Unraveling psilocybin's therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression.
Saved in:
| Title: | Unraveling psilocybin's therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression. |
|---|---|
| Authors: | Kolasa, Magdalena (AUTHOR), Nikiforuk, Agnieszka (AUTHOR), Korlatowicz, Agata (AUTHOR), Solich, Joanna (AUTHOR), Potasiewicz, Agnieszka (AUTHOR), Dziedzicka-Wasylewska, Marta (AUTHOR), Bugno, Ryszard (AUTHOR), Hogendorf, Adam (AUTHOR), Bojarski, Andrzej (AUTHOR), Faron-Górecka, Agata (AUTHOR) |
| Source: | Psychopharmacology. Jul2025, Vol. 242 Issue 7, p1607-1625. 19p. |
| Subjects: | Psilocybin, Neuroplasticity, Mental depression, Laboratory rats, Behavioral assessment, Brain-derived neurotrophic factor |
| Abstract: | Rationale: Our study aimed to unravel the unknown mechanisms behind the exceptional efficacy of Psilocybin (PSI) in treating treatment-resistant depression (TRD). Focusing on Wistar-Kyoto (WKY) rats with a TRD phenotype and Wistar (WIS) rats as a normative comparison, we investigated behavioral and neuroplasticity-related responses to PSI, striving to shed light on the distinctive features of its antidepressant effects. Objectives: We set out to assess the behavioral impact of acute and prolonged PSI administration on WKY and WIS rats, employing Novel Object Recognition (NORT), Social Interaction (SI), and Forced Swimming Test (FST). Our secondary objectives involved exploring strain-specific alterations in neuroplasticity-related parameters, including brain-derived neurotrophic factor (BDNF) and activity-regulated cytoskeleton-associated protein (Arc). Methods: Conducting post-acute and extended assessments after a single PSI administration, we applied behavioral tests and biochemical analyses to measure serum BDNF levels and neuroplasticity-related parameters in the prefrontal cortex. Statistical analyses were deployed to discern significant differences between the rat strains and assess the impact of PSI on behavioral and biochemical outcomes. Results: Our findings uncovered significant behavioral disparities between WKY and WIS rats, indicating passive behavior and social withdrawal in the former. PSI demonstrated pronounced pro-social and antidepressant effects in both strains, each with its distinctive temporal trajectory. Notably, we identified strain-specific variations in BDNF-related signaling and observed the modulation of Arc expression in WKY rats. Conclusions: Our study delineated mood-related behavioral nuances between WKY and WIS rat strains, underscoring the antidepressant and pro-social properties of PSI in both groups. The distinct temporal patterns of observed changes and the identified strain-specific neuroplasticity alterations provide valuable insights into the TRD phenotype and the mechanisms underpinning the efficacy of PSI. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 186374456 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Unraveling psilocybin's therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kolasa%2C+Magdalena%22">Kolasa, Magdalena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nikiforuk%2C+Agnieszka%22">Nikiforuk, Agnieszka</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Korlatowicz%2C+Agata%22">Korlatowicz, Agata</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Solich%2C+Joanna%22">Solich, Joanna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Potasiewicz%2C+Agnieszka%22">Potasiewicz, Agnieszka</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dziedzicka-Wasylewska%2C+Marta%22">Dziedzicka-Wasylewska, Marta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bugno%2C+Ryszard%22">Bugno, Ryszard</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hogendorf%2C+Adam%22">Hogendorf, Adam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bojarski%2C+Andrzej%22">Bojarski, Andrzej</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Faron-Górecka%2C+Agata%22">Faron-Górecka, Agata</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jul2025, Vol. 242 Issue 7, p1607-1625. 19p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Psilocybin%22">Psilocybin</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Behavioral+assessment%22">Behavioral assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Brain-derived+neurotrophic+factor%22">Brain-derived neurotrophic factor</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Our study aimed to unravel the unknown mechanisms behind the exceptional efficacy of Psilocybin (PSI) in treating treatment-resistant depression (TRD). Focusing on Wistar-Kyoto (WKY) rats with a TRD phenotype and Wistar (WIS) rats as a normative comparison, we investigated behavioral and neuroplasticity-related responses to PSI, striving to shed light on the distinctive features of its antidepressant effects. Objectives: We set out to assess the behavioral impact of acute and prolonged PSI administration on WKY and WIS rats, employing Novel Object Recognition (NORT), Social Interaction (SI), and Forced Swimming Test (FST). Our secondary objectives involved exploring strain-specific alterations in neuroplasticity-related parameters, including brain-derived neurotrophic factor (BDNF) and activity-regulated cytoskeleton-associated protein (Arc). Methods: Conducting post-acute and extended assessments after a single PSI administration, we applied behavioral tests and biochemical analyses to measure serum BDNF levels and neuroplasticity-related parameters in the prefrontal cortex. Statistical analyses were deployed to discern significant differences between the rat strains and assess the impact of PSI on behavioral and biochemical outcomes. Results: Our findings uncovered significant behavioral disparities between WKY and WIS rats, indicating passive behavior and social withdrawal in the former. PSI demonstrated pronounced pro-social and antidepressant effects in both strains, each with its distinctive temporal trajectory. Notably, we identified strain-specific variations in BDNF-related signaling and observed the modulation of Arc expression in WKY rats. Conclusions: Our study delineated mood-related behavioral nuances between WKY and WIS rat strains, underscoring the antidepressant and pro-social properties of PSI in both groups. The distinct temporal patterns of observed changes and the identified strain-specific neuroplasticity alterations provide valuable insights into the TRD phenotype and the mechanisms underpinning the efficacy of PSI. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=186374456 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-024-06644-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 19 StartPage: 1607 Subjects: – SubjectFull: Psilocybin Type: general – SubjectFull: Neuroplasticity Type: general – SubjectFull: Mental depression Type: general – SubjectFull: Laboratory rats Type: general – SubjectFull: Behavioral assessment Type: general – SubjectFull: Brain-derived neurotrophic factor Type: general Titles: – TitleFull: Unraveling psilocybin's therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kolasa, Magdalena – PersonEntity: Name: NameFull: Nikiforuk, Agnieszka – PersonEntity: Name: NameFull: Korlatowicz, Agata – PersonEntity: Name: NameFull: Solich, Joanna – PersonEntity: Name: NameFull: Potasiewicz, Agnieszka – PersonEntity: Name: NameFull: Dziedzicka-Wasylewska, Marta – PersonEntity: Name: NameFull: Bugno, Ryszard – PersonEntity: Name: NameFull: Hogendorf, Adam – PersonEntity: Name: NameFull: Bojarski, Andrzej – PersonEntity: Name: NameFull: Faron-Górecka, Agata IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 242 – Type: issue Value: 7 Titles: – TitleFull: Psychopharmacology Type: main |
| ResultId | 1 |
