Population preventable fraction of total multiple sclerosis risk associated with non-specific effects of vaccinations against hepatitis B virus and influenza A and B viruses in a middle eastern country.
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| Title: | Population preventable fraction of total multiple sclerosis risk associated with non-specific effects of vaccinations against hepatitis B virus and influenza A and B viruses in a middle eastern country. |
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| Authors: | Akhtar, Saeed (AUTHOR), Muzaini, Hadeel El (AUTHOR), Al-Hashel, Jasem Y. (AUTHOR), Alroughani, Raed (AUTHOR) |
| Source: | Neurological Sciences. Aug2025, Vol. 46 Issue 8, p3775-3782. 8p. |
| Subjects: | Hepatitis B virus, Influenza B virus, Hepatitis B vaccines, Disease risk factors, Vaccination status |
| Abstract: | Background: This study aimed to quantify the population attributable (or prevented) fraction (PAR or PPF) of common risk factors for multiple sclerosis (MS) including family history of MS and vaccine uptake against influenza A and B viruses and hepatitis B virus. Methods: Confirmed MS cases and MS-free controls pair-matched on age (± 5 years), sex and nativity with cases were enrolled. Data were collected through face-to-face interviews both from the cases and controls. An unconditional multivariable logistic regression model was used to analyze the data by including matching factors i.e., age, sex, and nativity as confounders and MS family history and vaccine uptake against influenza viruses and hepatitis B virus as exposures. The adjusted odds ratios and their 95% confidence intervals (CI) were used to compute PAR for family history of MS and PPFs for vaccine uptake against HBV and influenza virus along with their respective 95% CIs. Results: A total of 110 MS cases, and their 110 pair-matched controls were enrolled. The PAF for family history of MS revealed that 22% of MS risk in the population is contributed by family history of MS (PAF = 0.22; 95% CI: 0.10–0.32). The PPFs for vaccination uptake against influenza viruses and/or hepatitis B virus were associated with a significant nonspecific protection against MS risk by 20% (PPF = 0.20; 95% CI: 0.004–0.43) or 30% (PPF = 0.30; 95% CI: 0.03–0.65) respectively. Moreover, the computed joint PPF for vaccination uptake against influenza viruses and hepatitis B virus showed a significantly increased 44% non-specific protection against MS risk (PPF = 0.44; 95% CI: 0.03–0.80). Conclusions: Familial history of MS is associated with 22% population attributable fraction for MS risk, whereas vaccine uptake against influenza viruses or hepatitis B virus conferred a nonspecific protection with population prevented fractions of 20% and 30% respectively suggesting a substantial potential for public health interventions to minimize MS risk in this and other similar settings. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Items | – Name: Title Label: Title Group: Ti Data: Population preventable fraction of total multiple sclerosis risk associated with non-specific effects of vaccinations against hepatitis B virus and influenza A and B viruses in a middle eastern country. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Akhtar%2C+Saeed%22">Akhtar, Saeed</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Muzaini%2C+Hadeel+El%22">Muzaini, Hadeel El</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Al-Hashel%2C+Jasem+Y%2E%22">Al-Hashel, Jasem Y.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alroughani%2C+Raed%22">Alroughani, Raed</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Aug2025, Vol. 46 Issue 8, p3775-3782. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hepatitis+B+virus%22">Hepatitis B virus</searchLink><br /><searchLink fieldCode="DE" term="%22Influenza+B+virus%22">Influenza B virus</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatitis+B+vaccines%22">Hepatitis B vaccines</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Vaccination+status%22">Vaccination status</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: This study aimed to quantify the population attributable (or prevented) fraction (PAR or PPF) of common risk factors for multiple sclerosis (MS) including family history of MS and vaccine uptake against influenza A and B viruses and hepatitis B virus. Methods: Confirmed MS cases and MS-free controls pair-matched on age (± 5 years), sex and nativity with cases were enrolled. Data were collected through face-to-face interviews both from the cases and controls. An unconditional multivariable logistic regression model was used to analyze the data by including matching factors i.e., age, sex, and nativity as confounders and MS family history and vaccine uptake against influenza viruses and hepatitis B virus as exposures. The adjusted odds ratios and their 95% confidence intervals (CI) were used to compute PAR for family history of MS and PPFs for vaccine uptake against HBV and influenza virus along with their respective 95% CIs. Results: A total of 110 MS cases, and their 110 pair-matched controls were enrolled. The PAF for family history of MS revealed that 22% of MS risk in the population is contributed by family history of MS (PAF = 0.22; 95% CI: 0.10–0.32). The PPFs for vaccination uptake against influenza viruses and/or hepatitis B virus were associated with a significant nonspecific protection against MS risk by 20% (PPF = 0.20; 95% CI: 0.004–0.43) or 30% (PPF = 0.30; 95% CI: 0.03–0.65) respectively. Moreover, the computed joint PPF for vaccination uptake against influenza viruses and hepatitis B virus showed a significantly increased 44% non-specific protection against MS risk (PPF = 0.44; 95% CI: 0.03–0.80). Conclusions: Familial history of MS is associated with 22% population attributable fraction for MS risk, whereas vaccine uptake against influenza viruses or hepatitis B virus conferred a nonspecific protection with population prevented fractions of 20% and 30% respectively suggesting a substantial potential for public health interventions to minimize MS risk in this and other similar settings. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-025-08187-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 3775 Subjects: – SubjectFull: Hepatitis B virus Type: general – SubjectFull: Influenza B virus Type: general – SubjectFull: Hepatitis B vaccines Type: general – SubjectFull: Disease risk factors Type: general – SubjectFull: Vaccination status Type: general Titles: – TitleFull: Population preventable fraction of total multiple sclerosis risk associated with non-specific effects of vaccinations against hepatitis B virus and influenza A and B viruses in a middle eastern country. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Akhtar, Saeed – PersonEntity: Name: NameFull: Muzaini, Hadeel El – PersonEntity: Name: NameFull: Al-Hashel, Jasem Y. – PersonEntity: Name: NameFull: Alroughani, Raed IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 46 – Type: issue Value: 8 Titles: – TitleFull: Neurological Sciences Type: main |
| ResultId | 1 |
