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Neuropsychiatric Symptoms and White Matter Hyperintensities in Older Cognitively Unimpaired Men Versus Women.

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Title: Neuropsychiatric Symptoms and White Matter Hyperintensities in Older Cognitively Unimpaired Men Versus Women.
Authors: Liampas, Ioannis, Tsirelis, Daniil, Demiri, Silvia, Siokas, Vasileios, Tsika, Antonia, Zoupa, Elli, Stamati, Polyxeni, Messinis, Lambros, Nasios, Grigorios, Dardiotis, Efthimios
Source: International Journal of Geriatric Psychiatry. Jun2025, Vol. 40 Issue 6, p1-10. 10p.
Subjects: Cognition disorders treatment, Men, Cross-sectional method, Statistical correlation, Alzheimer's disease, Women, Questionnaires, Logistic regression analysis, Research evaluation, Descriptive statistics, Eating disorders, Odds ratio, White matter (Nerve tissue), Cognition, Apathy, Symptoms, Old age
Abstract: Objectives: We aimed to examine association patterns of white matter hyperintensities (WMH) with neuropsychiatric symptoms (NPS) in men versus women. Methods: We performed a cross‐sectional analysis of data acquired from the National Alzheimer's Coordinating Center database. Cognitively unimpaired participants aged ≥ 50 years with data on WMH severity were studied. Using Cardiovascular Health Study scores, WMH were coded as no to mild (score: 0–4), moderate (score: 5–6) or extensive (score: 7–8). NPS were quantified on the Neuropsychiatric Inventory Questionnaire. For the purposes of the main analysis, participants were dichotomized for presence of each NPS (0: absent; 1: present). Adjusted binary logistic regression models estimated the odds of having each of 12 NPS by sex‐WMH status. To confirm the validity of our findings, the correlations between NPS severity and WMH burden were also separately explored in men and women. Results: Among 4617 participants with normal cognition, there were 1502 men and 2685 women with no to mild WMH changes, 102 men and 274 women with moderate WMH changes and 19 men and 35 women with extensive WMH changes. Greater WMH burden (especially extensive changes) was related to increased odds of lability symptoms (agitation, disinhibition, irritability) and apathy in men but not women. Elation and appetite disorders followed the same trend but failed to achieve statistical significance. The exploratory analysis revealed positive correlations between these symptoms' severity with WMH burden in men but not in women. Conclusions: WMH burden was differentially associated with NPS in older men versus women with normal cognition. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Neuropsychiatric Symptoms and White Matter Hyperintensities in Older Cognitively Unimpaired Men Versus Women.
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  Data: <searchLink fieldCode="AR" term="%22Liampas%2C+Ioannis%22">Liampas, Ioannis</searchLink><br /><searchLink fieldCode="AR" term="%22Tsirelis%2C+Daniil%22">Tsirelis, Daniil</searchLink><br /><searchLink fieldCode="AR" term="%22Demiri%2C+Silvia%22">Demiri, Silvia</searchLink><br /><searchLink fieldCode="AR" term="%22Siokas%2C+Vasileios%22">Siokas, Vasileios</searchLink><br /><searchLink fieldCode="AR" term="%22Tsika%2C+Antonia%22">Tsika, Antonia</searchLink><br /><searchLink fieldCode="AR" term="%22Zoupa%2C+Elli%22">Zoupa, Elli</searchLink><br /><searchLink fieldCode="AR" term="%22Stamati%2C+Polyxeni%22">Stamati, Polyxeni</searchLink><br /><searchLink fieldCode="AR" term="%22Messinis%2C+Lambros%22">Messinis, Lambros</searchLink><br /><searchLink fieldCode="AR" term="%22Nasios%2C+Grigorios%22">Nasios, Grigorios</searchLink><br /><searchLink fieldCode="AR" term="%22Dardiotis%2C+Efthimios%22">Dardiotis, Efthimios</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Geriatric+Psychiatry%22">International Journal of Geriatric Psychiatry</searchLink>. Jun2025, Vol. 40 Issue 6, p1-10. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Cognition+disorders+treatment%22">Cognition disorders treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Men%22">Men</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+correlation%22">Statistical correlation</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Women%22">Women</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Research+evaluation%22">Research evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Eating+disorders%22">Eating disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22White+matter+%28Nerve+tissue%29%22">White matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Apathy%22">Apathy</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Old+age%22">Old age</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: We aimed to examine association patterns of white matter hyperintensities (WMH) with neuropsychiatric symptoms (NPS) in men versus women. Methods: We performed a cross‐sectional analysis of data acquired from the National Alzheimer's Coordinating Center database. Cognitively unimpaired participants aged ≥ 50 years with data on WMH severity were studied. Using Cardiovascular Health Study scores, WMH were coded as no to mild (score: 0–4), moderate (score: 5–6) or extensive (score: 7–8). NPS were quantified on the Neuropsychiatric Inventory Questionnaire. For the purposes of the main analysis, participants were dichotomized for presence of each NPS (0: absent; 1: present). Adjusted binary logistic regression models estimated the odds of having each of 12 NPS by sex‐WMH status. To confirm the validity of our findings, the correlations between NPS severity and WMH burden were also separately explored in men and women. Results: Among 4617 participants with normal cognition, there were 1502 men and 2685 women with no to mild WMH changes, 102 men and 274 women with moderate WMH changes and 19 men and 35 women with extensive WMH changes. Greater WMH burden (especially extensive changes) was related to increased odds of lability symptoms (agitation, disinhibition, irritability) and apathy in men but not women. Elation and appetite disorders followed the same trend but failed to achieve statistical significance. The exploratory analysis revealed positive correlations between these symptoms' severity with WMH burden in men but not in women. Conclusions: WMH burden was differentially associated with NPS in older men versus women with normal cognition. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1002/gps.70107
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 1
    Subjects:
      – SubjectFull: Cognition disorders treatment
        Type: general
      – SubjectFull: Men
        Type: general
      – SubjectFull: Cross-sectional method
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      – SubjectFull: Statistical correlation
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      – SubjectFull: Alzheimer's disease
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      – SubjectFull: Women
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      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Logistic regression analysis
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      – SubjectFull: Research evaluation
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Eating disorders
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      – SubjectFull: Odds ratio
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      – SubjectFull: White matter (Nerve tissue)
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      – SubjectFull: Apathy
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      – SubjectFull: Symptoms
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      – SubjectFull: Old age
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    Titles:
      – TitleFull: Neuropsychiatric Symptoms and White Matter Hyperintensities in Older Cognitively Unimpaired Men Versus Women.
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            – D: 01
              M: 06
              Text: Jun2025
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              Y: 2025
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