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Scoliosis in spinal muscular atrophy in the era of disease-modifying therapy: a scoping review.

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Title: Scoliosis in spinal muscular atrophy in the era of disease-modifying therapy: a scoping review.
Authors: Gnazzo, Martina (AUTHOR), Pisanò, Giulia (AUTHOR), Piccolo, Benedetta (AUTHOR), Turco, Emanuela Claudia (AUTHOR), Esposito, Susanna (AUTHOR), Pera, Maria Carmela (AUTHOR)
Source: Neurological Sciences. Aug2025, Vol. 46 Issue 8, p3431-3442. 12p.
Subjects: Spinal muscular atrophy, Spine abnormalities, Medical sciences, Scoliosis, Therapeutics
Abstract: Spinal muscular atrophy (SMA) frequently causes scoliosis (up to 90% of cases), due to weakened axial muscles impacting motor and respiratory function. While new SMA treatments improve motor function, their effect on scoliosis progression is unclear. This scoping review (2016-October 2024) analyzed literature from Pubmed, MEDLINE, EMBASE, and Scopus, focusing on studies of SMA, scoliosis, and treatment approaches. The aim of this work was to describe the clinical features and the possible therapeutic approaches of scoliosis in the "new population" of pharmacologically treated SMA patients. We included all types of SMA as well as all the approved disease modifying therapies (DMTs). The review found significant variability in scoliosis presentation and surgical intervention among different types of treated SMA patients. Early pharmacological treatment may slow scoliosis progression, particularly in Type II SMA. Interestingly, Type I SMA patients, who typically don't develop scoliosis due to severe hypotonia, showed an increased scoliosis onset. Larger studies are needed to fully evaluate the impact of different treatments on scoliosis progression in SMA, especially in Type I SMA patients, to establish updated standards of care. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Scoliosis in spinal muscular atrophy in the era of disease-modifying therapy: a scoping review.
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  Data: <searchLink fieldCode="AR" term="%22Gnazzo%2C+Martina%22">Gnazzo, Martina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pisanò%2C+Giulia%22">Pisanò, Giulia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piccolo%2C+Benedetta%22">Piccolo, Benedetta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Turco%2C+Emanuela+Claudia%22">Turco, Emanuela Claudia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Esposito%2C+Susanna%22">Esposito, Susanna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pera%2C+Maria+Carmela%22">Pera, Maria Carmela</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Aug2025, Vol. 46 Issue 8, p3431-3442. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Spinal+muscular+atrophy%22">Spinal muscular atrophy</searchLink><br /><searchLink fieldCode="DE" term="%22Spine+abnormalities%22">Spine abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+sciences%22">Medical sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Scoliosis%22">Scoliosis</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
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  Label: Abstract
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  Data: Spinal muscular atrophy (SMA) frequently causes scoliosis (up to 90% of cases), due to weakened axial muscles impacting motor and respiratory function. While new SMA treatments improve motor function, their effect on scoliosis progression is unclear. This scoping review (2016-October 2024) analyzed literature from Pubmed, MEDLINE, EMBASE, and Scopus, focusing on studies of SMA, scoliosis, and treatment approaches. The aim of this work was to describe the clinical features and the possible therapeutic approaches of scoliosis in the "new population" of pharmacologically treated SMA patients. We included all types of SMA as well as all the approved disease modifying therapies (DMTs). The review found significant variability in scoliosis presentation and surgical intervention among different types of treated SMA patients. Early pharmacological treatment may slow scoliosis progression, particularly in Type II SMA. Interestingly, Type I SMA patients, who typically don't develop scoliosis due to severe hypotonia, showed an increased scoliosis onset. Larger studies are needed to fully evaluate the impact of different treatments on scoliosis progression in SMA, especially in Type I SMA patients, to establish updated standards of care. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=186678226
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        Value: 10.1007/s10072-025-08155-1
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        Text: English
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      – SubjectFull: Medical sciences
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              Text: Aug2025
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              Y: 2025
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