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Impact of Obstetric Complications in Subjects at Clinical High Risk for Psychosis: A Systematic Review and Meta‐Analysis.

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Title: Impact of Obstetric Complications in Subjects at Clinical High Risk for Psychosis: A Systematic Review and Meta‐Analysis.
Authors: Baeza, Inmaculada (AUTHOR), Tor, Jordina (AUTHOR), de la Serna, Elena (AUTHOR), Sugranyes, Gisela (AUTHOR), Crispi, Fàtima (AUTHOR), Izquierdo‐Renau, Montserrat (AUTHOR), del Olmo, Marta (AUTHOR), Dolz, Montserrat (AUTHOR), García‐Rizo, Clemente (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Aug2025, Vol. 152 Issue 2, p81-93. 13p.
Subjects: Labor complications (Obstetrics), Psychoses, Schizophrenia, Disease prevalence
Abstract: Introduction: Exposure to obstetric complications (OCs) increases the risk of developing psychosis and schizophrenia in offspring. However, studies with subjects at clinical high risk for psychosis (CHR) have reported inconsistent results. We conducted a systematic review and meta‐analysis to evaluate the prevalence of OCs among CHR subjects and controls and examine their impact on the transition to psychosis. Methods: Four databases (Web of Science, PubMed, Latindex, and Dialnet) were systematically searched for articles published between 1995 and June 6, 2024. The risk of bias was assessed using the Newcastle–Ottawa scale. Articles providing data on OCs in CHR subjects were included. Results: A total of 6037 records were retrieved through systematic and citation searches. Nine articles met the inclusion criteria for our systematic review and provided data for meta‐analysis. A total of 555 CHR participants were included. Meta‐analysis showed a significantly higher prevalence of OCs in CHR subjects versus controls: RR = 1.45 (95% CI: 1.16, 1.81), (Z = 3.27, p = 0.0011). Data from three longitudinal studies assessed transition to psychosis and our meta‐analysis found a trend toward an increased risk of transition in CHR subjects with a history of OCs compared to others: RR = 2.05 (95% CI: 0.98, 4.26), Z = 1.91, p = 0.056. Conclusions: CHR for psychosis was associated with OCs, though their role in the transition to psychosis requires further study. OCs should be recorded and analyzed in CHR individuals, considering their potential clinical implications. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Impact of Obstetric Complications in Subjects at Clinical High Risk for Psychosis: A Systematic Review and Meta‐Analysis.
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  Data: <searchLink fieldCode="AR" term="%22Baeza%2C+Inmaculada%22">Baeza, Inmaculada</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tor%2C+Jordina%22">Tor, Jordina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+la+Serna%2C+Elena%22">de la Serna, Elena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sugranyes%2C+Gisela%22">Sugranyes, Gisela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Crispi%2C+Fàtima%22">Crispi, Fàtima</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Izquierdo‐Renau%2C+Montserrat%22">Izquierdo‐Renau, Montserrat</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22del+Olmo%2C+Marta%22">del Olmo, Marta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dolz%2C+Montserrat%22">Dolz, Montserrat</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22García‐Rizo%2C+Clemente%22">García‐Rizo, Clemente</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Aug2025, Vol. 152 Issue 2, p81-93. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Labor+complications+%28Obstetrics%29%22">Labor complications (Obstetrics)</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+prevalence%22">Disease prevalence</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Introduction: Exposure to obstetric complications (OCs) increases the risk of developing psychosis and schizophrenia in offspring. However, studies with subjects at clinical high risk for psychosis (CHR) have reported inconsistent results. We conducted a systematic review and meta‐analysis to evaluate the prevalence of OCs among CHR subjects and controls and examine their impact on the transition to psychosis. Methods: Four databases (Web of Science, PubMed, Latindex, and Dialnet) were systematically searched for articles published between 1995 and June 6, 2024. The risk of bias was assessed using the Newcastle–Ottawa scale. Articles providing data on OCs in CHR subjects were included. Results: A total of 6037 records were retrieved through systematic and citation searches. Nine articles met the inclusion criteria for our systematic review and provided data for meta‐analysis. A total of 555 CHR participants were included. Meta‐analysis showed a significantly higher prevalence of OCs in CHR subjects versus controls: RR = 1.45 (95% CI: 1.16, 1.81), (Z = 3.27, p = 0.0011). Data from three longitudinal studies assessed transition to psychosis and our meta‐analysis found a trend toward an increased risk of transition in CHR subjects with a history of OCs compared to others: RR = 2.05 (95% CI: 0.98, 4.26), Z = 1.91, p = 0.056. Conclusions: CHR for psychosis was associated with OCs, though their role in the transition to psychosis requires further study. OCs should be recorded and analyzed in CHR individuals, considering their potential clinical implications. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Aug2025
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