Effects of psilocybin, the 5-HT2A receptor agonist TCB-2, and the 5-HT2A receptor antagonist M100907 on visual attention in male mice in the continuous performance test.
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| Title: | Effects of psilocybin, the 5-HT |
|---|---|
| Authors: | Rahbarnia, Arya (AUTHOR), Li, Zhaoxia (AUTHOR), Fletcher, Paul J. (AUTHOR) |
| Source: | Psychopharmacology. Jul2025, Vol. 242 Issue 7, p1563-1575. 13p. |
| Subjects: | Psilocybin, Continuous performance test, Neurobehavioral disorders, Laboratory mice, Serotonin antagonists, Selectivity (Psychology), Serotonin receptors |
| Abstract: | Rationale: Neuropsychiatric disorders such as depression are characterized in part by attention deficits. Attention is modulated by the serotonin (5-HT) neurotransmitter system. The 5-HT2A agonist and hallucinogen psilocybin (PSI) is a promising treatment for disorders characterized by attention changes. However, few studies have investigated PSI's direct effect on attention. Objective: Using the rodent continuous performance task (CPT), we assessed PSI's effect on attention. We also evaluated the impact of 5-HT2A receptor agonist TCB-2 and antagonist M100907 for comparative purposes. Methods: In the CPT, mice learned to distinguish visual targets from non-targets for milkshake reward. Performance was then tested following injections of PSI (0.3, 1, and 3 mg/kg), TCB-2 (0.3, 1, and 3 mg/kg), or M100907 (0.1, 0.3, and 1 mg/kg). Subsequently, drug effects were then evaluated using a more difficult CPT with variable stimulus durations. Mice were then tested on the CPT following repeated PSI injections. Drug effects on locomotor activity were also measured. Results: In the CPT, all three drugs reduced hit and false alarm rate and induced conservative responding. PSI also reduced target discrimination. These effects were seen primarily at doses that also significantly reduced locomotor activity. No drug effects were seen on the more difficult CPT or following repeated PSI injections. Conclusions: Psilocybin, TCB-2, and M100907 impaired performance of the CPT. However, this may be in part due to drug-induced locomotor changes. The results provide little support for the idea that psilocybin alters visual attention, or that 5-HT2A receptors modulate this process. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 186374451 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of psilocybin, the 5-HT<subscript>2A</subscript> receptor agonist TCB-2, and the 5-HT<subscript>2A</subscript> receptor antagonist M100907 on visual attention in male mice in the continuous performance test. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rahbarnia%2C+Arya%22">Rahbarnia, Arya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Zhaoxia%22">Li, Zhaoxia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fletcher%2C+Paul+J%2E%22">Fletcher, Paul J.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jul2025, Vol. 242 Issue 7, p1563-1575. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Psilocybin%22">Psilocybin</searchLink><br /><searchLink fieldCode="DE" term="%22Continuous+performance+test%22">Continuous performance test</searchLink><br /><searchLink fieldCode="DE" term="%22Neurobehavioral+disorders%22">Neurobehavioral disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin+antagonists%22">Serotonin antagonists</searchLink><br /><searchLink fieldCode="DE" term="%22Selectivity+%28Psychology%29%22">Selectivity (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin+receptors%22">Serotonin receptors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Neuropsychiatric disorders such as depression are characterized in part by attention deficits. Attention is modulated by the serotonin (5-HT) neurotransmitter system. The 5-HT2A agonist and hallucinogen psilocybin (PSI) is a promising treatment for disorders characterized by attention changes. However, few studies have investigated PSI's direct effect on attention. Objective: Using the rodent continuous performance task (CPT), we assessed PSI's effect on attention. We also evaluated the impact of 5-HT2A receptor agonist TCB-2 and antagonist M100907 for comparative purposes. Methods: In the CPT, mice learned to distinguish visual targets from non-targets for milkshake reward. Performance was then tested following injections of PSI (0.3, 1, and 3 mg/kg), TCB-2 (0.3, 1, and 3 mg/kg), or M100907 (0.1, 0.3, and 1 mg/kg). Subsequently, drug effects were then evaluated using a more difficult CPT with variable stimulus durations. Mice were then tested on the CPT following repeated PSI injections. Drug effects on locomotor activity were also measured. Results: In the CPT, all three drugs reduced hit and false alarm rate and induced conservative responding. PSI also reduced target discrimination. These effects were seen primarily at doses that also significantly reduced locomotor activity. No drug effects were seen on the more difficult CPT or following repeated PSI injections. Conclusions: Psilocybin, TCB-2, and M100907 impaired performance of the CPT. However, this may be in part due to drug-induced locomotor changes. The results provide little support for the idea that psilocybin alters visual attention, or that 5-HT2A receptors modulate this process. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-023-06474-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1563 Subjects: – SubjectFull: Psilocybin Type: general – SubjectFull: Continuous performance test Type: general – SubjectFull: Neurobehavioral disorders Type: general – SubjectFull: Laboratory mice Type: general – SubjectFull: Serotonin antagonists Type: general – SubjectFull: Selectivity (Psychology) Type: general – SubjectFull: Serotonin receptors Type: general Titles: – TitleFull: Effects of psilocybin, the 5-HT2A receptor agonist TCB-2, and the 5-HT2A receptor antagonist M100907 on visual attention in male mice in the continuous performance test. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rahbarnia, Arya – PersonEntity: Name: NameFull: Li, Zhaoxia – PersonEntity: Name: NameFull: Fletcher, Paul J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 242 – Type: issue Value: 7 Titles: – TitleFull: Psychopharmacology Type: main |
| ResultId | 1 |
