: United States
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      – TitleFull: Feasibility and Preliminary Efficacy of an Executive Function Intervention for Young Children With Down Syndrome.
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              Text: Jul2025
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