View in EDS HTML Full Text PDF Full Text

Neural mass modeling reveals that hyperexcitability underpins slow‐wave sleep changes in children with epilepsy.

Saved in:
Bibliographic Details
Title: Neural mass modeling reveals that hyperexcitability underpins slow‐wave sleep changes in children with epilepsy.
Authors: Dunstan, Dominic M. (AUTHOR), Chan, Samantha Y. S. (AUTHOR), Goodfellow, Marc (AUTHOR)
Source: Epilepsia (Series 4). May2025, Vol. 66 Issue 5, p1652-1664. 13p.
Subjects: Slow wave sleep, Epilepsy, Minors, Hyperkinesia, Electroencephalography, Computational neuroscience, Neural transmission disorders
Abstract: Objective: The relationship between sleep and epilepsy is important but imperfectly understood. We sought to understand the mechanisms that explain the differences in sleep homeostasis observed in children with epilepsy. Methods: We used a neural mass model to replicate sleep electroencephalography (EEG) recorded from 15 children with focal lesional epilepsies and 16 healthy age‐matched controls. Different parameter sets were recovered in the model for each subject. Results: The model revealed that sleep EEG differences are driven by enhanced firing rates in the neuronal populations of patients, which arise predominantly due to enhanced excitatory synaptic currents. These differences were more marked in patients who had seizures within 72 h after the sleep recording. Furthermore, model parameters inferred from patients resided closer to model parameters inferred from a typical seizure rhythm. Significance: These results demonstrate that brain mechanisms relating to epilepsy manifest in the interictal EEG in slow‐wave sleep, and that EEG recorded from patients can be mapped to synaptic deficits that may explain their predisposition to seizures. Neural mass models inferred from sleep EEG data have the potential to generate new biomarkers to predict seizure occurrence and inform treatment decisions. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 186462334
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Neural mass modeling reveals that hyperexcitability underpins slow‐wave sleep changes in children with epilepsy.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Dunstan%2C+Dominic+M%2E%22">Dunstan, Dominic M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chan%2C+Samantha+Y%2E+S%2E%22">Chan, Samantha Y. S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goodfellow%2C+Marc%22">Goodfellow, Marc</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. May2025, Vol. 66 Issue 5, p1652-1664. 13p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Slow+wave+sleep%22">Slow wave sleep</searchLink><br /><searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Minors%22">Minors</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperkinesia%22">Hyperkinesia</searchLink><br /><searchLink fieldCode="DE" term="%22Electroencephalography%22">Electroencephalography</searchLink><br /><searchLink fieldCode="DE" term="%22Computational+neuroscience%22">Computational neuroscience</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+transmission+disorders%22">Neural transmission disorders</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: The relationship between sleep and epilepsy is important but imperfectly understood. We sought to understand the mechanisms that explain the differences in sleep homeostasis observed in children with epilepsy. Methods: We used a neural mass model to replicate sleep electroencephalography (EEG) recorded from 15 children with focal lesional epilepsies and 16 healthy age‐matched controls. Different parameter sets were recovered in the model for each subject. Results: The model revealed that sleep EEG differences are driven by enhanced firing rates in the neuronal populations of patients, which arise predominantly due to enhanced excitatory synaptic currents. These differences were more marked in patients who had seizures within 72 h after the sleep recording. Furthermore, model parameters inferred from patients resided closer to model parameters inferred from a typical seizure rhythm. Significance: These results demonstrate that brain mechanisms relating to epilepsy manifest in the interictal EEG in slow‐wave sleep, and that EEG recorded from patients can be mapped to synaptic deficits that may explain their predisposition to seizures. Neural mass models inferred from sleep EEG data have the potential to generate new biomarkers to predict seizure occurrence and inform treatment decisions. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=186462334
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/epi.18293
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 1652
    Subjects:
      – SubjectFull: Slow wave sleep
        Type: general
      – SubjectFull: Epilepsy
        Type: general
      – SubjectFull: Minors
        Type: general
      – SubjectFull: Hyperkinesia
        Type: general
      – SubjectFull: Electroencephalography
        Type: general
      – SubjectFull: Computational neuroscience
        Type: general
      – SubjectFull: Neural transmission disorders
        Type: general
    Titles:
      – TitleFull: Neural mass modeling reveals that hyperexcitability underpins slow‐wave sleep changes in children with epilepsy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Dunstan, Dominic M.
      – PersonEntity:
          Name:
            NameFull: Chan, Samantha Y. S.
      – PersonEntity:
          Name:
            NameFull: Goodfellow, Marc
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 00139580
          Numbering:
            – Type: volume
              Value: 66
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Epilepsia (Series 4)
              Type: main
ResultId 1