View in EDS HTML Full Text PDF Full Text

Shorter Telomeres and Faster Telomere Attrition in Individuals With Five Syndromic Forms of Intellectual Disability: A Systematic Review and Meta‐Analysis.

Saved in:
Bibliographic Details
Title: Shorter Telomeres and Faster Telomere Attrition in Individuals With Five Syndromic Forms of Intellectual Disability: A Systematic Review and Meta‐Analysis.
Authors: Hanley, Sarah M., Schutte, Nicola S., Bellamy, Jessica, Denham, Joshua
Source: Journal of Intellectual Disability Research. Aug2025, Vol. 69 Issue 8, p641-654. 14p.
Subjects: DNA analysis, Mortality risk factors, Leukocytes, Risk assessment, Cri-du-chat syndrome, Meta-analysis, Descriptive statistics, Intellectual disabilities, Systematic reviews, MEDLINE, Chronic diseases, Diseases, Online information services, Confidence intervals, Longevity, Active aging
Abstract: Background: People with intellectual disability suffer complex challenges due to adaptive functioning limitations, high rates of chronic diseases and shortened lifespans compared with the general population. Telomere shortening is a hallmark of ageing, and short telomeres are linked to neurological disorders. The main objective of this systematic review and meta‐analysis was to identify any differences in telomere length and the rate of telomere attrition in leukocytes and fibroblasts from people with intellectual disability and controls. Methods: PubMed, Scopus and ScienceDirect were searched. Articles that compared telomere length in individuals with intellectual disability to apparently healthy age‐matched controls were included. Risk of bias was assessed using the AXIS tool and data were analysed using CMA. Results: Fifteen studies comprised of 17 comparisons provided data and were included in meta‐analyses. Compared with healthy controls (N = 481), people with intellectual disability (N = 366) from a known genetic syndrome (Cri du chat, Down, Hoyeraal–Hreidarsson, Williams or Nicolaides–Baraitser) possessed shorter leukocyte telomeres (SMD: −0.853 [95% CI: −1.622 to −0.084], p = 0.03). Similarly, relative to controls (N = 16), people with syndromic intellectual disability (N = 21) possessed shorter fibroblast telomeres (−1.389 [−2.179 to −0.599], p = 0.001). Furthermore, people with syndromic forms of intellectual disability also demonstrated a faster rate (2.09‐fold) of telomere shortening. Conclusions: Consistent with epidemiological findings on mortality and morbidity risk, people with syndromic intellectual disability appear to undergo a faster rate of biological ageing compared to the general population. These findings emphasise the need for healthy ageing lifestyle (i.e., exercise and stress management) and therapeutic interventions for people with syndromic intellectual disability. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 186527212
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Shorter Telomeres and Faster Telomere Attrition in Individuals With Five Syndromic Forms of Intellectual Disability: A Systematic Review and Meta‐Analysis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Hanley%2C+Sarah M%2E%22">Hanley, Sarah M.</searchLink><br /><searchLink fieldCode="AR" term="%22Schutte%2C+Nicola S%2E%22">Schutte, Nicola S.</searchLink><br /><searchLink fieldCode="AR" term="%22Bellamy%2C+Jessica%22">Bellamy, Jessica</searchLink><br /><searchLink fieldCode="AR" term="%22Denham%2C+Joshua%22">Denham, Joshua</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Intellectual+Disability+Research%22">Journal of Intellectual Disability Research</searchLink>. Aug2025, Vol. 69 Issue 8, p641-654. 14p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22DNA+analysis%22">DNA analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Mortality+risk+factors%22">Mortality risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Leukocytes%22">Leukocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Cri-du-chat+syndrome%22">Cri-du-chat syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Meta-analysis%22">Meta-analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Intellectual+disabilities%22">Intellectual disabilities</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink><br /><searchLink fieldCode="DE" term="%22MEDLINE%22">MEDLINE</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+diseases%22">Chronic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases%22">Diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Online+information+services%22">Online information services</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Longevity%22">Longevity</searchLink><br /><searchLink fieldCode="DE" term="%22Active+aging%22">Active aging</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: People with intellectual disability suffer complex challenges due to adaptive functioning limitations, high rates of chronic diseases and shortened lifespans compared with the general population. Telomere shortening is a hallmark of ageing, and short telomeres are linked to neurological disorders. The main objective of this systematic review and meta‐analysis was to identify any differences in telomere length and the rate of telomere attrition in leukocytes and fibroblasts from people with intellectual disability and controls. Methods: PubMed, Scopus and ScienceDirect were searched. Articles that compared telomere length in individuals with intellectual disability to apparently healthy age‐matched controls were included. Risk of bias was assessed using the AXIS tool and data were analysed using CMA. Results: Fifteen studies comprised of 17 comparisons provided data and were included in meta‐analyses. Compared with healthy controls (N = 481), people with intellectual disability (N = 366) from a known genetic syndrome (Cri du chat, Down, Hoyeraal–Hreidarsson, Williams or Nicolaides–Baraitser) possessed shorter leukocyte telomeres (SMD: −0.853 [95% CI: −1.622 to −0.084], p = 0.03). Similarly, relative to controls (N = 16), people with syndromic intellectual disability (N = 21) possessed shorter fibroblast telomeres (−1.389 [−2.179 to −0.599], p = 0.001). Furthermore, people with syndromic forms of intellectual disability also demonstrated a faster rate (2.09‐fold) of telomere shortening. Conclusions: Consistent with epidemiological findings on mortality and morbidity risk, people with syndromic intellectual disability appear to undergo a faster rate of biological ageing compared to the general population. These findings emphasise the need for healthy ageing lifestyle (i.e., exercise and stress management) and therapeutic interventions for people with syndromic intellectual disability. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=186527212
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/jir.13244
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 641
    Subjects:
      – SubjectFull: DNA analysis
        Type: general
      – SubjectFull: Mortality risk factors
        Type: general
      – SubjectFull: Leukocytes
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Cri-du-chat syndrome
        Type: general
      – SubjectFull: Meta-analysis
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Intellectual disabilities
        Type: general
      – SubjectFull: Systematic reviews
        Type: general
      – SubjectFull: MEDLINE
        Type: general
      – SubjectFull: Chronic diseases
        Type: general
      – SubjectFull: Diseases
        Type: general
      – SubjectFull: Online information services
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Longevity
        Type: general
      – SubjectFull: Active aging
        Type: general
    Titles:
      – TitleFull: Shorter Telomeres and Faster Telomere Attrition in Individuals With Five Syndromic Forms of Intellectual Disability: A Systematic Review and Meta‐Analysis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Hanley, Sarah M.
      – PersonEntity:
          Name:
            NameFull: Schutte, Nicola S.
      – PersonEntity:
          Name:
            NameFull: Bellamy, Jessica
      – PersonEntity:
          Name:
            NameFull: Denham, Joshua
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 09642633
          Numbering:
            – Type: volume
              Value: 69
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Journal of Intellectual Disability Research
              Type: main
ResultId 1